Search Results - "Dai, Xiao‐Qing"

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes by Camunas-Soler, Joan, Dai, Xiao-Qing, Hang, Yan, Bautista, Austin, Lyon, James, Suzuki, Kunimasa, Kim, Seung K., Quake, Stephen R., MacDonald, Patrick E.

“…Impaired function of pancreatic islet cells is a major cause of metabolic dysregulation and disease in humans. Despite this, it remains challenging to directly…”
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Cryopreservation and post-thaw characterization of dissociated human islet cells by Marquez-Curtis, Leah A, Dai, Xiao-Qing, Hang, Yan, Lam, Jonathan Y, Lyon, James, Manning Fox, Jocelyn E, McGann, Locksley E, MacDonald, Patrick E, Kim, Seung K, Elliott, Janet A W

“…The objective of this study is to optimize the cryopreservation of dissociated islet cells and obtain functional cells that can be used in single-cell…”
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Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance by Skovsø, Søs, Panzhinskiy, Evgeniy, Kolic, Jelena, Cen, Haoning Howard, Dionne, Derek A., Dai, Xiao-Qing, Sharma, Rohit B., Elghazi, Lynda, Ellis, Cara E., Faulkner, Katharine, Marcil, Stephanie A. M., Overby, Peter, Noursadeghi, Nilou, Hutchinson, Daria, Hu, Xiaoke, Li, Hong, Modi, Honey, Wildi, Jennifer S., Botezelli, J. Diego, Noh, Hye Lim, Suk, Sujin, Gablaski, Brian, Bautista, Austin, Kim, Ryekjang, Cras-Méneur, Corentin, Flibotte, Stephane, Sinha, Sunita, Luciani, Dan S., Nislow, Corey, Rideout, Elizabeth J., Cytrynbaum, Eric N., Kim, Jason K., Bernal-Mizrachi, Ernesto, Alonso, Laura C., MacDonald, Patrick E., Johnson, James D.

“…Insulin receptor (Insr) protein is present at higher levels in pancreatic β-cells than in most other tissues, but the consequences of β-cell insulin resistance…”
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Nano-porous carbon wrapped SiC nanowires with tunable dielectric properties for electromagnetic applications by Duan, Li-qun, Xu, Chang, Dai, Xiao-qing, Xiong, Zi-ming, Zhang, Bo, Zhang, Zhong-wei, Cui, Chuan-an, Xie, A-ming, Wu, Fan

“…In this work, SiC nanowires core and nano-porous carbon shell (SiC@C) was synthesized successfully via direct surface carbonization of SiC without any…”
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A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding by Lin, Haopeng, Suzuki, Kunimasa, Smith, Nancy, Li, Xi, Nalbach, Lisa, Fuentes, Sonia, Spigelman, Aliya F., Dai, Xiao-Qing, Bautista, Austin, Ferdaoussi, Mourad, Aggarwal, Saloni, Pepper, Andrew R., Roma, Leticia P., Ampofo, Emmanuel, Li, Wen-hong, MacDonald, Patrick E.

“…Pancreatic β-cells respond to metabolic stress by upregulating insulin secretion, however the underlying mechanisms remain unclear. Here we show, in β-cells…”
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Metabolomics applied to islet nutrient sensing mechanisms by Jensen, Mette V., Gooding, Jessica R., Ferdaoussi, Mourad, Dai, Xiao‐Qing, Peterson, Brett S., MacDonald, Patrick E., Newgard, Christopher B.

“…After multiple decades of investigation, the precise mechanisms involved in fuel‐stimulated insulin secretion are still being revealed. One avenue for gaining…”
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SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans by DAI, Xiao-Qing, PLUMMER, Greg, CASIMIR, Marina, YOUHOU KANG, HAJMRLE, Catherine, GAISANO, Herbert Y, MANNING FOX, Jocelyn E, MACDONALD, Patrick E

“…The reversible attachment of small ubiquitin-like modifier (SUMO) proteins controls target localization and function. We examined an acute role for the…”
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Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules by KRUIT, Janine K, WIJESEKARA, Nadeeja, JOHNSON, James D, LIGHT, Peter E, MARSH, Brad J, MACDONALD, Patrick E, BRUCE VERCHERE, C, HAYDEN, Michael R, MANNING FOX, Jocelyn E, DAI, Xiao-Qing, BRUNHAM, Liam R, SEARLE, Gavin J, MORGAN, Garry P, COSTIN, Adam J, RENMEI TANG, BHATTACHARJEE, Alpana

“…The ATP-binding cassette transporter A1 (ABCA1) is essential for normal insulin secretion from β-cells. The aim of this study was to elucidate the mechanisms…”
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SUMO1 enhances cAMP‐dependent exocytosis and glucagon secretion from pancreatic α‐cells by Dai, Xiao‐Qing, Spigelman, Aliya F., Khan, Shara, Braun, Matthias, Manning Fox, Jocelyn E., MacDonald, Patrick E.

