Search Results - "Dai, Wei‐Chen"

Research strategies of small molecules as chemotherapeutics to overcome multiple myeloma resistance by Yang, Jin, Yu, Yan-Cheng, Wang, Zi-Xuan, Li, Qing-Qing, Ding, Ning, Leng, Xue-Jiao, Cai, Jiao, Zhang, Meng-Yuan, Wang, Jing-Jing, Zhou, Yun, Wei, Tian-Hua, Xue, Xin, Dai, Wei-Chen, Sun, Shan-Liang, Yang, Ye, Li, Nian-Guang, Shi, Zhi-Hao

“…Multiple myeloma (MM), a cancer of plasma cells, is the second most common hematological malignancy which is characterized by aberrant plasma cells…”
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Design and synthesis 1H-Pyrrolo[2,3-b]pyridine derivatives as FLT3 inhibitors for the treatment of Acute myeloid Leukemia by Wei, Tian-Hua, Zhou, Yun, Yang, Jin, Zhang, Meng-Yuan, Wang, Jing-Jing, Tong, Zhen-Jiang, Wu, Jia-Zhen, Wang, Yi-Bo, Sha, Jiu-Kai, Chen, Min, Ding, Ning, Yu, Yan-Cheng, Dai, Wei-Chen, Leng, Xue-Jiao, Xue, Xin, Sun, Shan-Liang, Wang, Xiao-Long, Li, Nian-Guang, Shi, Zhi-Hao

“…[Display omitted] Acute myeloid leukemia (AML) is the most common type of blood cancer and has been strongly correlated with the overexpression of Fms-like…”
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Exploring drug repositioning possibilities of kinase inhibitors via molecular simulation by Wang, Qing‐Xin, Cai, Jiao, Chen, Zi‐Jun, Liu, Jia‐Chuan, Wang, Jing‐Jing, Zhou, Hai, Li, Qing‐Qing, Wang, Zi‐Xuan, Wang, Yi‐Bo, Tong, Zhen‐Jiang, Yang, Jin, Wei, Tian‐Hua, Zhang, Meng‐Yuan, Zhou, Yun, Dai, Wei‐Chen, Ding, Ning, Leng, Xue‐Jiao, Yin, Xiao‐Ying, Sun, Shan‐Liang, Yu, Yan‐Cheng, Li, Nian‐Guang, Shi, Zhi‐Hao

“…Kinases, a class of enzymes controlling various substrates phosphorylation, are pivotal in both physiological and pathological processes. Although their…”
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Preclinical characterization of danatinib as a novel FLT3 inhibitor with excellent efficacy against resistant acute myeloid leukemia by Sun, Shan-Liang, Wu, Jia-Zhen, Wang, Jing-Jing, Zhou, Hai, Zhang, Chen-Qian, Tong, Zhen-Jiang, Wang, Yi-Bo, Sha, Jiu-Kai, Wang, Qing-Xin, Liu, Jia-Chuan, Zheng, Xin-Rui, Li, Qing-Qing, Zhang, Meng-Yuan, Yang, Jin, Wei, Tian-Hua, Wang, Zi-Xuan, Yu, Yan-Cheng, Ding, Ning, Leng, Xue-Jiao, Xue, Xin, Li, He-Min, Dai, Wei-Chen, Yin, Xiao-Ying, Yang, Ye, Duan, Jin-Ao, Li, Nian-Guang, Shi, Zhi-Hao

“…The therapeutic benefits of available FLT3 inhibitors for AML are limited by drug resistance, which is related to mutations, as well toxicity caused by…”
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Discovery of 4‐(4‐aminophenyl)‐6‐phenylisoxazolo[3,4‐b]pyridine‐3‐amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia by Wang, Qing‐Xin, Wang, Yi‐Bo, Sha, Jiu‐Kai, Zhou, Hai, Liu, Jia‐Chuan, Wu, Jia‐Zhen, Tong, Zhen‐Jiang, Cai, Jiao, Chen, Zi‐Jun, Zhang, Chen‐Qian, Zheng, Xin‐Rui, Wang, Jing‐Jing, Wang, Xiao‐Long, Xue, Xin, Yu, Yan‐Cheng, Ding, Ning, Leng, Xue‐Jiao, Dai, Wei‐Chen, Sun, Shan‐Liang, Chang, Liang, Li, Nian‐Guang, Shi, Zhi‐Hao

“…Small molecule covalent drugs have proved to be desirable therapies especially on drug resistance related to point mutations. Secondary mutations of FLT3 have…”
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Development of Orally Active Thrombin Inhibitors for the Treatment of Thrombotic Disorder Diseases by He, Li-Wei, Dai, Wei-Chen, Li, Nian-Guang

