Search Results - "Daigo, Yataro"

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases by Ishigaki, Kazuyoshi, Akiyama, Masato, Kanai, Masahiro, Takahashi, Atsushi, Kawakami, Eiryo, Sugishita, Hiroki, Sakaue, Saori, Matoba, Nana, Low, Siew-Kee, Okada, Yukinori, Terao, Chikashi, Amariuta, Tiffany, Gazal, Steven, Kochi, Yuta, Horikoshi, Momoko, Suzuki, Ken, Ito, Kaoru, Koyama, Satoshi, Ozaki, Kouichi, Niida, Shumpei, Sakata, Yasushi, Sakata, Yasuhiko, Kohno, Takashi, Shiraishi, Kouya, Momozawa, Yukihide, Hirata, Makoto, Matsuda, Koichi, Ikeda, Masashi, Iwata, Nakao, Ikegawa, Shiro, Kou, Ikuyo, Tanaka, Toshihiro, Nakagawa, Hidewaki, Suzuki, Akari, Hirota, Tomomitsu, Tamari, Mayumi, Chayama, Kazuaki, Miki, Daiki, Mori, Masaki, Nagayama, Satoshi, Daigo, Yataro, Miki, Yoshio, Katagiri, Toyomasa, Ogawa, Osamu, Obara, Wataru, Ito, Hidemi, Yoshida, Teruhiko, Imoto, Issei, Takahashi, Takashi, Tanikawa, Chizu, Suzuki, Takao, Sinozaki, Nobuaki, Minami, Shiro, Yamaguchi, Hiroki, Asai, Satoshi, Takahashi, Yasuo, Yamaji, Ken, Takahashi, Kazuhisa, Fujioka, Tomoaki, Takata, Ryo, Yanai, Hideki, Masumoto, Akihide, Koretsune, Yukihiro, Kutsumi, Hiromu, Higashiyama, Masahiko, Murayama, Shigeo, Minegishi, Naoko, Suzuki, Kichiya, Tanno, Kozo, Shimizu, Atsushi, Yamaji, Taiki, Iwasaki, Motoki, Sawada, Norie, Uemura, Hirokazu, Tanaka, Keitaro, Naito, Mariko, Sasaki, Makoto, Wakai, Kenji, Tsugane, Shoichiro, Yamamoto, Masayuki, Yamamoto, Kazuhiko, Murakami, Yoshinori, Nakamura, Yusuke, Raychaudhuri, Soumya, Inazawa, Johji, Yamauchi, Toshimasa, Kadowaki, Takashi, Kubo, Michiaki, Kamatani, Yoichiro

“…The overwhelming majority of participants in current genetic studies are of European ancestry. To elucidate disease biology in the East Asian population, we…”
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RAS-Mitogen-Activated Protein Kinase Signal Is Required for Enhanced PD-L1 Expression in Human Lung Cancers by Sumimoto, Hidetoshi, Takano, Atsushi, Teramoto, Koji, Daigo, Yataro

“…Ectopic programmed cell death ligand 1 (PD-L1) expression in non-small cell lung cancers (NSCLCs) is related to immune evasion by cancer, and it is a molecular…”
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Clinical significance of PD-L1-positive cancer-associated fibroblasts in pN0M0 non-small cell lung cancer by Teramoto, Koji, Igarashi, Tomoyuki, Kataoka, Yoko, Ishida, Mitsuaki, Hanaoka, Jun, Sumimoto, Hidetoshi, Daigo, Yataro

“…•Cancer-associated fibroblasts (CAFs) play critical pro-tumorigenic roles in tumor stroma.•PD-L1 expression on CAFs is reversibly regulated by IFN-γ released…”
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High co-expression of IL-34 and M-CSF correlates with tumor progression and poor survival in lung cancers by Baghdadi, Muhammad, Endo, Hiraku, Takano, Atsushi, Ishikawa, Kozo, Kameda, Yosuke, Wada, Haruka, Miyagi, Yohei, Yokose, Tomoyuki, Ito, Hiroyuki, Nakayama, Haruhiko, Daigo, Yataro, Suzuki, Nao, Seino, Ken-ichiro

“…Despite recent advances in diagnosis and treatment of lung cancers, the 5-year survival rate remains unsatisfactory, which necessitates the identification of…”
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Genome-wide association study of hematological and biochemical traits in a Japanese population by Nakamura, Yusuke, Matsuda, Koichi, Daigo, Yataro, Kamatani, Yoichiro, Okada, Yukinori, Kamatani, Naoyuki, Kubo, Michiaki, Hosono, Naoya

