Search Results - "Dailey, Lisa"

Air pollutants disrupt iron homeostasis to impact oxidant generation, biological effects, and tissue injury by Ghio, Andrew J., Soukup, Joleen M., Dailey, Lisa A., Madden, Michael C.

“…Air pollutants cause changes in iron homeostasis through: 1) a capacity of the pollutant, or a metabolite(s), to complex/chelate iron from pivotal sites in the…”
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Mucus increases cell iron uptake to impact the release of pro-inflammatory mediators after particle exposure by Ghio, Andrew J., Soukup, Joleen M., Dailey, Lisa A., Roggli, Victor L.

“…We tested the hypothesis that (1) mucus production can be included in the cell response to iron deficiency; (2) mucus binds iron and increases cell metal…”
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Distinct microRNA expression in human airway cells of asthmatic donors identifies a novel asthma-associated gene by Jardim, Melanie J, Dailey, Lisa, Silbajoris, Robert, Diaz-Sanchez, David

“…Airway inflammation is a hallmark of asthma, and suggests a dysregulation of homeostatic mechanisms. MicroRNAs (miRNAs) are key regulators of gene expression…”
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Differential expression of pro-inflammatory and oxidative stress mediators induced by nitrogen dioxide and ozone in primary human bronchial epithelial cells by Mirowsky, Jaime E., Dailey, Lisa A., Devlin, Robert B.

“…Context: NO 2 and O 3 are ubiquitous air toxicants capable of inducing lung damage to the respiratory epithelium. Due to their oxidizing capabilities, these…”
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Mechanisms underlying differential responses to FGF signaling by Dailey, Lisa, Ambrosetti, Davide, Mansukhani, Alka, Basilico, Claudio

“…Fibroblast growth factors (FGFs) are key regulators of several developmental processes in which cell fate and differentiation to various tissue lineages are…”
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Transcriptional Profiling of Mucociliary Differentiation in Human Airway Epithelial Cells by Ross, Andrea J, Dailey, Lisa A, Brighton, Luisa E, Devlin, Robert B

“…When cultured at an air-liquid interface (ALI) in the appropriate medium, primary human airway epithelial cells form a polarized, pseudostratified epithelium…”
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Associations between ambient air pollution and blood markers of inflammation and coagulation/fibrinolysis in susceptible populations by Rückerl, Regina, Hampel, Regina, Breitner, Susanne, Cyrys, Josef, Kraus, Ute, Carter, Jackie, Dailey, Lisa, Devlin, Robert B., Diaz-Sanchez, David, Koenig, Wolfgang, Phipps, Richard, Silbajoris, Robert, Soentgen, Jens, Soukup, Joleen, Peters, Annette, Schneider, Alexandra

“…The pathophysiological pathways linking particulate air pollution to cardiovascular disease are still not fully understood. We examined the association between…”
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Air pollution particles and iron homeostasis by Ghio, Andrew J., Soukup, Joleen M., Dailey, Lisa A.

“…The mechanism underlying biological effects, including pro-inflammatory outcomes, of particles deposited in the lung has not been defined. A disruption in iron…”
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Ozone Responsive Gene Expression as a Model for Describing Repeat Exposure Response Trajectories and Interindividual Toxicodynamic Variability In Vitro by Bowers, Emma C, Martin, Elizabeth M, Jarabek, Annie M, Morgan, David S, Smith, Hannah J, Dailey, Lisa A, Aungst, Emily R, Diaz-Sanchez, David, McCullough, Shaun D

“…Abstract Inhaled chemical/material exposures are a ubiquitous part of daily life around the world. There is a need to evaluate potential adverse effects of…”
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Exposure to wood smoke particles produces inflammation in healthy volunteers by Ghio, Andrew J, Soukup, Joleen M, Case, Martin, Dailey, Lisa A, Richards, Judy, Berntsen, Jon, Devlin, Robert B, Stone, Susan, Rappold, Ana

“…ObjectivesHuman exposure to wood smoke particles (WSP) impacts on human health through changes in indoor air quality, exposures from wild fires, burning of…”
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FIREWACh: high-throughput functional detection of transcriptional regulatory modules in mammalian cells by Murtha, Matthew, Tokcaer-Keskin, Zeynep, Tang, Zuojian, Strino, Francesco, Chen, Xi, Wang, Yatong, Xi, Xiangmei, Basilico, Claudio, Brown, Stuart, Bonneau, Richard, Kluger, Yuval, Dailey, Lisa

