Search Results - "Dahlstrom, E"

Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer by Boulding, Tara, Wu, Fan, McCuaig, Robert, Dunn, Jennifer, Sutton, Christopher R, Hardy, Kristine, Tu, Wenjuan, Bullman, Amanda, Yip, Desmond, Dahlstrom, Jane E, Rao, Sudha

“…Dual-specificity phosphatases (DUSPs) dephosphorylate threonine/serine and tyrosine residues on their substrates. Here we show that DUSP1, DUSP4, and DUSP6 are…”
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Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia by Hu, Mingjing, Eviston, David, Hsu, Peter, Mariño, Eliana, Chidgey, Ann, Santner-Nanan, Brigitte, Wong, Kahlia, Richards, James L., Yap, Yu Anne, Collier, Fiona, Quinton, Ann, Joung, Steven, Peek, Michael, Benzie, Ron, Macia, Laurence, Wilson, David, Ponsonby, Ann-Louise, Tang, Mimi L. K., O’Hely, Martin, Daly, Norelle L., Mackay, Charles R., Dahlstrom, Jane E., Vuillermin, Peter, Nanan, Ralph

“…Maternal immune dysregulation seems to affect fetal or postnatal immune development. Preeclampsia is a pregnancy-associated disorder with an immune basis and…”
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Accelerated Maturation and Abnormal Morphology in the Preterm Neonatal Kidney by SUTHERLAND, Megan R, GUBHAJU, Lina, MOORE, Lynette, KENT, Alison L, DAHLSTROM, Jane E, HORNE, Rosemary S. C, HOY, Wendy E, BERTRAM, John F, BLACK, M. Jane

“…Nephrogenesis is ongoing at the time of birth for the majority of preterm infants, but whether postnatal renal development follows a similar trajectory to…”
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The Bonar score revisited: Region of evaluation significantly influences the standardized assessment of tendon degeneration by Fearon, Angela, Dahlstrom, Jane E, Twin, Jane, Cook, Jill, Scott, Alex

“…Abstract Objectives Tendinopathy is a common, costly condition affecting both sporting and sedentary populations. Research into tendinopathy frequently…”
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Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes by Dooley, James, Tian, Lei, Schonefeldt, Susann, Delghingaro-Augusto, Viviane, Garcia-Perez, Josselyn E, Pasciuto, Emanuela, Di Marino, Daniele, Carr, Edward J, Oskolkov, Nikolay, Lyssenko, Valeriya, Franckaert, Dean, Lagou, Vasiliki, Overbergh, Lut, Vandenbussche, Jonathan, Allemeersch, Joke, Chabot-Roy, Genevieve, Dahlstrom, Jane E, Laybutt, D Ross, Petrovsky, Nikolai, Socha, Luis, Gevaert, Kris, Jetten, Anton M, Lambrechts, Diether, Linterman, Michelle A, Goodnow, Chris C, Nolan, Christopher J, Lesage, Sylvie, Schlenner, Susan M, Liston, Adrian

“…Adrian Liston and colleagues use a transgenic mouse model to demonstrate that beta cell failure is a mechanistic commonality in type 1 and type 2 diabetes…”
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Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation by Hughes, Mark M., Hooftman, Alexander, Angiari, Stefano, Tummala, Padmaja, Zaslona, Zbigniew, Runtsch, Marah C., McGettrick, Anne F., Sutton, Caroline E., Diskin, Ciana, Rooke, Melissa, Takahashi, Shuhei, Sundararaj, Srinivasan, Casarotto, Marco G., Dahlstrom, Jane E., Palsson-McDermott, Eva M., Corr, Sinead C., Mills, Kingston H.G., Preston, Roger J.S., Neamati, Nouri, Xie, Yiyue, Baell, Jonathan B., Board, Philip G., O’Neill, Luke A.J.

“…The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the…”
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Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo by Sun, Ramon C, Fadia, Mitali, Dahlstrom, Jane E, Parish, Christopher R, Board, Philip G, Blackburn, Anneke C

“…The glycolytic phenotype is a widespread phenomenon in solid cancer forms, including breast cancer. Dichloroacetate (DCA) has recently been proposed as a novel…”
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Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer Properties by Galgamuwa, Ramindhu, Hardy, Kristine, Dahlstrom, Jane E, Blackburn, Anneke C, Wium, Elize, Rooke, Melissa, Cappello, Jean Y, Tummala, Padmaja, Patel, Hardip R, Chuah, Aaron, Tian, Luyang, McMorrow, Linda, Board, Philip G, Theodoratos, Angelo

“…Cisplatin is an effective anticancer drug; however, cisplatin use often leads to nephrotoxicity, which limits its clinical effectiveness. In this study, we…”
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Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch by Tu, Wen Juan, McCuaig, Robert D, Tan, Abel H Y, Hardy, Kristine, Seddiki, Nabila, Ali, Sayed, Dahlstrom, Jane E, Bean, Elaine G, Dunn, Jenny, Forwood, Jade, Tsimbalyuk, Sofia, Smith, Kate, Yip, Desmond, Malik, Laeeq, Prasanna, Thiru, Milburn, Peter, Rao, Sudha

“…Lysine specific demethylase 1 (LSD1) is a key epigenetic eraser enzyme implicated in cancer metastases and recurrence. Nuclear LSD1 phosphorylated at serine…”
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Recurrence in early breast cancer: Analysis of data from 3,765 Australian women treated between 1997 and 2015 by Stuart-Harris, Robin, Dahlstrom, Jane E., Gupta, Ruta, Zhang, Yanping, Craft, Paul, Shadbolt, Bruce

