Search Results - "Dai, Xinghong"
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Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes
Published in Science (American Association for the Advancement of Science) (06-04-2018)“…Herpes simplex viruses (HSVs) rely on capsid-associated tegument complex (CATC) for long-range axonal transport of their genome-containing capsids between…”
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In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus
Published in Nature (London) (05-01-2017)“…A high-resolution structure of the bacteriophage MS2 sheds light on the structure of the genome and how the genome is delivered into a bacterium. Atomic…”
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Utilizing AI and IoT technologies for identifying risk factors in sports
Published in Heliyon (15-06-2024)“…A dynamic cooperation is poised to redefine the limits of athlete safety and performance optimization in the dynamic field of sports science. A new age in…”
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Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection
Published in Cell reports (Cambridge) (10-10-2017)“…The human cerebral cortex possesses distinct structural and functional features that are not found in the lower species traditionally used to model brain…”
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25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model
Published in Immunity (Cambridge, Mass.) (21-03-2017)“…Zika virus (ZIKV) has become a public health threat due to its global transmission and link to severe congenital disorders. The host immune responses to ZIKV…”
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A yellow fever virus NS4B inhibitor not only suppresses viral replication, but also enhances the virus activation of RIG-I-like receptor-mediated innate immune response
Published in PLoS pathogens (01-01-2022)“…Flavivirus infection of cells induces massive rearrangements of the endoplasmic reticulum (ER) membrane to form viral replication organelles (ROs) which…”
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High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike
Published in Nature communications (10-04-2023)“…Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-19 vaccines. All COVID-19 vaccines in the US encode spike with…”
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Efficient long-term amplification of hepatitis B virus isolates after infection of slow proliferating HepG2-NTCP cells
Published in Journal of hepatology (01-08-2019)“…[Display omitted] •Cell culture system that mimicks complete HBV life cycle from entry to egress.•Efficient in vitro infection with crude HBV patient sera.•Up…”
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Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex
Published in Biochemistry (Easton) (24-04-2018)“…Pyruvate dehydrogenase complex (PDC) is a large multienzyme complex that catalyzes the irreversible conversion of pyruvate to acetyl-coenzyme A with reduction…”
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Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie bandavirus in aged ferrets
Published in mBio (01-10-2023)“…(DBV) is an emerging tick-borne virus that causes severe fever with thrombocytopenia syndrome (SFTS) in infected patients. Human SFTS symptoms progress from…”
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Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development
Published in PLoS pathogens (01-02-2019)“…Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more…”
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CryoEM and mutagenesis reveal that the smallest capsid protein cements and stabilizes Kaposi's sarcoma-associated herpesvirus capsid
Published in Proceedings of the National Academy of Sciences - PNAS (17-02-2015)“…With just one eighth the size of the major capsid protein (MCP), the smallest capsid protein (SCP) of human tumor herpesviruses—Kaposi's sarcoma-associated…”
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Effects of Additives and Planting Density on Silage Performance and Bacterial Community of Novel Sorghum bicolor × S. propinquum Hybrids
Published in Fermentation (Basel) (01-08-2024)“…In the enhancement of Novel Sorghum bicolor × S. propinquum Hybrid utilization, optimal planting densities and silage methods remain elusive. This study…”
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Regional differences of physical fitness and overweight and obesity prevalence among college students before and after COVID-19 pandemic since the "double first-class" initiative in China
Published in Frontiers in public health (2023)“…Physical fitness has been widely recognized as a powerful marker of health in children and adolescents, and it negatively affected by the COVID-19 pandemic…”
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The smallest capsid protein mediates binding of the essential tegument protein pp150 to stabilize DNA-containing capsids in human cytomegalovirus
Published in PLoS pathogens (01-08-2013)“…Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that causes birth defects in newborns and life-threatening complications in immunocompromised…”
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Structures of capsid and capsid-associated tegument complex inside the Epstein–Barr virus
Published in Nature microbiology (01-10-2020)“…As the first discovered human cancer virus, Epstein–Barr virus (EBV) causes Burkitt’s lymphoma and nasopharyngeal carcinoma. Isolating virions for determining…”
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Cryo-EM Structure of a Molluscan Hemocyanin Suggests Its Allosteric Mechanism
Published in Structure (London) (02-04-2013)“…Hemocyanins are responsible for transporting O2 in the arthropod and molluscan hemolymph. Haliotis diversicolor molluscan hemocyanin isoform 1 (HdH1) is an 8…”
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Purification of Herpesvirus Virions and Capsids
Published in Bio-protocol (05-08-2014)“…This protocol was designed for large-scale purification of herpesvirus particles by cell culture. Virions and capsids are isolated from extracellular culture…”
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Artificial Intelligence Analysis of Outdoor Sports Risk Self-Assessment on Insurance Psychology
Published in International journal of environmental research and public health (10-02-2023)“…The development potential of China's medical insurance market is huge, and the research on medical insurance demand has always been the focus of academic…”
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Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome
Published in Nature (London) (01-06-2019)“…Herpesviruses are enveloped viruses that are prevalent in the human population and are responsible for diverse pathologies, including cold sores, birth defects…”
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