Search Results - "Dai, Feihan F."

Amino acid and lipid metabolism in post-gestational diabetes and progression to type 2 diabetes: A metabolic profiling study by Lai, Mi, Liu, Ying, Ronnett, Gabriele V, Wu, Anne, Cox, Brian J, Dai, Feihan F, Röst, Hannes L, Gunderson, Erica P, Wheeler, Michael B

“…Women with a history of gestational diabetes mellitus (GDM) have a 7-fold higher risk of developing type 2 diabetes (T2D) during midlife and an elevated risk…”
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A Predictive Metabolic Signature for the Transition From Gestational Diabetes Mellitus to Type 2 Diabetes by Allalou, Amina, Nalla, Amarnadh, Prentice, Kacey J, Liu, Ying, Zhang, Ming, Dai, Feihan F, Ning, Xian, Osborne, Lucy R, Cox, Brian J, Gunderson, Erica P, Wheeler, Michael B

“…Gestational diabetes mellitus (GDM) affects 3-14% of pregnancies, with 20-50% of these women progressing to type 2 diabetes (T2D) within 5 years. This study…”
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The Furan Fatty Acid Metabolite CMPF Is Elevated in Diabetes and Induces β Cell Dysfunction by Prentice, Kacey J., Luu, Lemieux, Allister, Emma M., Liu, Ying, Jun, Lucy S., Sloop, Kyle W., Hardy, Alexandre B., Wei, Li, Jia, Weiping, Fantus, I. George, Sweet, Douglas H., Sweeney, Gary, Retnakaran, Ravi, Dai, Feihan F., Wheeler, Michael B.

“…Gestational diabetes (GDM) results from failure of the β cells to adapt to increased metabolic demands; however, the cause of GDM and the extremely high rate…”
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Intensive lactation among women with recent gestational diabetes significantly alters the early postpartum circulating lipid profile: the SWIFT study by Zhang, Ziyi, Lai, Mi, Piro, Anthony L, Alexeeff, Stacey E, Allalou, Amina, Röst, Hannes L, Dai, Feihan F, Wheeler, Michael B, Gunderson, Erica P

“…Women with a history of gestational diabetes mellitus (GDM) have a 7-fold higher risk of developing type 2 diabetes (T2D). It is estimated that 20-50% of women…”
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Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes by Lai, Mi, Al Rijjal, Dana, Röst, Hannes L, Dai, Feihan F, Gunderson, Erica P, Wheeler, Michael B

“…Approximately, 35% of women with Gestational Diabetes (GDM) progress to Type 2 Diabetes (T2D) within 10 years. However, links between GDM and T2D are not well…”
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Rapid Elevation in CMPF May Act As a Tipping Point in Diabetes Development by Liu, Ying, Prentice, Kacey J., Eversley, Judith A., Hu, Cheng, Batchuluun, Battsetseg, Leavey, Katherine, Hansen, Jakob B., Wei, David W., Cox, Brian, Dai, Feihan F., Jia, Weiping, Wheeler, Michael B.

“…Prediabetes, a state of mild glucose intolerance, can persist for years before a sudden decline in beta cell function and rapid deterioration to overt…”
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Adaptive Changes in Glucose Homeostasis and Islet Function During Pregnancy: A Targeted Metabolomics Study in Mice by Zhang, Ziyi, Piro, Anthony L, Dai, Feihan F, Wheeler, Michael B

“…Pregnancy is a dynamic state involving multiple metabolic adaptions in various tissues including the endocrine pancreas. However, a detailed characterization…”
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The Identification of Novel Protein-Protein Interactions in Liver that Affect Glucagon Receptor Activity by Han, Junfeng, Zhang, Ming, Froese, Sean, Dai, Feihan F, Robitaille, Mélanie, Bhattacharjee, Alpana, Huang, Xinyi, Jia, Weiping, Angers, Stéphane, Wheeler, Michael B, Wei, Li

“…Glucagon regulates glucose homeostasis by controlling glycogenolysis and gluconeogenesis in the liver. Exaggerated and dysregulated glucagon secretion can…”
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Vascepa protects against high-fat diet-induced glucose intolerance, insulin resistance, and impaired β-cell function by Al Rijjal, Dana, Liu, Ying, Lai, Mi, Song, Youchen, Danaei, Zahra, Wu, Anne, Mohan, Haneesha, Wei, Li, Schopfer, Francisco J., Dai, Feihan F., Wheeler, Michael B.

“…Omega-3 fatty acid prescription drugs, Vascepa (≥96% eicosapentaenoic acid [EPA] ethyl ester) and Lovaza (46.5% EPA and 37.5% docosahexaenoic acid ethyl ester)…”
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Pancreatic β cell-selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis by Xu, Jie, Wijesekara, Nadeeja, Regeenes, Romario, Rijjal, Dana Al, Piro, Anthony L, Song, Youchen, Wu, Anne, Bhattacharjee, Alpana, Liu, Ying, Marzban, Lucy, Rocheleau, Jonathan V, Fraser, Paul E, Dai, Feihan F, Hu, Cheng, Wheeler, Michael B

“…GWAS have shown that the common R325W variant of SLC30A8 (ZnT8) increases the risk of type 2 diabetes (T2D). However, ZnT8 haploinsufficiency is protective…”
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The Neuronal Ca2+ Sensor Protein Visinin-like Protein-1 Is Expressed in Pancreatic Islets and Regulates Insulin Secretion by Dai, Feihan F., Zhang, Yi, Kang, Youhou, Wang, Qinghua, Gaisano, Herbert Y., Braunewell, Karl-Heinz, Chan, Catherine B., Wheeler, Michael B.