“…Key points SUMOylation is the reversible modification of proteins by the attachment of small ubiquitin‐like modifier (SUMO) peptides, which in pancreatic…”
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Structural interaction and functional regulation of polycystin-2 by filamin by Wang, Qian, Dai, Xiao-Qing, Li, Qiang, Wang, Zuocheng, Cantero, María del Rocío, Li, Shu, Shen, Ji, Tu, Jian-Cheng, Cantiello, Horacio, Chen, Xing-Zhen

“…Filamins are important actin cross-linking proteins implicated in scaffolding, membrane stabilization and signal transduction, through interaction with ion…”
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Combinatorial transcription factor profiles predict mature and functional human islet α and β cells by Shrestha, Shristi, Saunders, Diane C, Walker, John T, Camunas-Soler, Joan, Dai, Xiao-Qing, Haliyur, Rachana, Aramandla, Radhika, Poffenberger, Greg, Prasad, Nripesh, Bottino, Rita, Stein, Roland, Cartailler, Jean-Philippe, Parker, Stephen Cj, MacDonald, Patrick E, Levy, Shawn E, Powers, Alvin C, Brissova, Marcela

“…Islet-enriched transcription factors (TFs) exert broad control over cellular processes in pancreatic α and β cells, and changes in their expression are…”
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Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin by Wu, Yuliang, Dai, Xiao-Qing, Li, Qiang, Chen, Carl X., Mai, Weiyi, Hussain, Zahir, Long, Wentong, Montalbetti, Nicolás, Li, Guochun, Glynne, Richard, Wang, Shaohua, Cantiello, Horacio F., Wu, Guanqing, Chen, Xing-Zhen

“…Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1, encoding polycystin-1 (PC1), or PKD2 (polycystin-2, PC2). Autosomal…”
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Inhibition of TRPP3 channel by amiloride and analogs by Dai, Xiao-Qing, Ramji, Alkarim, Liu, Yan, Li, Qiang, Karpinski, Edward, Chen, Xing-Zhen

“…TRPP3, a member of the transient receptor potential (TRP) superfamily of cation channels, is a Ca2+-activated channel permeable to Ca2+, Na+, and K+. TRPP3 has…”
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Alpha-actinin associates with polycystin-2 and regulates its channel activity by Li, Qiang, Montalbetti, Nicolás, Shen, Patrick Y., Dai, Xiao-Qing, Cheeseman, Christopher I., Karpinski, Edward, Wu, Guanqing, Cantiello, Horacio F., Chen, Xing-Zhen

“…Polycystin-2 (PC2) is the product of the PKD2 gene, which is mutated in 10–15% patients of autosomal dominant polycystic kidney disease (ADPKD). PC2 is an…”
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Direct binding of α-actinin enhances TRPP3 channel activity by Li, Qiang, Dai, Xiao-Qing, Shen, Patrick Y, Wu, Yuliang, Long, Wentong, Chen, Carl X, Hussain, Zahir, Wang, Shaohua, Chen, Xing-Zhen

“…Transient receptor potential (TRP) polycystin 2 and 3 (TRPP2 and 3) are homologous members of the TRP superfamily of cation channels but have different…”
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Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease by Koppe, Laetitia, Nyam, Elsa, Vivot, Kevin, Manning Fox, Jocelyn E, Dai, Xiao-Qing, Nguyen, Bich N, Trudel, Dominique, Attané, Camille, Moullé, Valentine S, MacDonald, Patrick E, Ghislain, Julien, Poitout, Vincent

“…Disorders of glucose homeostasis are common in chronic kidney disease (CKD) and are associated with increased mortality, but the mechanisms of impaired insulin…”
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Protocatechuic acid inhibits hepatitis B virus replication by activating ERK1/2 pathway and down-regulating HNF4α and HNF1α in vitro by Dai, Xiao-Qing, Cai, Wen-Tao, Wu, Xiao, Chen, Yong, Han, Feng-Mei

“…Protocatechuic acid (PCA) is a phenolic compound found in many antiviral Chinese herbal medicines. HNF4α and HNF1α, the members of hepatocyte nuclear factor…”
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Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes by Wang, Gaowei, Chiou, Joshua, Zeng, Chun, Miller, Michael, Matta, Ileana, Han, Jee Yun, Kadakia, Nikita, Okino, Mei-Lin, Beebe, Elisha, Mallick, Medhavi, Camunas-Soler, Joan, dos Santos, Theodore, Dai, Xiao-Qing, Ellis, Cara, Hang, Yan, Kim, Seung K., MacDonald, Patrick E., Kandeel, Fouad R., Preissl, Sebastian, Gaulton, Kyle J., Sander, Maike

“…Dysfunctional pancreatic islet beta cells are a hallmark of type 2 diabetes (T2D), but a comprehensive understanding of the underlying mechanisms, including…”
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Cytoskeletal regulation of calcium-permeable cation channels in the human syncytiotrophoblast: role of gelsolin by Montalbetti, Nicolás, Li, Qiang, Timpanaro, Gustavo A., González‐Perrett, Silvia, Dai, Xiao‐Qing, Chen, Xing‐Zhen, Cantiello, Horacio F.

“…The human syncytiotrophoblast (hST) is the most apical epithelial barrier that covers the villous tree of the human placenta. An intricate and highly organized…”
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Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion by Bozadjieva, Nadejda, Blandino-Rosano, Manuel, Chase, Jennifer, Dai, Xiao-Qing, Cummings, Kelsey, Gimeno, Jennifer, Dean, Danielle, Powers, Alvin C, Gittes, George K, Rüegg, Markus A, Hall, Michael N, MacDonald, Patrick E, Bernal-Mizrachi, Ernesto

“…Glucagon plays a major role in the regulation of glucose homeostasis during fed and fasting states. However, the mechanisms responsible for the regulation of…”
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