Search Results - "Dai, Bingbing"

Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis by Kim, Michael P, Li, Xinqun, Deng, Jenying, Zhang, Yun, Dai, Bingbing, Allton, Kendra L, Hughes, Tara G, Siangco, Christian, Augustine, Jithesh J, Kang, Ya'an, McDaniel, Joy M, Xiong, Shunbin, Koay, Eugene J, McAllister, Florencia, Bristow, Christopher A, Heffernan, Timothy P, Maitra, Anirban, Liu, Bin, Barton, Michelle C, Wasylishen, Amanda R, Fleming, Jason B, Lozano, Guillermina

“…Pancreatic ductal adenocarcinoma (PDAC) is almost uniformly fatal and characterized by early metastasis. Oncogenic mutations prevail in 95% of PDAC tumors and…”
Get more information

FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells by Zhang, Yujian, Zhang, Nu, Dai, Bingbing, Liu, Mingguang, Sawaya, Raymond, Xie, Keping, Huang, Suyun

“…We previously found that FoxM1B is overexpressed in human glioblastomas and that forced FoxM1B expression in anaplastic astrocytoma cells leads to the…”
Get full text

Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition by Yan, Liang, Tu, Bo, Yao, Jun, Gong, Jing, Carugo, Alessandro, Bristow, Christopher A, Wang, Qiuyun, Zhu, Cihui, Dai, Bingbing, Kang, Ya'an, Han, Leng, Feng, Ningping, Jin, Yanqing, Fleming, Jason, Heffernan, Timothy P, Yao, Wantong, Ying, Haoqiang

“…Pancreatic ductal adenocarcinoma (PDAC) is almost universally lethal. A critical unmet need exists to explore essential susceptibilities in PDAC and to…”
Get full text

Critical Role and Regulation of Transcription Factor FoxM1 in Human Gastric Cancer Angiogenesis and Progression by Li, Qiang, Zhang, Nu, Jia, Zhiliang, Le, Xiangdong, Dai, Bingbing, Wei, Daoyan, Huang, Suyun, Tan, Dongfeng, Xie, Keping

“…The mammalian forkhead box (Fox) transcription factor FoxM1b is implicated in tumorigenesis. However, the presence of expression and role of FoxM1b in gastric…”
Get full text

Altered Bacterial-Fungal Interkingdom Networks in the Guts of Ankylosing Spondylitis Patients by Li, Ming, Dai, Bingbing, Tang, Yawei, Lei, Lei, Li, Ningning, Liu, Chang, Ge, Teng, Zhang, Lilong, Xu, Yao, Hu, Yuqi, Li, Pengfei, Zhang, Yan, Yuan, Jieli, Li, Xia

“…Intestinal bacterial dysbiosis has been increasingly linked to ankylosing spondylitis (AS), which is a prototypic and best studied subtype of spondyloarthritis…”
Get full text

DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis by Deng, Jenying, Kang, Yaan, Cheng, Chien-Chia, Li, Xinqun, Dai, Bingbing, Katz, Matthew H, Men, Taoyan, Kim, Michael P, Koay, Eugene A, Huang, Huocong, Brekken, Rolf A, Fleming, Jason B

“…Pancreatic ductal adenocarcinoma (PDAC) tumors are characterized by a desmoplastic reaction resulting in dense deposition of collagen that is known to promote…”
Get full text

Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells by Li, Hongyu, Hu, Jing, Wu, Shuhong, Wang, Li, Cao, Xiaobo, Zhang, Xiaoshan, Dai, Bingbing, Cao, Mengru, Shao, Ruping, Zhang, Ran, Majidi, Mourad, Ji, Lin, Heymach, John V, Wang, Michael, Pan, Shiyang, Minna, John, Mehran, Reza J, Swisher, Stephen G, Roth, Jack A, Fang, Bingliang

“…Auranofin, a gold complex that has been used to treat rheumatoid arthritis in clinics and has documented pharmacokinetic and safety profiles in humans, has…”
Get full text

Compound NSC84167 selectively targets NRF2-activated pancreatic cancer by inhibiting asparagine synthesis pathway by Dai, Bingbing, Augustine, Jithesh J., Kang, Ya’an, Roife, David, Li, Xinqun, Deng, Jenying, Tan, Lin, Rusling, Leona A., Weinstein, John N., Lorenzi, Philip L., Kim, Michael P., Fleming, Jason B.

“…Nuclear factor erythroid 2-related factor 2 (NRF2) is aberrantly activated in about 93% of pancreatic cancers. Activated NRF2 regulates multiple downstream…”
Get full text

Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018 by Yang, Juan, Liao, Qiaohong, Luo, Kaiwei, Liu, Fengfeng, Zhou, Yonghong, Zou, Gang, Huang, Wei, Yu, Shuanbao, Wei, Xianglin, Zhou, Jiaxin, Dai, Bingbing, Qiu, Qi, Altmeyer, Ralf, Hu, Hongan, Paireau, Juliette, Luo, Li, Gao, Lidong, Nikolay, Birgit, Hu, Shixiong, Xing, Weijia, Wu, Peng, van Doorn, H. Rogier, Horby, Peter W., Simmonds, Peter, Leung, Gabriel M., Cowling, Benjamin J., Cauchemez, Simon, Yu, Hongjie

“…Enterovirus A71 (EV-A71)–related hand, foot, and mouth disease (HFMD) imposes a substantial clinical burden in the Asia Pacific region. To inform policy on the…”
Get full text

Assessing vaccination coverage, timeliness, and its temporal variations among children in a rural area in China by He, Yangni, Liu, Yang, Dai, Bingbing, Zhao, Liang, Lin, Jiqun, Yang, Juan, Yu, Hongjie

