Search Results - "Dahmane, Nadia"

In Vivo Detection of EGFRvIII in Glioblastoma via Perfusion Magnetic Resonance Imaging Signature Consistent with Deep Peritumoral Infiltration: The φ -Index by Bakas, Spyridon, Akbari, Hamed, Pisapia, Jared, Martinez-Lage, Maria, Rozycki, Martin, Rathore, Saima, Dahmane, Nadia, O'Rourke, Donald M, Davatzikos, Christos

“…The epidermal growth factor receptor variant III ( ) mutation has been considered a driver mutation and therapeutic target in glioblastoma, the most common and…”
Get full text

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α by Wang, Qirui, He, Zhenqiang, Huang, Menggui, Liu, Tianrun, Wang, Yanling, Xu, Haineng, Duan, Hao, Ma, Peihong, Zhang, Lin, Zamvil, Scott S., Hidalgo, Juan, Zhang, Zhenfeng, O’Rourke, Donald M., Dahmane, Nadia, Brem, Steven, Mou, Yonggao, Gong, Yanqing, Fan, Yi

“…Spatiotemporal regulation of tumor immunity remains largely unexplored. Here we identify a vascular niche that controls alternative macrophage activation in…”
Get full text

Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques by Macyszyn, Luke, Akbari, Hamed, Pisapia, Jared M, Da, Xiao, Attiah, Mark, Pigrish, Vadim, Bi, Yingtao, Pal, Sharmistha, Davuluri, Ramana V, Roccograndi, Laura, Dahmane, Nadia, Martinez-Lage, Maria, Biros, George, Wolf, Ronald L, Bilello, Michel, O'Rourke, Donald M, Davatzikos, Christos

“…MRI characteristics of brain gliomas have been used to predict clinical outcome and molecular tumor characteristics. However, previously reported imaging…”
Get full text

Immune landscapes associated with different glioblastoma molecular subtypes by Martinez-Lage, Maria, Lynch, Timothy M, Bi, Yingtao, Cocito, Carolina, Way, Gregory P, Pal, Sharmistha, Haller, Josephine, Yan, Rachel E, Ziober, Amy, Nguyen, Aivi, Kandpal, Manoj, O'Rourke, Donald M, Greenfield, Jeffrey P, Greene, Casey S, Davuluri, Ramana V, Dahmane, Nadia

“…Recent work has highlighted the tumor microenvironment as a central player in cancer. In particular, interactions between tumor and immune cells may help drive…”
Get full text

c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma by Huang, Menggui, Liu, Tianrun, Ma, Peihong, Mitteer, Jr, R Alan, Zhang, Zhenting, Kim, Hyun Jun, Yeo, Eujin, Zhang, Duo, Cai, Peiqiang, Li, Chunsheng, Zhang, Lin, Zhao, Botao, Roccograndi, Laura, O'Rourke, Donald M, Dahmane, Nadia, Gong, Yanqing, Koumenis, Constantinos, Fan, Yi

“…Aberrant vascularization is a hallmark of cancer progression and treatment resistance. Here, we have shown that endothelial cell (EC) plasticity drives…”
Get full text

Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons by Wapinski, Orly L., Lee, Qian Yi, Chen, Albert C., Li, Rui, Corces, M. Ryan, Ang, Cheen Euong, Treutlein, Barbara, Xiang, Chaomei, Baubet, Valérie, Suchy, Fabian Patrik, Sankar, Venkat, Sim, Sopheak, Quake, Stephen R., Dahmane, Nadia, Wernig, Marius, Chang, Howard Y.

“…How transcription factors (TFs) reprogram one cell lineage to another remains unclear. Here, we define chromatin accessibility changes induced by the proneural…”
Get full text

Alternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development by Pal, Sharmistha, Gupta, Ravi, Kim, Hyunsoo, Wickramasinghe, Priyankara, Baubet, Valérie, Showe, Louise C, Dahmane, Nadia, Davuluri, Ramana V

“…Despite our growing knowledge that many mammalian genes generate multiple transcript variants that may encode functionally distinct protein isoforms, the…”
Get full text

Leptomeningeal dissemination in pediatric brain tumors by Cocito, Carolina, Martin, Brice, Giantini-Larsen, Alexandra M., Valcarce-Aspegren, Marcus, Souweidane, Mark M., Szalontay, Luca, Dahmane, Nadia, Greenfield, Jeffrey P.

“…Leptomeningeal disease (LMD) in pediatric brain tumors (PBTs) is a poorly understood and categorized phenomenon. LMD incidence rates, as well as diagnosis,…”
Get full text

Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes by Wang, Zhuo, Deng, Zhong, Dahmane, Nadia, Tsai, Kevin, Wang, Pu, Williams, Dewight R., Kossenkov, Andrew V., Showe, Louise C., Zhang, Rugang, Huang, Qihong, Conejo-Garcia, José R., Lieberman, Paul M.

