Search Results - "Dai, PeiMin"
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A combined strategy of mass fragmentation, post-column cobalt complexation and shift in ultraviolet absorption spectra to determine the uridine 5′-diphospho-glucuronosyltransferase metabolism profiling of flavones after oral administration of a flavone mixture in rats
Published in Journal of Chromatography A (22-05-2015)“…•Development of a novel strategy for identification of positions of glucuronidation sites of flavones using UPLC–DAD–Q-TOF.•Twelve flavone glucuronides were…”
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Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes
Published in Biopharmaceutics & drug disposition (01-12-2015)“…Flavonoids occur naturally as glucosides and aglycones. Their common phenolic hydroxyl groups may trigger extensive UDP‐glucuronosyltransferase (UGT)‐…”
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Triple Recycling Processes Impact Systemic and Local Bioavailability of Orally Administered Flavonoids
Published in The AAPS journal (01-05-2015)“…Triple recycling ( i.e. , enterohepatic, enteric and local recycling) plays a central role in governing the disposition of phenolics such as flavonoids,…”
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Multidrug resistance-associated protein 2 is involved in the efflux of Aconitum alkaloids determined by MRP2-MDCKII cells
Published in Life sciences (1973) (15-04-2015)“…Aconitum alkaloids mainly contain highly toxic aconitine (AC), mesaconitine (MA), and hypaconitine (HA) and less toxic benzoylaconine (BAC), benzoylmesaconine…”
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UDP-Glucuronosyltransferases 1A6 and 1A9 are the Major Isozymes Responsible for the 7-O-Glucuronidation of Esculetin and 4-Methylesculetin in Human Liver Microsomes
Published in Drug metabolism and disposition (01-07-2015)“…Esculetin (6,7-dihydroxycoumarin, ET) and 4-methylesculetin (6,7-dihydroxy-4-methylcoumarin, 4-ME) are typical coumarin derivatives that are attracting…”
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A pilot study on transient ischemic stroke induced with endothelin-1 in the rhesus monkeys
Published in Scientific reports (30-03-2017)“…Endothelin-1 (ET-1), a vasoconstrictor, has recently been used to induce focal ischemia in rodents and marmoset monkeys. The rhesus monkey, however, has…”
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