Search Results - "Dahms, Sven"

ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease by Soh, Wai Tuck, Demir, Fatih, Dall, Elfriede, Perrar, Andreas, Dahms, Sven O, Kuppusamy, Maithreyan, Brandstetter, Hans, Huesgen, Pitter F

“…Bottom-up mass spectrometry-based proteomics utilizes proteolytic enzymes with well characterized specificities to generate peptides amenable for…”
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Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism by Dahms, Sven O., Arciniega, Marcelino, Steinmetzer, Torsten, Huber, Robert, Than, Manuel E.

“…Proprotein convertases (PCs) are highly specific proteases required for the proteolytic modification of many secreted proteins. An unbalanced activity of these…”
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X‑ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket by Dahms, Sven O, Hardes, Kornelia, Steinmetzer, Torsten, Than, Manuel E

“…The proprotein convertase furin is a highly specific serine protease modifying and thereby activating proteins in the secretory pathway by proteolytic…”
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OFF-State-Specific Inhibition of the Proprotein Convertase Furin by Dahms, Sven O, Haider, Tanja, Klebe, Gerhard, Steinmetzer, Torsten, Brandstetter, Hans

“…The pro-protein convertase furin is a highly specific serine protease involved in the proteolytic maturation of many proteins in the secretory pathway. It also…”
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The Effects of Top Management Team National Diversity and Institutional Uncertainty on Subsidiary CSR Focus by Dahms, Sven, Kingkaew, Suthikorn, S. Ng, Eddy

“…This research investigates how top management team national diversity (TMTND) and corporate social responsibility (CSR) institutional uncertainty affect…”
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Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition by Dall, Elfriede, Zauner, Florian B., Soh, Wai Tuck, Demir, Fatih, Dahms, Sven O., Cabrele, Chiara, Huesgen, Pitter F., Brandstetter, Hans

“…The vacuolar cysteine protease legumain plays important functions in seed maturation and plant programmed cell death. Because of their dual protease and ligase…”
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The Peptide Ligase Activity of Human Legumain Depends on Fold Stabilization and Balanced Substrate Affinities by Dall, Elfriede, Stanojlovic, Vesna, Demir, Fatih, Briza, Peter, Dahms, Sven O, Huesgen, Pitter F, Cabrele, Chiara, Brandstetter, Hans

“…Protein modification by enzymatic breaking and forming of peptide bonds significantly expands the repertoire of genetically encoded protein sequences. The dual…”
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Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans by Sabala, Izabela, Jagielska, Elzbieta, Bardelang, Philip T, Czapinska, Honorata, Dahms, Sven O, Sharpe, Jason A, James, Richard, Than, Manuel E, Thomas, Neil R, Bochtler, Matthias

“…Staphylococcus simulans biovar staphylolyticus lysostaphin efficiently cleaves Staphylococcus aureus cell walls. The protein is in late clinical trials as a…”
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Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor by Dahms, Sven O, Jiao, Guan-Sheng, Than, Manuel E

“…Proprotein convertases (PCs) represent highly selective serine proteases that activate their substrates upon proteolytic cleavage. Their inhibition is a…”
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Synergy between multidimensional intellectual capital and digital knowledge management: Uncovering innovation performance complexities by Cabrilo, Sladjana, Dahms, Sven, Tsai, Fu-Sheng

“…This paper aims to deepen our understanding of the contingency and complex interrelations between multidimensional intellectual capital (IC), technology-based…”
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The Amyloid Precursor Protein Shows a pH-Dependent Conformational Switch in Its E1 Domain by Hoefgen, Sandra, Dahms, Sven O., Oertwig, Kathrin, Than, Manuel E.

“…The amyloid precursor protein (APP) and its proteolytic cleavage product Aβ are widely believed to be central to the etiology of Alzheimer's disease (AD). APP…”
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Legumain Functions as a Transient TrkB Sheddase by Holzner, Christoph, Böttinger, Katharina, Blöchl, Constantin, Huber, Christian G, Dahms, Sven O, Dall, Elfriede, Brandstetter, Hans

“…While primarily found in endo-lysosomal compartments, the cysteine protease legumain can also translocate to the cell surface if stabilized by the interaction…”
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Sirtilins – the new old members of the vitamin K‐dependent coagulation factor family by Dahms, Sven O., Demir, Fatih, Huesgen, Pitter F., Thorn, Karina, Brandstetter, Hans

“…Essentials Blood coagulation is driven by vitamin K (VK)‐dependent proteases. We have identified and characterized ‘sirtilin’ as an additional VK‐dependent…”
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Analysis of the overall structure of the multi-domain amyloid precursor protein (APP) by Coburger, Ina, Dahms, Sven O, Roeser, Dirk, Gührs, Karl-Heinz, Hortschansky, Peter, Than, Manuel E

“…The amyloid precursor protein (APP) and its processing by the α-, β- and γ-secretases is widely believed to play a central role during the development of…”
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Emerging Market Multinational Family Business Groups and the Use of Family Managers in Foreign Subsidiaries by Chung, Hsi-Mei, Dahms, Sven, Kao, Pao T.

“…Little is known about the internationalization behavior of Emerging Market Family Business Groups (EFBGs) and their strategic usage of family managers in…”
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Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states by Dall, Elfriede, Hollerweger, Julia C., Dahms, Sven O., Cui, Haissi, Häussermann, Katharina, Brandstetter, Hans

“…Protein activity is often regulated by altering the oligomerization state. One mechanism of multimerization involves domain swapping, wherein proteins exchange…”
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X‑ray Structures of Human Furin in Complex with Competitive Inhibitors by Dahms, Sven O, Hardes, Kornelia, Becker, Gero L, Steinmetzer, Torsten, Brandstetter, Hans, Than, Manuel E

“…Furin inhibitors are promising therapeutics for the treatment of cancer and numerous infections caused by bacteria and viruses, including the highly lethal…”
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Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain by Dahms, Sven O., Könnig, Ina, Roeser, Dirk, Gührs, Karl-Heinz, Mayer, Magnus C., Kaden, Daniela, Multhaup, Gerd, Than, Manuel E.

“…The amyloid precursor protein (APP) and its neurotoxic cleavage product Aβ are key players in the development of Alzheimer's disease and appear essential for…”
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Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors by Lange, Roman W, Bloch, Konstantin, Heindl, Miriam Ruth, Wollenhaupt, Jan, Weiss, Manfred S, Brandstetter, Hans, Klebe, Gerhard, Falcone, Franco H, Böttcher-Friebertshäuser, Eva, Dahms, Sven O, Steinmetzer, Torsten

“…A 1H-isoindol-3-amine was identified as suitable P1 group for the proprotein convertase furin using a crystallographic screening with a set of 20 fragments…”
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Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein by Dahms, Sven O, Hoefgen, Sandra, Roeser, Dirk, Schlott, Bernhard, Gührs, Karl-Heinz, Than, Manuel E

“…The amyloid precursor protein (APP) is the key player in Alzheimer's disease pathology, yet APP and its analogues are also essential for neuronal development…”
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