Search Results - "Dahlén, Anders"

Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale by Paramasivam, Prasath, Franke, Christian, Stöter, Martin, Höijer, Andreas, Bartesaghi, Stefano, Sabirsh, Alan, Lindfors, Lennart, Arteta, Marianna Yanez, Dahlén, Anders, Bak, Annette, Andersson, Shalini, Kalaidzidis, Yannis, Bickle, Marc, Zerial, Marino

“…Delivery of exogenous mRNA using lipid nanoparticles (LNPs) is a promising strategy for therapeutics. However, a bottleneck remains in the poor understanding…”
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In Vivo Metabolite Profiles of an N -Acetylgalactosamine–Conjugated Antisense Oligonucleotide AZD8233 Using Liquid Chromatography High-Resolution Mass Spectrometry: A Cross-Species Comparison in Animals and Humans by Li, Xue-Qing, Elebring, Marie, Dahlén, Anders, Weidolf, Lars

“…AZD8233, a liver-targeting antisense oligonucleotide (ASO), inhibits subtilisin/kexin type 9 protein synthesis. It is a phosphorothioated 3-10-3 gapmer with a…”
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Stealth Fluorescence Labeling for Live Microscopy Imaging of mRNA Delivery by Baladi, Tom, Nilsson, Jesper R, Gallud, Audrey, Celauro, Emanuele, Gasse, Cécile, Levi-Acobas, Fabienne, Sarac, Ivo, Hollenstein, Marcel R, Dahlén, Anders, Esbjörner, Elin K, Wilhelmsson, L. Marcus

“…Methods for tracking RNA inside living cells without perturbing their natural interactions and functions are critical within biology and, in particular, to…”
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Intracellular Absolute Quantification of Oligonucleotide Therapeutics by NanoSIMS by Becquart, Cécile, Stulz, Rouven, Thomen, Aurélien, Dost, Maryam, Najafinobar, Neda, Dahlén, Anders, Andersson, Shalini, Ewing, Andrew G., Kurczy, Michael E.

“…Antisense oligonucleotide (ASO)-based therapeutics hold great potential for the treatment of a variety of diseases. Therefore, a better understanding of…”
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Selectivity limits of and opportunities for ion pair chromatographic separation of oligonucleotides by Enmark, Martin, Harun, Said, Samuelsson, Jörgen, Örnskov, Eivor, Thunberg, Linda, Dahlén, Anders, Fornstedt, Torgny

“…•Key parameters for increasing selectivity were fundamentally investigated.•Oligonucleotide retention is predominantly driven by electrostatic…”
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Cross-Species Translation of Biophase Half-Life and Potency of GalNAc-Conjugated siRNAs by Boianelli, Alessandro, Aoki, Yasunori, Ivanov, Maxim, Dahlén, Anders, Gennemark, Peter

“…Small interfering RNAs (siRNAs) with -acetylgalactosamine (GalNAc) conjugation for improved liver uptake represent an emerging class of drugs to treat liver…”
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Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein by Davies, Nigel, Hovdal, Daniel, Edmunds, Nicholas, Nordberg, Peter, Dahlén, Anders, Dabkowska, Aleksandra, Arteta, Marianna Yanez, Radulescu, Aurel, Kjellman, Tomas, Höijer, Andreas, Seeliger, Frank, Holmedal, Elin, Andihn, Elisabeth, Bergenhem, Nils, Sandinge, Ann-Sofie, Johansson, Camilla, Hultin, Leif, Johansson, Marie, Lindqvist, Johnny, Björsson, Liselotte, Jing, Yujia, Bartesaghi, Stefano, Lindfors, Lennart, Andersson, Shalini

“…Lipid nanoparticles (LNPs) are the most clinically advanced delivery system for RNA-based drugs but have predominantly been investigated for intravenous and…”
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Synthesis and Photophysical Characterization of a pH‐Sensitive Quadracyclic Uridine (qU) Analogue by Le, Hoang‐Ngoan, Kuchlyan, Jagannath, Baladi, Tom, Albinsson, Bo, Dahlén, Anders, Wilhelmsson, L. Marcus

