Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study

Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study

Background Atopic dermatitis is characterized by impaired skin barrier and altered cutaneous innate immunity. The estimated prevalence among Egyptian children was 10–12%. Several studies suggest that it may be associated with systemic comorbidities other than the spectrum of atopy, such as metabolic...

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Bibliographic Details
Published in:The Gazette of the Egyptian Paediatric Association Vol. 69; no. 1; pp. 1 - 5
Main Authors: Mohamed, Amal Ahmed, Salah, Eman Mohamed, Bedair, Nermeen Ibrahim, Bassiouny, Dina M., Daifalla, Aliaa E. M., Behairy, Ola G., Fawazy, Naglaa, Al Soda, Mohamed F., Farag, Youssef M. K.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 03-11-2021
Springer Nature B.V
SpringerOpen
Subjects:
Age
Atopic dermatitis
Biomarkers
Body mass index
C reactive protein
Cholesterol
Dermatitis
Diabetes
Dyslipidemia
Eczema
Fasting
Glucose
Glutamyl gamma transferase
Hypotheses
IgE
Insulin
Laboratories
Medicine
Medicine & Public Health
Metabolic disorders
Pediatrics
Phosphatase
Skin
Triglycerides
Alkaline phosphatase
Atopic dermatitis
IgE
Dyslipidemia
Glutamyl gamma transferase
Diabetes
C reactive protein
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Summary:Background Atopic dermatitis is characterized by impaired skin barrier and altered cutaneous innate immunity. The estimated prevalence among Egyptian children was 10–12%. Several studies suggest that it may be associated with systemic comorbidities other than the spectrum of atopy, such as metabolic syndrome and other inflammatory conditions. The aim of this study is to compare the profile of systemic conditions of diabetes, dyslipidemia, and multiple inflammatory markers in children with and without diagnosed atopic dermatitis. Methods One hundred atopic dermatitis patients and 101 normal controls were collected from outpatient clinic based on their clinical condition, both had measurement of body mass index, blood sugar, serum insulin, lipid profile, C reactive protein, and gamma-glutamyl transferase. Results Children diagnosed with atopic dermatitis had significantly higher levels of body mass index (34.7 ± 5.7 vs 26.1 ± 4.9), fasting glucose (143.2 ± 30.3 vs 100.8 ± 16.0), serum insulin (11.3 ± 4.4 vs. 4.6 ± 3.0), serum triglycerides (194.1 ± 38.1 vs 156.2 ± 31.6), total cholesterol (198.4 ± 27.7 vs 163.7 ± 27.7), alkaline phosphatase (229.4 ± 89.8 vs. 189.4 ± 46.8), and gamma-glutamyl transferase (54.7 ± 19.9 vs 34.3 ± 9.5), C-reactive protein level was approximately four times higher (19.9 ± 13.2 vs 5.1 ± 3.4) and the immunoglobulin E level was approximately 10 times higher (2050.3 ± 843.8 vs 252.7 ± 103.1) than in controls Conclusion We found a positive relationship of atopic dermatitis with both diabetes and hyperlipidemia among children, and positive dose-response relationship of several non-traditional biomarkers of C-reactive protein, gamma-glutamyl transferase, and alkaline phosphatase with the presence and severity of atopic dermatitis.
ISSN:2090-9942
1110-6638
2090-9942
DOI:10.1186/s43054-021-00083-x