“…China has achieved high vaccination coverage under the Expanded Program on Immunization (EPI) in children 1-2 years of age. However, a knowledge gap exists…”
Get full text

Vaccines delivered by integration-deficient lentiviral vectors targeting dendritic cells induces strong antigen-specific immunity by Hu, Biliang, Dai, Bingbing, Wang, Pin

“…Abstract We report a study of an integration-deficient lentiviral vector (IDLV) enveloped with a Sindbis virus glycoprotein mutant (SVGmu) capable of…”
Get full text

The transfer of maternal antibodies and dynamics of maternal and natural infection-induced antibodies against coxsackievirus A16 in Chinese children 0-13 years of age: a longitudinal cohort study by Zhou, Jiaxin, Zhou, Yonghong, Luo, Kaiwei, Liao, Qiaohong, Zheng, Wen, Gong, Hui, Shi, Huilin, Zhao, Shanlu, Wang, Kai, Qiu, Qi, Dai, Bingbing, Ren, Lingshuang, Wang, Lili, Gao, Lidong, Xu, Meng, Liu, Nuolan, Lu, Wanying, Zheng, Nan, Chen, Xinhua, Chen, Zhiyuan, Yang, Juan, Cauchemez, Simon, Yu, Hongjie

“…A major hand-foot-and-mouth disease (HFMD) pathogen, coxsackievirus A16 (CVA16), has predominated in several of the last 10 years and caused the largest number…”
Get full text

Forkhead Box M1 Is Regulated by Heat Shock Factor 1 and Promotes Glioma Cells Survival under Heat Shock Stress by Dai, Bingbing, Gong, Aihua, Jing, Zhitao, Aldape, Kenneth D., Kang, Shin-Hyuk, Sawaya, Raymond, Huang, Suyun

“…The forkhead box M1 (FoxM1) is a key transcription factor regulating multiple aspects of cell biology. Prior studies have shown that FoxM1 is overexpressed in…”
Get full text

Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo by Meng, Jieru, Dai, Bingbing, Fang, Bingliang, Bekele, B Nebiyou, Bornmann, William G, Sun, Duoli, Peng, Zhenghong, Herbst, Roy S, Papadimitrakopoulou, Vassiliki, Minna, John D, Peyton, Michael, Roth, Jack A

“…AZD6244 and MK2206 are targeted small-molecule drugs that inhibit MEK and AKT respectively. The efficacy of this combination in lung cancer is unknown. Our…”
Get full text

The prognostic value of whole-genome DNA methylation in response to Leflunomide in patients with Rheumatoid Arthritis by Chen, Yulan, Wang, Qiao, Liu, Haina, Jin, Lei, Feng, Xin, Dai, Bingbing, Chen, Meng, Xin, Fangran, Wei, Tingting, Bai, Bingqing, Fan, Zhijun, Li, Jiahui, Yao, Yuxin, Liao, Ruobing, Zhang, Jintao, Jin, Xiangnan, Fu, Lingyu

“…Objective Although Leflunomide (LEF) is effective in treating rheumatoid arthritis (RA), there are still a considerable number of patients who respond poorly…”
Get full text

STAT3 Mediates Resistance to MEK Inhibitor through MicroRNA miR-17 by BINGBING DAI, JIERU MENG, PEYTON, Michael, GIRARD, Luc, BORNMANN, William G, LIN JI, MINNA, John D, BINGLIANG FANG, ROTH, Jack A

“…AZD6244 is a small molecule inhibitor of the MEK (MAP/ERK kinase) pathway currently in clinical trials. However, the mechanisms mediating intrinsic resistance…”
Get full text

KEAP1-Dependent Synthetic Lethality Induced by AKT and TXNRD1 Inhibitors in Lung Cancer by BINGBING DAI, YOO, Suk-Young, BINGLIANG FANG, ROTH, Jack A, BARTHOLOMEUSZ, Geoffrey, GRAHAM, Ryan A, MAJIDI, Mourad, SHAOYU YAN, JIERU MENG, LIN JI, COOMBES, Kevin, MINNA, John D

“…Intrinsic resistance to agents targeting phosphoinositide 3-kinase (PI3K)/AKT pathway is one of the major challenges in cancer treatment with such agents. The…”
Get full text

MicroRNA-124 regulates the radiosensitivity of non-small cell lung cancer cells by targeting TXNRD1 by Hao, Chuncheng, Xu, Xiangying, Ma, Jia, Xia, Jun, Dai, Bingbing, Liu, Lili, Ma, Yuyan

“…Radiation treatment remains one of the major modalities in the treatment of lung cancer. Although the majority of patients initially respond to treatment with…”
Get full text

Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-Targeting Antibody in Pancreatic Ductal Adenocarcinoma by Dai, Bingbing, Roife, David, Kang, Ya'an, Gumin, Joy, Rios Perez, Mayrim V, Li, Xinqun, Pratt, Michael, Brekken, Rolf A, Fueyo-Margareto, Juan, Lang, Frederick F, Fleming, Jason B

“…Delta-24-RGD (DNX-2401) is a conditional replication-competent oncolytic virus engineered to preferentially replicate in and lyse tumor cells with abnormality…”
Get full text

BP1003 Decreases STAT3 Expression and Its Pro-Tumorigenic Functions in Solid Tumors and the Tumor Microenvironment by Gagliardi, Maria, Kean, Rhonda, Dai, Bingbing, Augustine, Jithesh Jose, Roberts, Michael, Fleming, Jason, Hooper, D Craig, Ashizawa, Ana Tari

“…Overexpression and aberrant activation of signal transducer and activator of transcription 3 (STAT3) contribute to tumorigenesis, drug resistance, and…”
Get full text