Search Results - "Dahlem, Charlotte"

The Insulin-Like Growth Factor 2 mRNA Binding Protein IMP2/IGF2BP2 is Overexpressed and Correlates with Poor Survival in Pancreatic Cancer by Dahlem, Charlotte, Barghash, Ahmad, Puchas, Philip, Haybaeck, Johannes, Kessler, Sonja M

“…The insulin-like growth factor 2 ( ) mRNA binding protein IMP2 (IGF2BP2) is an oncogenic protein known to be overexpressed in different tumor types. Pancreatic…”
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Toll-Like Receptor 2 Release by Macrophages: An Anti-inflammatory Program Induced by Glucocorticoids and Lipopolysaccharide by Hoppstädter, Jessica, Dembek, Anna, Linnenberger, Rebecca, Dahlem, Charlotte, Barghash, Ahmad, Fecher-Trost, Claudia, Fuhrmann, Gregor, Koch, Marcus, Kraegeloh, Annette, Huwer, Hanno, Kiemer, Alexandra K

“…Glucocorticoids (GCs) are widely prescribed therapeutics for the treatment of inflammatory diseases, and endogenous GCs play a key role in immune regulation…”
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Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism by Park, Yu Mi, Dahlem, Charlotte, Meyer, Markus R, Kiemer, Alexandra K, Müller, Rolf, Herrmann, Jennifer

“…Zebrafish (ZF; ) larvae have become a popular in vivo model in drug metabolism studies. Here, we investigated the metabolism of methyl 2-[1-(4-fluorobutyl)-1…”
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Dysregulation of cholesterol homeostasis in human lung cancer tissue and tumour-associated macrophages by Hoppstädter, Jessica, Dembek, Anna, Höring, Marcus, Schymik, Hanna S., Dahlem, Charlotte, Sultan, Afnan, Wirth, Natalie, Al-Fityan, Salma, Diesel, Britta, Gasparoni, Gilles, Walter, Jörn, Helms, Volkhard, Huwer, Hanno, Simon, Martin, Liebisch, Gerhard, Schulz, Marcel H., Kiemer, Alexandra K.

“…Based on reports on elevated cholesterol levels in cancer cells, strategies to lower cholesterol synthesis have been suggested as an antitumour strategy…”
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Characterization of Anti-Cancer Activities of Violacein: Actions on Tumor Cells and the Tumor Microenvironment by Dahlem, Charlotte, Chanda, Shilpee, Hemmer, Jan, Schymik, Hanna S, Kohlstedt, Michael, Wittmann, Christoph, Kiemer, Alexandra K

“…Natural products have been shown to serve as promising starting points for novel anti-cancer drugs. In this study, the anti-cancer activities of the purple…”
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Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections by Goes, Adriely, Lapuhs, Philipp, Kuhn, Thomas, Schulz, Eilien, Richter, Robert, Panter, Fabian, Dahlem, Charlotte, Koch, Marcus, Garcia, Ronald, Kiemer, Alexandra K, Müller, Rolf, Fuhrmann, Gregor

“…In 2019, it was estimated that 2.5 million people die from lower tract respiratory infections annually. One of the main causes of these infections is , a…”
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Gene Editing and Small Molecule Inhibitors of the RNA Binding Protein IGF2BP2/IMP2 Show its Potential as an Anti-Cancer Drug Target by Chanda, Shilpee, Lepikhov, Konstantin, Dahlem, Charlotte, Schymik, Hanna S, Hoppstädter, Jessica, Geber, An-Kristin, Wagner, Konrad, Kessler, Sonja M, Empting, Martin, Kiemer, Alexandra K

“…The RNA-binding protein IGF2BP2/IMP2/VICKZ2/p62 is an oncofetal protein that is overexpressed in several cancer entities. Employing IMP2 knockout colorectal…”
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Baikalomycins A-C, New Aquayamycin-Type Angucyclines Isolated from Lake Baikal Derived Streptomyces sp. IB201691-2A by Voitsekhovskaia, Irina, Paulus, Constanze, Dahlem, Charlotte, Rebets, Yuriy, Nadmid, Suvd, Zapp, Josef, Axenov-Gribanov, Denis, Rückert, Christian, Timofeyev, Maxim, Kalinowski, Jörn, Kiemer, Alexandra K, Luzhetskyy, Andriy

“…Natural products produced by bacteria found in unusual and poorly studied ecosystems, such as Lake Baikal, represent a promising source of new valuable drug…”
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Development of a Streptomyces-based system for facile thioholgamide library generation and analysis by Lopatniuk, Maria, Riedel, Florian, Wildfeuer, Julia, Stierhof, Marc, Dahlem, Charlotte, Kiemer, Alexandra K., Luzhetskyy, Andriy

“…Derivatizing natural products (NPs) is essential in structure-activity relationship (SAR) studies, compound optimization, and drug development. Ribosomally…”
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First Small-Molecule Inhibitors Targeting the RNA-Binding Protein IGF2BP2/IMP2 for Cancer Therapy by Dahlem, Charlotte, Abuhaliema, Ali, Kessler, Sonja M, Kröhler, Tarek, Zoller, Ben G. E, Chanda, Shilpee, Wu, Yingwen, Both, Simon, Müller, Fabian, Lepikhov, Konstantin, Kirsch, Susanne H, Laggai, Stephan, Müller, Rolf, Empting, Martin, Kiemer, Alexandra K

“…The RNA-binding protein IGF2BP2/IMP2/VICKZ2/p62 is overexpressed in several tumor entities, promotes tumorigenesis and tumor progression, and has been…”
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Comment on: The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ by Schymik, Hanna S., Dahlem, Charlotte, Barghash, Ahmad, Kiemer, Alexandra K.

