Search Results - "Dai, Jixun"

Polymorphism of human telomeric quadruplex structures by Dai, Jixun, Carver, Megan, Yang, Danzhou

“…Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG). Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the…”
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Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation by Dai, Jixun, Punchihewa, Chandanamali, Ambrus, Attila, Chen, Ding, Jones, Roger A, Yang, Danzhou

“…We report the NMR solution structure of the intramolecular G-quadruplex formed in human telomeric DNA in K⁺. The hybrid-type telomeric G-quadruplex consists of…”
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Solution Structure of the Biologically Relevant G-Quadruplex Element in the Human c-MYC Promoter. Implications for G-Quadruplex Stabilization by Ambrus, Attila, Chen, Ding, Dai, Jixun, Jones, Roger A., Yang, Danzhou

“…The nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter strongly controls the transcriptional activity of the c-MYC oncogene. The…”
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NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region by Dai, Jixun, Chen, Ding, Jones, Roger A, Hurley, Laurence H, Yang, Danzhou

“…BCL2 protein functions as an inhibitor of cell apoptosis and has been found to be aberrantly expressed in a wide range of human diseases. A highly GC-rich…”
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An Intramolecular G-Quadruplex Structure with Mixed Parallel/Antiparallel G-Strands Formed in the Human BCL-2 Promoter Region in Solution by Dai, Jixun, Dexheimer, Thomas S, Chen, Ding, Carver, Megan, Ambrus, Attila, Jones, Roger A, Yang, Danzhou

“…We report the first G-quadruplex structure formed in the promoter region of the human bcl-2. Bcl-2 is a potent oncoprotein that functions as an inhibitor of…”
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I-motif structures formed in the human c-MYC promoter are highly dynamic--insights into sequence redundancy and I-motif stability by Dai, Jixun, Hatzakis, Emmanuel, Hurley, Laurence H, Yang, Danzhou

“…The GC-rich nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter largely controls the transcriptional activity of the c-MYC oncogene. The…”
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A Direct and Nondestructive Approach To Determine the Folding Structure of the I-Motif DNA Secondary Structure by NMR by Dai, Jixun, Ambrus, Attila, Hurley, Laurence H, Yang, Danzhou

“…I-motifs are four-stranded DNA secondary structures formed in C-rich DNA sequences and consist of parallel-stranded DNA duplexes zipped together in an…”
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Novel DNA Bis-intercalation by MLN944, a Potent Clinical Bisphenazine Anticancer Drug by Dai, Jixun, Punchihewa, Chandanamalie, Mistry, Prakash, Ooi, Aik Teong, Yang, Danzhou

“…The new bisphenazine anticancer drug MLN944 is a novel cytotoxic agent with exceptional anti-tumor activity against a range of human and murine tumor models…”
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Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes by Dickerhoff, Jonathan, Dai, Jixun, Yang, Danzhou

“…Abstract DNA G-Quadruplexes (G4s) formed in oncogene promoters regulate transcription. The oncogene MYC promoter G4 (MycG4) is the most prevalent G4 in human…”
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c-MYC promoter G-quadruplex formed at the 5′-end of NHE III 1 element: insights into biological relevance and parallel-stranded G-quadruplex stability by Mathad, Raveendra I., Hatzakis, Emmanuel, Dai, Jixun, Yang, Danzhou

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An Improved Method for Karyotype Analyses of Marine Algae by Wang, Juan, Dai, Jixun

“…Modified carbol fuchsin staining method was successfully introduced into the karyotype analyses of mar/ne algae, including Porphyra, Undaria pinnatifida and…”
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Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design by Dai, Jixun, Carver, Megan, Hurley, Laurence H, Yang, Danzhou

“…Unimolecular parallel-stranded G-quadruplex structures are found to be prevalent in gene promoters. The nuclease hypersensitivity element III1 (NHE III1) of…”
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Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition by Liu, Wenting, Lin, Clement, Wu, Guanhui, Dai, Jixun, Chang, Ta-Chau, Yang, Danzhou

“…BMVC is the first fluorescent probe designed to detect G-quadruplexes (G4s) in vivo. The MYC oncogene promoter forms a G4 (MycG4) which acts as a transcription…”
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Nuclear division of the vegetative cells, conchosporangial cells and conchospores of Porphyra yezoensis (Bangiales, Rhodophyta) by Wang, Juan, Dai, Jixun, Zhang, Yiting

“…SUMMARY To confirm the position and timing of meiosis in Porphyra yezoensis Ueda, the nuclear division of vegetative cells, conchosporangial cells and…”
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c-MYC promoter G-quadruplex formed at the 5′-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability by Mathad, Raveendra I., Hatzakis, Emmanuel, Dai, Jixun, Yang, Danzhou

“…We studied the structures and stabilities of G-quadruplexes formed in Myc1234, the region containing the four consecutive 5′ runs of guanines of c-MYC promoter…”
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Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K⁺ solution: insights into structure polymorphism of the human telomeric sequence by Dai, Jixun, Carver, Megan, Punchihewa, Chandanamali, Jones, Roger A, Yang, Danzhou

“…Formation of the G-quadruplex in the human telomeric sequence can inhibit the activity of telomerase, thus the intramolecular telomeric G-quadruplexes have…”
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Cryopreservation of protoplasts of the alga Porphyra yezoensis by vitrification by Liu, Hongquan, Yu, Wengong, Dai, Jixun, Gong, Qianhong, Yang, Kunfeng, Lu, Xinzhi

“…Protoplasts of Porphyra yezoensis were successfully cryopreserved at liquid nitrogen (LN) temperature by vitrification and subsequently regenerated into…”
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Abstract 3840: High-resolution structural insights into targeting the MYC oncogene G-quadruplex with the quinoline derivative PEQ by Dickerhoff, Jonathan, Dai, Jixun, Yang, Danzhou

“…Abstract The transcription of the MYC oncogene, a central player of oncogenesis, is strongly controlled by DNA G-quadruplexes in its promoter region (MycG4)…”
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Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K⁺ solution: insights into the interconversion of human telomeric G-quadruplex structures by Zhang, Zhenjiang, Dai, Jixun, Veliath, Elizabeth, Jones, Roger A, Yang, Danzhou

“…Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic…”
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Study on cryopreservation of Porphyra yezoensis conchocelis by Zhou, Wenjun, Li, Yun, Dai, Jixun

“…Cryopreservation of Porphyra yezoensis conchocelis was conducted with cryoprotectants and a proposed pretreatment procedure and thawing methods explored. Six…”
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