“…Thrombotic disorders represent the major share of the various cardiovascular diseases, and significant progress has been made in the development of synthetic…”
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Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics by Wei, Tian‐Hua, Lu, Meng‐Yi, Yao, Si‐Hui, Hong, Yu‐Qi, Yang, Jin, Zhang, Meng‐Yuan, Yin, Yu‐Qi, Han, Yu‐Jie, Li, Qing‐Qing, Wang, Zi‐Xuan, Wang, Yi‐Bo, Tong, Zhen‐Jiang, Zhou, Yun, Dai, Wei‐Chen, Yu, Yan‐Cheng, Sun, Shan‐Liang, Yang, Ye, Li, Nian‐Guang, Shi, Zhi‐Hao

“…Janus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited…”
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Immobilization of calcium oxide onto chitosan beads as a heterogeneous catalyst for biodiesel production by Fu, Chun-Chong, Hung, Tien-Chieh, Su, Chia-Hung, Suryani, Devi, Wu, Wen-Teng, Dai, Wei-Chen, Yeh, Yea-Tyam

“…A biopolymer, chitosan, was used as a novel substrate for the immobilization of calcium oxide (CaO). CaO immobilized onto chitosan beads was employed as a…”
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Grinding temperature and power consumption in high speed grinding of Inconel 718 nickel-based superalloy with a vitrified CBN wheel by Dai, Chen-Wei, Ding, Wen-Feng, Zhu, Ye-Jun, Xu, Jiu-Hua, Yu, Hai-Wu

“…•High speed grinding of Inconel 718 superalloy was carried out using a vitrified CBN wheel.•Effects of wheel speed on grinding temperature and heat partition…”
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Single diamond grain cutting-edges morphology effect on grinding mechanism of Inconel 718 by Dai, Chen-Wei, Yu, Tian-Yu, Ding, Wen-Feng, Xu, Jiu-Hua, Yin, Zhen, Li, Hua

“…This study is focusing on exploring the effect of diamond grain cutting-edges morphology and grinding wheel speed on grinding performance of nickel-based…”
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Unraveling the Promise of RET Inhibitors in Precision Cancer Therapy by Targeting RET Mutations by Wang, Zi-Xuan, Li, Qing-Qing, Cai, Jiao, Wu, Jia-Zhen, Wang, Jing-Jing, Zhang, Meng-Yuan, Wang, Qing-Xin, Tong, Zhen-Jiang, Yang, Jin, Wei, Tian-Hua, Zhou, Yun, Dai, Wei-Chen, Ding, Ning, Leng, Xue-Jiao, Sun, Shan-Liang, Xue, Xin, Yu, Yan-Cheng, Yang, Ye, Li, Nian-Guang, Shi, Zhi-Hao

“…Over the past decades, the role of rearranged during transfection (RET) alterations in tumorigenesis has been firmly established. RET kinase inhibition is an…”
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Synthesis and biological evaluation of 4-(4-aminophenyl)-6-methylisoxazolo[3,4-b] pyridin-3-amine covalent inhibitors as potential agents for the treatment of acute myeloid leukemia by Kang, Ji-Bo, Chen, Lu, Leng, Xue-Jiao, Wang, Jing-Jing, Cheng, Yang, Wu, Shi-Han, Ma, Yi-Yuan, Yang, Li-Jin, Cao, Yu-Hao, Yang, Xiao, Tong, Zhen-Jiang, Wu, Jia-Zhen, Wang, Yi-Bo, Zhou, Hai, Liu, Jia-Chuan, Ding, Ning, Dai, Wei-Chen, Yu, Yan-Cheng, Xue, Xin, Sun, Shan-Liang, Dai, Xiao-Bin, Chang, Liang, Wang, Xiao-Long, Li, Nian-Guang, Shi, Zhi-Hao

“…[Display omitted] •A series of 4-(4-aminophenyl)-6-methylisoxazolo[3,4-b] pyridin-3-amine derivatives as FLT3 covalent inhibitors were designed and…”
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Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II by Wang, Qing-Xin, Cao, Yu-Hao, Yang, Li-Jin, Ma, Yi-Yuan, Li, Nan, Wu, Shi-Han, Chen, Lu, Wu, Jia-Zhen, Tong, Zhen-Jiang, Wang, Xiao-Long, Xue, Xin, Ding, Ning, Leng, Xue-Jiao, Chang, Liang, Dai, Wei-Chen, Yu, Yan-Cheng, Sun, Shan-Liang, Yang, Ye, Li, Nian-Guang, Shi, Zhi-Hao