“…Recently, first insights into the regulation and the role of the RNA‐binding protein IMP2 in macrophage activation have been published by Wang et al. This…”
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Targeted delivery of functionalized PLGA nanoparticles to macrophages by complexation with the yeast Saccharomyces cerevisiae by Kiefer, Ruth, Jurisic, Marijas, Dahlem, Charlotte, Koch, Marcus, Schmitt, Manfred J., Kiemer, Alexandra K., Schneider, Marc, Breinig, Frank

“…Nanoparticles (NPs) are able to deliver a variety of substances into eukaryotic cells. However, their usage is often hampered by a lack of specificity, leading…”
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Perquinolines A–C: Unprecedented Bacterial Tetrahydroisoquinolines Involving an Intriguing Biosynthesis by Rebets, Yuriy, Nadmid, Suvd, Paulus, Constanze, Dahlem, Charlotte, Herrmann, Jennifer, Hübner, Harald, Rückert, Christian, Kiemer, Alexandra K., Gmeiner, Peter, Kalinowski, Jörn, Müller, Rolf, Luzhetskyy, Andriy

“…Metabolic profiling of Streptomyces sp. IB2014/016‐6 led to the identification of three new tetrahydroisoquinoline natural products, perquinolines A–C (1–3)…”
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Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA by Fathalla, Reem K., Fröhner, Wolfgang, Bader, Chantal D., Fischer, Patrick D., Dahlem, Charlotte, Chatterjee, Deep, Mathea, Sebastian, Kiemer, Alexandra K., Arthanari, Haribabu, Müller, Rolf, Abdel-Halim, Mohammad, Ducho, Christian, Engel, Matthias

“…To develop novel antibiotics, targeting the early steps of cell wall peptidoglycan biosynthesis seems to be a promising strategy that is still underutilized…”
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The glucocorticoid‐induced leucine zipper mediates statin‐induced muscle damage by Hoppstädter, Jessica, Valbuena Perez, Jenny Vanessa, Linnenberger, Rebecca, Dahlem, Charlotte, Legroux, Thierry M., Hecksteden, Anne, Tse, William K. F., Flamini, Sara, Andreas, Anastasia, Herrmann, Jennifer, Herr, Christian, Müller, Rolf, Meyer, Tim, Bals, Robert, Riccardi, Carlo, Bruscoli, Stefano, Kiemer, Alexandra K.

“…Statins, the most prescribed class of drugs for the treatment of hypercholesterolemia, can cause muscle‐related adverse effects. It has been shown that the…”
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Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism by Dahlem, Charlotte, Siow, Wei Xiong, Lopatniuk, Maria, Tse, William K F, Kessler, Sonja M, Kirsch, Susanne H, Hoppstädter, Jessica, Vollmar, Angelika M, Müller, Rolf, Luzhetskyy, Andriy, Bartel, Karin, Kiemer, Alexandra K

“…Natural products represent powerful tools searching for novel anticancer drugs. Thioholgamide A (thioA) is a ribosomally synthesized and post-translationally…”
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Perquinoline A–C: neuartige bakterielle Tetrahydroisochinoline mit einer bemerkenswerten Biosynthese by Rebets, Yuriy, Nadmid, Suvd, Paulus, Constanze, Dahlem, Charlotte, Herrmann, Jennifer, Hübner, Harald, Rückert, Christian, Kiemer, Alexandra K., Gmeiner, Peter, Kalinowski, Jörn, Müller, Rolf, Luzhetskyy, Andriy

“…Abstract Die Analyse des metabolischen Profils von Streptomyces sp. IB2014/ 016‐6 führte zur Identifizierung der drei neuen Tetrahydroisochinolin‐Naturstoffe…”
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Perquinoline A–C: neuartige bakterielle Tetrahydroisochinoline mit einer bemerkenswerten Biosynthese by Rebets, Yuriy, Nadmid, Suvd, Paulus, Constanze, Dahlem, Charlotte, Herrmann, Jennifer, Hübner, Harald, Rückert, Christian, Kiemer, Alexandra K., Gmeiner, Peter, Kalinowski, Jörn, Müller, Rolf, Luzhetskyy, Andriy

“…Die Analyse des metabolischen Profils von Streptomyces sp. IB2014/ 016‐6 führte zur Identifizierung der drei neuen Tetrahydroisochinolin‐Naturstoffe…”
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