“…Naoyuki Kamatani and colleagues report genome-wide association studies for 8 hematological traits and 12 biochemical traits in a Japanese population. We report…”
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Cancer‐associated fibroblast‐targeted strategy enhances antitumor immune responses in dendritic cell‐based vaccine by Ohshio, Yasuhiko, Teramoto, Koji, Hanaoka, Jun, Tezuka, Noriaki, Itoh, Yasushi, Asai, Tohru, Daigo, Yataro, Ogasawara, Kazumasa

“…Given the close interaction between tumor cells and stromal cells in the tumor microenvironment (TME), TME‐targeted strategies would be promising for…”
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Glutamine deficiency drives transforming growth factor‐β signaling activation that gives rise to myofibroblastic carcinoma‐associated fibroblasts by Mezawa, Yoshihiro, Wang, Tingwei, Daigo, Yataro, Takano, Atsushi, Miyagi, Yohei, Yokose, Tomoyuki, Yamashita, Toshinari, Yang, Liying, Maruyama, Reo, Seimiya, Hiroyuki, Orimo, Akira

“…Abstract Tumor‐promoting carcinoma‐associated fibroblasts (CAFs), abundant in the mammary tumor microenvironment (TME), maintain transforming growth factor‐β…”
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Association of a novel long non‐coding RNA in 8q24 with prostate cancer susceptibility by Chung, Suyoun, Nakagawa, Hidewaki, Uemura, Motohide, Piao, Lianhua, Ashikawa, Kyota, Hosono, Naoya, Takata, Ryo, Akamatsu, Shusuke, Kawaguchi, Takahisa, Morizono, Takashi, Tsunoda, Tatsuhiko, Daigo, Yataro, Matsuda, Koichi, Kamatani, Naoyuki, Nakamura, Yusuke, Kubo, Michiaki

“…Recent genome‐wide association studies reported strong and reproducible associations of multiple genetic variants in a large “gene‐desert” region of chromosome…”
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Overexpression of CDC20 predicts poor prognosis in primary non-small cell lung cancer patients by Kato, Tatsuya, Daigo, Yataro, Aragaki, Masato, Ishikawa, Keidai, Sato, Masaaki, Kaji, Mitsuhito

“…Background This study examined the expression of CDC20 in human non‐small cell lung cancer (NSCLC), explored its clinicopathological significance, and…”
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Holliday junction recognition protein as a prognostic biomarker and therapeutic target for oral cancer by Tsevegjav, Bayarbat, Takano, Atsushi, Zhu, Ming, Yoshitake, Yoshihiro, Shinohara, Masanori, Daigo, Yataro

“…Since oral cancer (OC) is highly malignant and the efficacy of standard treatments is limited, the development of new therapeutics is urgently awaited. To…”
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Biphasic prognostic significance of PD-L1 expression status in patients with early- and locally advanced-stage non-small cell lung cancer by Teramoto, Koji, Igarashi, Tomoyuki, Kataoka, Yoko, Ishida, Mitsuaki, Hanaoka, Jun, Sumimoto, Hidetoshi, Daigo, Yataro

“…Programmed cell death-ligand 1 (PD-L1) expression on tumor cells is induced by interferon-gamma, suggesting the induction of an anti-tumor immune response. In…”
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Characterization of Opa interacting protein 5 as a new biomarker and therapeutic target for oral cancer by Zhu, Ming, Takano, Atsushi, Tsevegjav, Bayarbat, Yoshitake, Yoshihiro, Shinohara, Masanori, Daigo, Yataro

“…Oral cancer is a leading cause of cancer-related death worldwide. Current treatment for oral cancer includes surgery, radiotherapy, and chemotherapy; however,…”
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Identification of human leukocyte antigen‐A24‐restricted epitope peptides derived from gene products upregulated in lung and esophageal cancers as novel targets for immunotherapy by Suda, Takako, Tsunoda, Takuya, Daigo, Yataro, Nakamura, Yusuke, Tahara, Hideaki

“…For the development of cancer vaccine therapies, we have searched for possible epitope peptides that can elicit cytotoxic T lymphocytes (CTL) to the TTK…”
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Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker by Takawa, Masashi, Masuda, Ken, Kunizaki, Masaki, Daigo, Yataro, Takagi, Katsunori, Iwai, Yukiko, Cho, Hyun‐Soo, Toyokawa, Gouji, Yamane, Yuka, Maejima, Kazuhiro, Field, Helen I., Kobayashi, Takaaki, Akasu, Takayuki, Sugiyama, Masanori, Tsuchiya, Eijyu, Atomi, Yutaka, Ponder, Bruce A. J., Nakamura, Yusuke, Hamamoto, Ryuji