“…Telomeric repeat-containing RNA (TERRA) has been identified as a telomere-associated regulator of chromosome end protection. Here, we report that TERRA can…”
Get full text

Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened by BIN LI, LIANG FEI, Dennis, ORTON, Darren, LU HAN, BAOLIN WANG, CAPOBIANCO, Anthony J, ETHAN LEE, ROBBINS, David J, FLAVENY, Colin A, DAHMANE, Nadia, BAUBET, Valérie, ZHIQIANG WANG, FENG BAI, PEI, Xin-Hai, RODRIGUEZ-BIANCO, Jezabel, BRIAN HANG

“…The Hedgehog (HH) signaling pathway represents an important class of emerging developmental signaling pathways that play critical roles in the genesis of a…”
Get full text

B7–H3 as a Prognostic Biomarker and Therapeutic Target in Pediatric central nervous system Tumors by Maachani, Uday B., Tosi, Umberto, Pisapia, David J., Mukherjee, Sushmita, Marnell, Christopher S., Voronina, Julia, Martinez, Daniel, Santi, Mariarita, Dahmane, Nadia, Zhou, Zhiping, Hawkins, Cynthia, Souweidane, Mark M.

“…B7–H3 (CD276), a member of the B7 superfamily, is an important factor in downregulating immune responses against tumors. It is also aberrantly expressed in…”
Get full text

Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas by Yin, Yibo, Boesteanu, Alina C., Binder, Zev A., Xu, Chong, Reid, Reiss A., Rodriguez, Jesse L., Cook, Danielle R., Thokala, Radhika, Blouch, Kristin, McGettigan-Croce, Bevin, Zhang, Logan, Konradt, Christoph, Cogdill, Alexandria P., Panjwani, M. Kazim, Jiang, Shuguang, Migliorini, Denis, Dahmane, Nadia, Posey, Avery D., June, Carl H., Mason, Nicola J., Lin, Zhiguo, O’Rourke, Donald M., Johnson, Laura A.

“…We generated two humanized interleukin-13 receptor α2 (IL-13Rα2) chimeric antigen receptors (CARs), Hu07BBz and Hu08BBz, that recognized human IL-13Rα2, but…”
Get full text

Sonic hedgehog controls stem cell behavior in the postnatal and adult brain by Palma, Verónica, Lim, Daniel A, Dahmane, Nadia, Sánchez, Pilar, Brionne, Thomas C, Herzberg, Claudia D, Gitton, Yorick, Carleton, Alan, Alvarez-Buylla, Arturo, Ruiz i Altaba, Ariel

“…Sonic hedgehog (Shh) signaling controls many aspects of ontogeny, orchestrating congruent growth and patterning. During brain development, Shh regulates early…”
Get full text

Sonic hedgehog regulates the growth and patterning of the cerebellum by Dahmane, N, Ruiz i Altaba, A

“…The molecular bases of brain development and CNS malignancies remain poorly understood. Here we show that Sonic hedgehog (Shh) signaling controls the…”
Get full text

Rp58 is essential for the growth and patterning of the cerebellum and for glutamatergic and GABAergic neuron development by Baubet, Valérie, Xiang, Chaomei, Molczan, Aliah, Roccograndi, Laura, Melamed, Svetlana, Dahmane, Nadia

“…Cerebellum development depends on the correct differentiation of progenitors into neurons, a process controlled by a transcriptional program that remains…”
Get full text

Transcriptome signatures associated with meningioma progression by Viaene, Angela N, Zhang, Bo, Martinez-Lage, Maria, Xiang, Chaomei, Tosi, Umberto, Thawani, Jayesh P, Gungor, Busra, Zhu, Yuankun, Roccograndi, Laura, Zhang, Logan, Bailey, Robert L, Storm, Phillip B, O'Rourke, Donald M, Resnick, Adam C, Grady, M Sean, Dahmane, Nadia

“…Meningiomas are the most common primary brain tumor of adults. The majority are benign (WHO grade I), with a mostly indolent course; 20% of them (WHO grade II…”
Get full text

The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis by Dahmane, N, Sánchez, P, Gitton, Y, Palma, V, Sun, T, Beyna, M, Weiner, H, Ruiz i Altaba, A

“…The mechanisms that regulate the growth of the brain remain unclear. We show that Sonic hedgehog ( Shh ) is expressed in a layer-specific manner in the…”
Get full text

ZNF238 Is Expressed in Postmitotic Brain Cells and Inhibits Brain Tumor Growth by TATARD, Valérie M, CHAOMEI XIANG, BIEGEL, Jaclyn A, DAHMANE, Nadia

“…Brain tumors such as medulloblastoma (MB) and glioblastoma multiforme (GBM) can derive from neural precursors. For instance, many MBs are thought to arise from…”
Get full text

Design and Synthesis of Inhibitors of Hedgehog Signaling Based on the Alkaloid Cyclopamine by Winkler, Jeffrey D, Isaacs, André, Holderbaum, Laura, Tatard, Valérie, Dahmane, Nadia

“…The synthesis and biological evaluation of structurally simplified, metabolically stable cyclopamine-like Sonic Hedgehog (SHH) signaling inhibitors, i.e., 5,…”
Get full text

Multivariate Analysis of Preoperative Magnetic Resonance Imaging Reveals Transcriptomic Classification of de novo Glioblastoma Patients by Rathore, Saima, Akbari, Hamed, Bakas, Spyridon, Pisapia, Jared M, Shukla, Gaurav, Rudie, Jeffrey D, Da, Xiao, Davuluri, Ramana V, Dahmane, Nadia, O'Rourke, Donald M, Davatzikos, Christos

“…Glioblastoma, the most frequent primary malignant brain neoplasm, is genetically diverse and classified into four transcriptomic subtypes, i. e., classical,…”
Get full text