Search Results - "Dain, J G"

Biotransformation of Clozapine in Humans by DAIN, J. G, NICOLETTI, J, BALLARD, F

“…The metabolic pathways of clozapine (CZ, Clozaril (Novartis Pharmaceuticals Corporation, East Hanover, NJ),…”
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Biotransformation of fluvastatin sodium in humans by Dain, J G, Fu, E, Gorski, J, Nicoletti, J, Scallen, T J

“…The metabolic pathways of fluvastatin sodium (FV; Lescol, Sandoz compound XU 62-320), [R*,S*-(E)]-(+-)-sodium-3,5-dihydroxy-7-[3-…”
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Reduction in Glucose Levels in STZ Diabetic Rats by 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid:  A Prodrug Approach for Targeting the Liver by Bebernitz, Gregory R, Dain, Jeremy G, Deems, Rhonda O, Otero, Dario A, Simpson, W. Ronald, Strohschein, Robert J

“…The overproduction of glucose by the liver in NIDDM patients markedly contributes to their fasting hyperglycemia and is a direct consequence of the increased…”
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Hypoglycemic Prodrugs of 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid by Aicher, Thomas D, Bebernitz, Gregory R, Bell, Philip A, Brand, Leonard J, Dain, Jeremy G, Deems, Rhonda, Fillers, William S, Foley, James E, Knorr, Douglas C, Nadelson, Jeffrey, Otero, Dario A, Simpson, Ronald, Strohschein, Robert J, Young, Douglas A

“…SAH 51-641 (1) is a potent hypoglycemic agent, which acts by inhibiting hepatic gluconeogenesis. It is a prodrug of 4-(2,2-dimethyl-1-oxopropyl)benzoic acid…”
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Metabolic pathways of 4-[(3-methoxyphenyl)methyl]-2,2,6,6-tetramethyl-1-oxa-4-aza-2,6- disilacyclohexane (MPSC) hydrochloride, a silicon-containing xenobiotic, in rat, dog, and man by Dain, J G, Nicoletti, J

“…1. The metabolic pathways of Sandoz compound 58-112, 4-[(3-methyoxyphenyl)-methyl]-2,2,6,6-tetramethyl-1-oxa-4-aza-2,6- disilacyclohexane (MPSC) hydrochloride…”
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Effect of diet and gavage on the absorption and metabolism of fluperlapine in the rat by Dain, J G, Jaffe, J M

“…Fluperlapine, Sandoz compound NB 106-689, 3-fluoro-6-(4-methyl-1-piperazinyl)-11H-dibenz[b,e]azepine, in a 12-week toxicity study exhibited liver toxicity…”
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A regulatory and industrial perspective of the use of carbon-14 and tritium isotopes in human ADME studies by DAIN, J. G, COLLINS, J. M, ROBINSON, W. T

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Metabolism of butalbital, 5-allyl-5-isobutylbarbituric acid, in the dog by Dain, J G, Bhuta, S I, Coombs, R A, Talbot, K C, Dugger, H A

“…Butalbital, 5-allyl-5-isobutylbarbituric acid, labeled in the 2-position with 14C, was administered to dogs. Ninety-two percent of the radioactivity of the…”
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Disposition of [3H]fluvastatin following single oral doses in beagle dogs and rhesus monkeys with bile fistulae by Tse, F L, Dain, J G, Kalafsky, G

“…The disposition of [3H]fluvastatin was examined following single oral doses in dogs (12.4 mg kg-1) and monkeys (0.48 and 45.5 mg kg-1) with bile fistulae…”
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The formation of 6-ethylsalicylic acid by Mycobacterium phlei by Dain, J G, Ernst, L A, Campbell, I M, Bentley, R

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Thomas Albert Longmore; 1905-1957 by DAIN, J G

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Pharmacokinetics and metabolism of alpha-[(dimethylamino)methyl]-2- (3-ethyl-5-methyl-4-isoxazolyl)-1H-indole-3-methanol, a hypoglycemic agent, in man by Tse, F L, Orwig, B A, Jaffe, J M, Dain, J G

“…1. The pharmacokinetics and metabolism of alpha-[(dimethylamino)methyl]-2-(3-ethyl-5-methyl-4-isoxazolyl) -1H-[3-14C]indole-3-methanol, a new hypoglycemic…”
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Pharmacokinetics of compound 58-112, a potential skeletal muscle relaxant, in man by Tse, F L, Jaffe, J M, Dain, J G

“…The pharmacokinetics of 4-[(3-methoxyphenyl)methyl] -2,2,6,6-tetramethyl-1-oxa-4-aza-2,6-disilacyclohexane (Sandoz compound 58-112), a new chemical entity with…”
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Reduction in Glucose Levels in STZ Diabetic Rats by 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid:  A Prodrug Approach for Targeting the Liver by Bebernitz, Gregory R, Dain, Jeremy G, Deems, Rhonda O, Otero, Dario A, Simpson, W. Ronald, Strohschein, Robert J

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s-Triazolone ring system as a new cis-azo dienophile by Gillis, Bernard T, Dain, Jeremy G

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