“…Screening of cells transduced with a lentivirus library harboring nucleosome-free regions of mammalian genomes identifies cis elements that regulate…”
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Growth of human bronchial epithelial cells at an air-liquid interface alters the response to particle exposure by Ghio, Andrew J, Dailey, Lisa A, Soukup, Joleen M, Stonehuerner, Jacqueline, Richards, Judy H, Devlin, Robert B

“…We tested the hypothesis that normal human bronchial epithelial (NHBE) cells 1) grown submerged in media and 2) allowed to differentiate at air-liquid…”
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Particulate Matter in Cigarette Smoke Alters Iron Homeostasis to Produce a Biological Effect by Ghio, Andrew J, Hilborn, Elizabeth D, Stonehuerner, Jacqueline G, Dailey, Lisa A, Carter, Jacqueline D, Richards, Judy H, Crissman, Kay M, Foronjy, Robert F, Uyeminami, Dale L, Pinkerton, Kent E

“…Lung injury after cigarette smoking is related to particle retention. Iron accumulates with the deposition of these particles. We tested the postulate that (1)…”
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ERK1/2 and p38 regulate inter-individual variability in ozone-mediated IL-8 gene expression in primary human bronchial epithelial cells by Bowers, Emma C., McCullough, Shaun D., Morgan, David S., Dailey, Lisa A., Diaz-Sanchez, David

“…Inter-individual variability is observed in all biological responses; however this variability is difficult to model and its underlying mechanisms are often…”
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Benchmark Dose Modeling Approaches for Volatile Organic Chemicals Using a Novel Air-Liquid Interface In Vitro Exposure System by Speen, Adam M, Murray, Jessica R, Krantz, Quentin Todd, Davies, David, Evansky, Paul, Harrill, Joshua A, Everett, Logan J, Bundy, Joseph L, Dailey, Lisa A, Hill, Jazzlyn, Zander, Wyatt, Carlsten, Elise, Monsees, Michael, Zavala, Jose, Higuchi, Mark A

“…Abstract Inhalation is the most relevant route of volatile organic chemical (VOC) exposure; however, due to unique challenges posed by their chemical…”
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Diacetyl exposure disrupts iron homeostasis in animals and cells by Ghio, Andrew J., Soukup, Joleen M., Dailey, Lisa A., Roggli, Victor L., Crumbliss, Alvin L., Palmer, Scott M.

“…Several mechanisms have been proposed for the biological effect of diacetyl. We tested the postulate that animal and cell exposures to diacetyl are associated…”
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Ozone Reacts With Carbon Black to Produce a Fulvic Acid-Like Substance and Increase an Inflammatory Effect by Ghio, Andrew J., Gonzalez, David H., Paulson, Suzanne E., Soukup, Joleen M., Dailey, Lisa A., Madden, Michael C., Mahler, Beth, Elmore, Susan A., Schladweiler, Mette C., Kodavanti, Urmila P.

“…Exposure to ambient ozone has been associated with increased human mortality. Ozone exposure can introduce oxygen-containing functional groups in particulate…”
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Monitoring redox stress in human airway epithelial cells exposed to woodsmoke at an air-liquid interface by Abzhanova, Aiman, Berntsen, Jon, Pennington, Edward R, Dailey, Lisa, Masood, Syed, George, Ingrid, Warren, Nina, Martin, Joseph, Hays, Michael D, Ghio, Andrew J, Weinstein, Jason P, Kim, Yong Ho, Puckett, Earl, Samet, James M

“…Wildland fires contribute significantly to the ambient air pollution burden worldwide, causing a range of adverse health effects in exposed populations. The…”
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Liquid application dosing alters the physiology of air-liquid interface (ALI) primary human bronchial epithelial cell/lung fibroblast co-cultures and in vitro testing relevant endpoints by Mallek, Nicholas M, Martin, Elizabeth M, Dailey, Lisa A, McCullough, Shaun D

“…Differentiated primary human bronchial epithelial cell (dpHBEC) cultures grown under air-liquid interface (ALI) conditions exhibit key features of the human…”
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Ozone induces a proinflammatory response in primary human bronchial epithelial cells through mitogen-activated protein kinase activation without nuclear factor-κB activation by McCullough, Shaun D, Duncan, Kelly E, Swanton, Samantha M, Dailey, Lisa A, Diaz-Sanchez, David, Devlin, Robert B

“…Ground-level ozone (O3) is a ubiquitous environmental air pollutant that is a potent inducer of airway inflammation and has been linked with respiratory and…”
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