“…Evidence suggests recent improvements in outcome in early breast cancer (EBC). To analyse recurrence in women with EBC from our region from 1997 to 2015. We…”
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H2A.B is a cancer/testis factor involved in the activation of ribosome biogenesis in Hodgkin lymphoma by Jiang, Xuanzhao, Wen, Jiayu, Paver, Elizabeth, Wu, Yu-Huan, Sun, Gege, Bullman, Amanda, Dahlstrom, Jane E, Tremethick, David J, Soboleva, Tatiana A

“…Testis-specific regulators of chromatin function are commonly ectopically expressed in human cancers, but their roles are poorly understood. Examination of 81…”
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Naturally occurring endo-siRNA silences LINE-1 retrotransposons in human cells through DNA methylation by Chen, Long, Dahlstrom, Jane E., Lee, Sung-Hun, Rangasamy, Danny

“…Long interspersed nuclear element 1 (LINE-1) retrotransposons are mutagens that are capable of generating deleterious mutations by inserting themselves into…”
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Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants by Ryan, Danica, Sutherland, Megan R., Flores, Tracey J., Kent, Alison L., Dahlstrom, Jane E., Puelles, Victor G., Bertram, John F., McMahon, Andrew P., Little, Melissa H., Moore, Lynette, Black, Mary Jane

“…During normal human kidney development, nephrogenesis (the formation of nephrons) is complete by term birth, with the majority of nephrons formed late in…”
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Helping mentors address scientific communication in STEM research training helps their mentees stay the course by Cameron, C., Lee, H. Y., Anderson, C. B., Dahlstrom, E. K., Chang, S.

“…Background Scientific communication (SC) has important social-cognitive, behavioral, and career-related benefits for emerging researchers, but both mentors and…”
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Molecular patterns in salivary duct carcinoma identify prognostic subgroups by Mueller, Simon A., Gauthier, Marie-Emilie A., Blackburn, James, Grady, John P., Kraitsek, Spiridoula, Hajdu, Elektra, Dettmer, Matthias S., Dahlstrom, Jane E., Lee, C. Soon, Luk, Peter P., Yu, Bing, Giger, Roland, Kummerfeld, Sarah, Clark, Jonathan R., Gupta, Ruta, Cowley, Mark J.

“…Salivary duct carcinoma (SDCa) is a rare cancer with high rate of metastases and poor survival despite aggressive multimodality treatment. This study analyzes…”
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GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity by Menon, Deepthi, Innes, Ashlee, Oakley, Aaron J., Dahlstrom, Jane E., Jensen, Lora M., Brüstle, Anne, Tummala, Padmaja, Rooke, Melissa, Casarotto, Marco G., Baell, Jonathan B., Nguyen, Nghi, Xie, Yiyue, Cuellar, Matthew, Strasser, Jessica, Dahlin, Jayme L., Walters, Michael A., Burgio, Gaetan, O’Neill, Luke A. J., Board, Philip G.

“…Glutathione transferase Omega 1 (GSTO1-1) is an atypical GST reported to play a pro-inflammatory role in response to LPS. Here we show that genetic knockout of…”
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Nuclear-Biased DUSP6 Expression is Associated with Cancer Spreading Including Brain Metastasis in Triple-Negative Breast Cancer by Wu, Fan, McCuaig, Robert D, Sutton, Christopher R, Tan, Abel H Y, Jeelall, Yoshni, Bean, Elaine G, Dai, Jin, Prasanna, Thiru, Batham, Jacob, Malik, Laeeq, Yip, Desmond, Dahlstrom, Jane E, Rao, Sudha

“…DUSP6 is a dual-specificity phosphatase (DUSP) involved in breast cancer progression, recurrence, and metastasis. DUSP6 is predominantly cytoplasmic in HER2+…”
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Inhibition of LINE-1 retrotransposon-encoded reverse transcriptase modulates the expression of cell differentiation genes in breast cancer cells by Patnala, Radhika, Lee, Sung-Hun, Dahlstrom, Jane E., Ohms, Stephen, Chen, Long, Dheen, S. Thameem, Rangasamy, Danny

“…Long Interspersed Elements (L1 elements) are biologically active retrotransposons that are capable of autonomous replication using their own reverse…”
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A Phase 1 Proof of Concept Study Evaluating the Addition of an LSD1 Inhibitor to Nab-Paclitaxel in Advanced or Metastatic Breast Cancer (EPI-PRIMED) by Prasanna, Thiru, Malik, Laeeq, McCuaig, Robert D., Tu, Wen Juan, Wu, Fan, Lim, Pek Siew, Tan, Abel H. Y., Dahlstrom, Jane E., Clingan, Philip, Moylan, Eugene, Chrisp, Jeremy, Fuller, David, Rao, Sudha, Yip, Desmond

“…ObjectiveLysine-Specific Demethylase-1 (LSD1) is overexpressed in breast cancer cells and facilitate mesenchymal properties which may contribute to therapeutic…”
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When birth comes early: Effects on nephrogenesis by Black, Mary Jane, Sutherland, Megan R, Gubhaju, Lina, Kent, Alison L, Dahlstrom, Jane E, Moore, Lynette

“…Preterm birth (birth prior to 37 completed weeks of gestation) may occur at a time when the infant kidney is very immature and nephrogenesis is often ongoing…”
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