“…The emphasis in anticancer drug discovery has always been on finding a drug with great antitumor potential but few side‐effects. This can be achieved if the…”
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Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume by Uchimura, Yasuhiro, Hino, Kodai, Hattori, Kosuke, Kubo, Yoshinori, Owada, Airi, Kimura, Tomoko, Sugawara, Lucia, Kume, Shinji, Bellier, Jean-Pierre, Yanagisawa, Daijiro, Shiino, Akihiko, Nakayama, Takahisa, Daigo, Yataro, Mashimo, Tomoji, Udagawa, Jun

“…Epidemiological studies suggest that poor nutrition during pregnancy predisposes offspring to the development of lifestyle-related noncommunicable diseases and…”
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Regulation of histone modification and chromatin structure by the p53–PADI4 pathway by Tanikawa, Chizu, Espinosa, Martha, Suzuki, Akari, Masuda, Ken, Yamamoto, Kazuhiko, Tsuchiya, Eiju, Ueda, Koji, Daigo, Yataro, Nakamura, Yusuke, Matsuda, Koichi

“…Histone proteins are modified in response to various external signals; however, their mechanisms are still not fully understood. Citrullination is a…”
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Pre-existing autoimmune disease as a risk factor for immune-related adverse events in cancer patients receiving immune checkpoint inhibitors by Sumimoto, Hidetoshi, Noda, Satoshi, Koide, Hiroyoshi, Douke, Yutaro, Sakai, Kosuke, Nishikawa, Akihito, Tomioka, Azumi, Hori, Maki, Nakato, Hiromi, Kimura, Yuri, Tokuda, Aya, Takano, Atsushi, Teramoto, Koji, Murata, Satoshi, Daigo, Yataro

“…Immune checkpoint inhibitors (ICIs) have been widely used as standard therapies for various cancers. However, in 20-30% of cases, ICIs can lead to…”
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Characterization of KIF20A as a prognostic biomarker and therapeutic target for different subtypes of breast cancer by Nakamura, Masako, Takano, Atsushi, Thang, Phung Manh, Tsevegjav, Bayarbat, Zhu, Ming, Yokose, Tomoyuki, Yamashita, Toshinari, Miyagi, Yohei, Daigo, Yataro

“…The aim of the present study was to identify novel prognostic biomarkers and therapeutic targets for breast cancer; thus, genes that are frequently…”
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A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population by Shiraishi, Kouya, Kunitoh, Hideo, Daigo, Yataro, Takahashi, Atsushi, Goto, Koichi, Sakamoto, Hiromi, Ohnami, Sumiko, Shimada, Yoko, Ashikawa, Kyota, Saito, Akira, Watanabe, Shun-ichi, Tsuta, Koji, Kamatani, Naoyuki, Yoshida, Teruhiko, Nakamura, Yusuke, Yokota, Jun, Kubo, Michiaki, Kohno, Takashi

“…Takashi Kohno and colleagues identify two new susceptibility loci for lung adenocarcinoma in the Japanese population. They also replicate previously identified…”
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Phosphorylation of hTERT at threonine 249 is a novel tumor biomarker of aggressive cancer with poor prognosis in multiple organs by Matsuda, Yoko, Yamashita, Taro, Ye, Juanjuan, Yasukawa, Mami, Yamakawa, Keiko, Mukai, Yuri, Machitani, Mitsuhiro, Daigo, Yataro, Miyagi, Yohei, Yokose, Tomoyuki, Oshima, Takashi, Ito, Hiroyuki, Morinaga, Soichiro, Kishida, Takeshi, Minamoto, Toshinari, Yamada, Shinji, Takei, Junko, Kaneko, Mika K, Kojima, Motohiro, Kaneko, Shuichi, Masaki, Tsutomu, Hirata, Masahiro, Haba, Reiji, Kontani, Keiichi, Kanaji, Nobuhiro, Miyatake, Nobuyuki, Okano, Keiichi, Kato, Yukinari, Masutomi, Kenkichi

“…Recent evidence indicates that RNA‐dependent RNA polymerase (RdRP) activity of human telomerase reverse transcriptase (hTERT) regulates expression of target…”
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