“…Visinin-like protein-1 (VILIP-1) is a member of the neuronal Ca2+ sensor protein family that modulates Ca2+-dependent cell signaling events. VILIP-1, which is…”
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Prolactin and Maternal Metabolism in Women With a Recent GDM Pregnancy and Links to Future T2D: The SWIFT Study by Zhang, Ziyi, Piro, Anthony L, Allalou, Amina, Alexeeff, Stacey E, Dai, Feihan F, Gunderson, Erica P, Wheeler, Michael B

“…Prolactin is a multifaceted hormone known to regulate lactation. In women with gestational diabetes mellitus (GDM) history, intensive lactation has been…”
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GABA promotes β‐cell proliferation, but does not overcome impaired glucose homeostasis associated with diet‐induced obesity by Untereiner, Ashley, Abdo, Shaaban, Bhattacharjee, Alpana, Gohil, Himaben, Pourasgari, Farzaneh, Ibeh, Neke, Lai, Mi, Batchuluun, Battsetseg, Wong, Anthony, Khuu, Nicholas, Liu, Ying, Rijjal, Dana Al, Winegarden, Neil, Virtanen, Carl, Orser, Beverley A., Cabrera, Over, Varga, Gabor, Rocheleau, Jonathan, Dai, Feihan F., Wheeler, Michael B.

“…ABSTRACT γ‐Aminobutyric acid (GABA) administration has been shown to increase β‐cell mass, leading to a reversal of type 1 diabetes in mice. Whether GABA has…”
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γ‐aminobutyric acid stimulates β‐cell proliferation through the mTORC1/p70S6K pathway, an effect amplified by Ly49, a novel γ‐aminobutyric acid type A receptor positive allosteric modulator by Untereiner, Ashley, Xu, Jie, Bhattacharjee, Alpana, Cabrera, Over, Hu, Cheng, Dai, Feihan F., Wheeler, Michael B.

“…Aim To examine the mechanism of action of γ‐aminobutyric acid (GABA) on β‐cell proliferation and investigate if co‐treatment with Ly49, a novel GABA type A…”
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Beta cell specific ZnT8 gene deficiency and resulting loss in zinc content significantly improve insulin secretion by Piro, Anthony, Luo, Yihan, Zhang, Ziyi, Ye, Wenyue, Kang, Fei, Xie, Li, Wang, Yufeng, Dai, Feihan F., Gaisano, Herbert Y., Rocheleau, Jonathan V., Prentice, Kacey J., Wheeler, Michael B.

“…Zinc transporter 8 (ZnT8) is highly expressed in pancreatic beta cells, localizes to insulin secretory granules (ISG), and regulates zinc content. ZnT8 gene…”
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Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION by Liu, Ying, Batchuluun, Battsetseg, Ho, Louisa, Zhu, Dan, Prentice, Kacey J, Bhattacharjee, Alpana, Zhang, Ming, Pourasgari, Farzaneh, Hardy, Alexandre B, Taylor, Kathryn M, Gaisano, Herbert, Dai, Feihan F, Wheeler, Michael B

“…Zinc plays an essential role in the regulation of pancreatic β cell function, affecting important processes including insulin biosynthesis, glucose-stimulated…”
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Progesterone Receptor Membrane Component 1 Is a Functional Part of the Glucagon-like Peptide-1 (GLP-1) Receptor Complex in Pancreatic β Cells by Zhang, Ming, Robitaille, Mélanie, Showalter, Aaron D., Huang, Xinyi, Liu, Ying, Bhattacharjee, Alpana, Willard, Francis S., Han, Junfeng, Froese, Sean, Wei, Li, Gaisano, Herbert Y., Angers, Stéphane, Sloop, Kyle W., Dai, Feihan F., Wheeler, Michael B.

“…Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates glucose homeostasis. Because of their direct stimulation of insulin secretion from…”
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A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells by Dai, Feihan F., Bhattacharjee, Alpana, Liu, Ying, Batchuluun, Battsetseg, Zhang, Ming, Wang, Xinye Serena, Huang, Xinyi, Luu, Lemieux, Zhu, Dan, Gaisano, Herbert, Wheeler, Michael B.

“…GLP1 activates its receptor, GLP1R, to enhance insulin secretion. The activation and transduction of GLP1R requires complex interactions with a host of…”
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Limited Mitochondrial Permeabilization Is an Early Manifestation of Palmitate-induced Lipotoxicity in Pancreatic β-Cells by Koshkin, Vasilij, Dai, Feihan F., Robson-Doucette, Christine A., Chan, Catherine B., Wheeler, Michael B.

“…Involvement of the mitochondrial permeability transition (MPT) pore in early stages of lipotoxic stress in the pancreatic β-cell lines MIN6 and INS-1 was the…”
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Investigation of Transport Mechanisms and Regulation of Intracellular Zn2+ in Pancreatic α-Cells by Gyulkhandanyan, Armen V., Lu, Hongfang, Lee, Simon C., Bhattacharjee, Alpana, Wijesekara, Nadeeja, Fox, Jocelyn E. Manning, MacDonald, Patrick E., Chimienti, Fabrice, Dai, Feihan F., Wheeler, Michael B.

“…During insulin secretion, pancreatic α-cells are exposed to Zn2+ released from insulin-containing secretory granules. Although maintenance of Zn2+ homeostasis…”
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