Search Results - "Dai, Mingji"

Total Syntheses of the Reported Structures of Curcusones I and J through Tandem Gold Catalysis by Li, Yong, Dai, Mingji

“…Total syntheses of the reported structures of the rhamnofolane diterpene natural products curcusones I and J in racemic form were achieved. The synthetic…”
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11-Step and Scalable Total Synthesis of Hamigeran M Enabled by Five C–H Functionalizations by Jiang, Baiyang, Dai, Mingji

“…We report the convergent total synthesis of (±)-hamigeran M, enabled by five C–H functionalization reactions and proceeding in 11 steps in 3.9% overall yield…”
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Total Syntheses of Bisdehydroneostemoninine and Bisdehydrostemoninine by Catalytic Carbonylative Spirolactonization by Ma, Kaiqing, Yin, Xianglin, Dai, Mingji

“…The first total syntheses of the stemona alkaloids bisdehydroneostemoninine and bisdehydrostemoninine in racemic forms have been achieved. The synthetic…”
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Natural Product Synthesis via Palladium-Catalyzed Carbonylation by Bai, Yu, Davis, Dexter C, Dai, Mingji

“…Carbon monoxide is an important one-carbon source and can be incorporated in complex molecules via various transition-metal-catalyzed carbonylation reactions…”
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Total Synthesis of (−)-Spinosyn A via Carbonylative Macrolactonization by Bai, Yu, Shen, Xingyu, Li, Yong, Dai, Mingji

“…Spinosyn A (1), a complex natural product featuring a unique 5,6,5,12-fused tetracyclic core structure, is the major component of spinosad, an organic…”
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Biosynthetically Inspired Divergent Approach to Monoterpene Indole Alkaloids: Total Synthesis of Mersicarpine, Leuconodines B and D, Leuconoxine, Melodinine E, Leuconolam, and Rhazinilam by Yang, Yang, Bai, Yu, Sun, Siyuan, Dai, Mingji

“…Inspired by their potential biosynthesis, we have developed divergent total syntheses of seven monoterpene indole alkaloids including mersicarpine,…”
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Catalytic Hydroxycyclopropanol Ring-Opening Carbonylative Lactonization to Fused Bicyclic Lactones by Cai, Xinpei, Liang, Weida, Liu, Mingxin, Li, Xiating, Dai, Mingji

“…A novel palladium-catalyzed ring opening carbonylative lactonization of readily available hydroxycyclopropanols was developed to efficiently synthesize…”
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Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes by Ye, Zhishi, Adhikari, Sarju, Xia, Yu, Dai, Mingji

“…Saturated 1,4-diazo heterocycles including piperazines, 1,4-diazepanes, and 1,4-diazocanes, are highly important for therapeutic development, but their…”
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High-throughput screening identifies a novel natural product-inspired scaffold capable of inhibiting Clostridioides difficile in vitro by Pal, Rusha, Dai, Mingji, Seleem, Mohamed N.

“…Clostridioides difficile is an enteric pathogen responsible for causing debilitating diarrhea, mostly in hospitalized patients. The bacterium exploits on…”
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One-Carbon Insertion and Polarity Inversion Enabled a Pyrrole Strategy to the Total Syntheses of Pyridine-Containing Lycopodium Alkaloids: Complanadine A and Lycodine by Ma, Donghui, Martin, Brandon S, Gallagher, Katelyn S, Saito, Takeru, Dai, Mingji

“…Complanadine A and lycodine are representative members of the Lycopodium alkaloids with a characteristic pyridine-containing tetracyclic skeleton. Complanadine…”
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Gold catalysis-facilitated rapid synthesis of the daphnane/tigliane tricyclic core by Li, Yong, Wei, Mufeng, Dai, Mingji

“…A concise approach to synthesize the 5-7-6 tricyclic carbon skeleton of the daphnane/tigliane diterpene natural products has been accomplished via a sequential…”
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Catalytic Carbonylative Spirolactonization of Hydroxycyclopropanols by Davis, Dexter C, Walker, Katherine L, Hu, Chunhua, Zare, Richard N, Waymouth, Robert M, Dai, Mingji

“…A palladium-catalyzed cascade carbonylative spirolactonization of hydroxycyclopropanols has been developed to efficiently synthesize oxaspirolactones common to…”
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Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs by Adams, Drew J, Dai, Mingji, Pellegrino, Giovanni, Wagner, Bridget K, Stern, Andrew M, Shamji, Alykhan F, Schreiber, Stuart L

“…Piperlongumine is a naturally occurring small molecule recently identified to be toxic selectively to cancer cells in vitro and in vivo. This compound was…”
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Synthesis of Tetrahydropyran/Tetrahydrofuran-Containing Macrolides by Palladium-Catalyzed Alkoxycarbonylative Macrolactonizations by Bai, Yu, Davis, Dexter C., Dai, Mingji

“…A novel Pd‐catalyzed cascade alkoxycarbonylative macrolactonization to construct tetrahydropyran/tetrahydrofuran‐containing bridged macrolactones in one step…”
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Total Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation by Luo, Yiyang, Yin, Xianglin, Dai, Mingji

“…The resorcylic macrolides are important natural products with a wide range of remarkable biological activities. So far, most of the reported resorcylic…”
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Modular and practical diamination of allenes by Dai, Jian-Jun, Yin, Xianglin, Li, Lei, Rivera, Mario E., Wang, Ye-Cheng, Dai, Mingji

“…Vicinal diamines are privileged scaffolds in medicine, agrochemicals, catalysis, and other fields. While significant advancements have been made in diamination…”
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Assessing Cholesterol Storage in Live Cells and C. elegans by Stimulated Raman Scattering Imaging of Phenyl-Diyne Cholesterol by Lee, Hyeon Jeong, Zhang, Wandi, Zhang, Delong, Yang, Yang, Liu, Bin, Barker, Eric L., Buhman, Kimberly K., Slipchenko, Lyudmila V., Dai, Mingji, Cheng, Ji-Xin

“…We report a cholesterol imaging method using rationally synthesized phenyl-diyne cholesterol (PhDY-Chol) and stimulated Raman scattering (SRS) microscope. The…”
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Total Synthesis and Target Identification of the Curcusone Diterpenes by Cui, Chengsen, Dwyer, Brendan G, Liu, Chang, Abegg, Daniel, Cai, Zhong-Jian, Hoch, Dominic G, Yin, Xianglin, Qiu, Nan, Liu, Jie-Qing, Adibekian, Alexander, Dai, Mingji

“…The curcusone natural products are complex diterpenes featuring a characteristic [6–7–5] tricyclic carbon skeleton similar to the daphnane and tigliane…”
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Catalysis‐Enabled Concise and Stereoselective Total Synthesis of the Tricyclic Prostaglandin D2 Metabolite Methyl Ester by Sims, Hunter S., Andrade Horn, Pedro, Isshiki, Ryota, Lim, Melissa, Xu, Yan, Grubbs, Robert H., Dai, Mingji

“…A concise and stereoselective total synthesis of the clinically relevant tricyclic prostaglandin D2 metabolite (tricyclic‐PGDM) methyl ester in racemic form…”
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Opportunities and challenges for direct C-H functionalization of piperazines by Ye, Zhishi, Gettys, Kristen E, Dai, Mingji

“…Piperazine ranks within the top three most utilized N-heterocyclic moieties in FDA-approved small-molecule pharmaceuticals. Herein we summarize the current…”
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