“…The clinical benefits of FLT3 inhibitors against acute myeloid leukemia (AML) have been limited by selectivity and resistance mutations. Thus, to identify FLT3…”
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Lipase-catalyzed synthesis of butyl propionate in solvent-free system: Optimization by response surface methodology by Dai, Wei-Chen, Chiu, Shwu-Jer, Huang, Dao-Yi, Juan, Horng-Yi, Chen, Cheng-Yu, Chen, Shang-Shian, Su, Chia-Hung, Li, Sing-Ying

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Discovery of SILA-123 as a Highly Potent FLT3 Inhibitor for the Treatment of Acute Myeloid Leukemia with Various FLT3 Mutations by Wei, Tian-Hua, Wang, Zi-Xuan, Lu, Meng-Yi, Xu, Yu-Jing, Yang, Jin, Ni, Xing-Feng, Cheng, Yang, Zhang, Meng-Yuan, Liu, Jia-Chuan, Li, Qing-Qing, Cai, Jiao, Chen, Zi-Jun, Kang, Ji-Bo, Li, Nan, Dai, Wei-Chen, Ding, Ning, Yu, Yan-Cheng, Leng, Xue-Jiao, Xue, Xin, Wang, Xiao-Long, Sun, Shan-Liang, Yang, Ye, Li, Nian-Guang, Shi, Zhi-Hao

“…The FLT3-ITD (internal tandem duplication) mutant has been a promising target for acute myeloid leukemia (AML) drug discovery but is now facing the challenge…”
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Discovery of 1-(Phenylsulfonyl)-1,2,3,4-tetrahydroquinoline Derivative as Orally Bioavailable and Safe RORγt Inverse Agonists for Potential Treatment of Rheumatoid Arthritis by Sun, Shan-Liang, Xu, Hong-Jiang, Jiang, Xiao-Long, Zhou, Jian, Shi, Wei, Wang, Xiao-Jin, Song, Wei, Chang, Xia-Yun, Ma, Xue-Qin, Zou, Xiao-Fang, Wu, Shi-Han, Yang, Jin, Li, Qing-Qing, Wang, Zi-Xuan, Cai, Jiao, Yu, Shao-Peng, Wang, Qing-Xin, Wei, Tian-Hua, Wu, Jia-Zhen, Tong, Zhen-Jiang, Zhou, Yun, Wang, Yi-Bo, Yu, Yan-Cheng, Leng, Xue-Jiao, Ding, Ning, Shi, Zhi-Hao, Dai, Wei-Chen, Xue, Xin, Li, Nian-Guang, Wang, Xiao-Long

“…The retinoic acid receptor-related orphan receptor γt (RORγt) is a key regulator of Th17 cells, associated with autoimmune diseases, making it a significant…”
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Discovery of 4‐(4‐aminophenyl)‐6‐phenylisoxazolopyridine‐3‐amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia by Qing‐Xin Wang, Yi‐Bo Wang, Jiu‐Kai Sha, Zhou, Hai, Jia‐Chuan Liu, Jia‐Zhen Wu, Zhen‐Jiang Tong, Jiao Cai, Zi‐Jun Chen, Chen‐Qian Zhang, Xin‐Rui Zheng, Jing‐Jing Wang, Xiao‐Long Wang, Xue, Xin, Yan‐Cheng Yu, Ding, Ning, Xue‐Jiao Leng, Wei‐Chen Dai, Shan‐Liang Sun, Chang, Liang, Nian‐Guang Li, Zhi‐Hao Shi

“…Small molecule covalent drugs have proved to be desirable therapies especially on drug resistance related to point mutations. Secondary mutations of FLT3 have…”
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Prognostic value of high-sensitivity cardiac troponin T in patients with en-domyocardial-biopsy proven cardiac amyloidosis by Geng QIAN Chen WU Yang ZHANG Yun-Dai CHEN Wei DONG Yi-Hong REN

“…Objective To investigate prognostic predictors of long-term survival of patients with cardiac amyloidosis （CA）, and to determine predictive value of…”
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Catalyst-free hydrochlorination protocol for terminal arylalkynes with hydrogen chloride by Xu, Cai-Xia, Ma, Cun-Hua, Xiao, Fu-Rong, Chen, Hong-Wei, Dai, Bin

“…We present a simple and straightforward protocol for hydrochlorination of terminal arylalkynes to vinyl chlorides using hydrogen chloride under mild reaction…”
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Catalyst-free hydrochlorination protocol for terminal arylalkynes with hydrogen chloride by Cai-Xia Xu Cun-Hua Ma Fu-Rong Xiao Hong-Wei Chen Bin Dai

“…We present a simple and straightforward protocol for hydrochlorination of terminal arylalkynes to vinyl chlorides using hydrogen chloride under mild reaction…”
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