“…Fluorescent base analogues (FBAs) have become useful tools for applications in biophysical chemistry, chemical biology, live‐cell imaging, and RNA…”
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Synthesis of Diverse α‐Fluoroalkoxyaryl Derivatives and Their Use for the Generation of Fluorinated Macrocycles by Cogswell, Thomas J., Dahlén, Anders, Knerr, Laurent

“…Introduction of difluorinated functionality has emerged as a powerful means for conformational design with minimal steric footprint. Synthetic approaches for…”
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Distribution and biotransformation of therapeutic antisense oligonucleotides and conjugates by Weidolf, Lars, Björkbom, Anders, Dahlén, Anders, Elebring, Marie, Gennemark, Peter, Hölttä, Mikko, Janzén, David, Li, XueQing, Andersson, Shalini

“…[Display omitted] •Targeting ASOs to other organs than the liver is currently challenging.•Early generation of disposition data supports regulatory…”
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Interbase FRET in RNA: from A to Z by Füchtbauer, Anders F, Wranne, Moa S, Bood, Mattias, Weis, Erik, Pfeiffer, Pauline, Nilsson, Jesper R, Dahlén, Anders, Grøtli, Morten, Wilhelmsson, L Marcus

“…Abstract Interbase FRET can reveal highly detailed information about distance, orientation and dynamics in nucleic acids, complementing the existing structure…”
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Tissue pharmacokinetics of antisense oligonucleotides by Bäckström, Erica, Bonetti, Alessandro, Johnsson, Per, Öhlin, Stefan, Dahlén, Anders, Andersson, Patrik, Andersson, Shalini, Gennemark, Peter

“…Pharmacokinetics (PK) of antisense oligonucleotides (ASOs) is characterized by rapid distribution from plasma to tissue and slow terminal plasma elimination…”
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Discovery of AZD6642, an Inhibitor of 5‑Lipoxygenase Activating Protein (FLAP) for the Treatment of Inflammatory Diseases by Lemurell, Malin, Ulander, Johan, Winiwarter, Susanne, Dahlén, Anders, Davidsson, Öjvind, Emtenäs, Hans, Broddefalk, Johan, Swanson, Marianne, Hovdal, Daniel, Plowright, Alleyn T, Pettersen, Anna, Rydén-Landergren, Marie, Barlind, Jonas, Llinas, Antonio, Herslöf, Margareta, Drmota, Tomas, Sigfridsson, Kalle, Moses, Sara, Whatling, Carl

“…A drug discovery program in search of novel 5-lipoxygenase activating protein (FLAP) inhibitors focused on driving a reduction in lipophilicity with maintained…”
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Metabolic RNA labeling in non-engineered cells following spontaneous uptake of fluorescent nucleoside phosphate analogues by Pfeiffer, Pauline, Nilsson, Jesper R, Gallud, Audrey, Baladi, Tom, Le, Hoang-Ngoan, Bood, Mattias, Lemurell, Malin, Dahlén, Anders, Grøtli, Morten, Esbjörner, Elin K, Wilhelmsson, L Marcus

“…RNA and its building blocks play central roles in biology and have become increasingly important as therapeutic agents and targets. Hence, probing and…”
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Fluorescent base analogues in gapmers enable stealth labeling of antisense oligonucleotide therapeutics by Nilsson, Jesper R., Baladi, Tom, Gallud, Audrey, Baždarević, Dženita, Lemurell, Malin, Esbjörner, Elin K., Wilhelmsson, L. Marcus, Dahlén, Anders

“…To expand the antisense oligonucleotide (ASO) fluorescence labeling toolbox beyond covalent conjugation of external dyes ( e.g. ATTO-, Alexa Fluor-, or cyanine…”
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Interbase-FRET binding assay for pre-microRNAs by Bood, Mattias, del Nogal, Anna Wypijewska, Nilsson, Jesper R., Edfeldt, Fredrik, Dahlén, Anders, Lemurell, Malin, Wilhelmsson, L. Marcus, Grøtli, Morten

“…The aberrant expression of microRNAs (miRs) has been linked to several human diseases. A promising approach for targeting these anomalies is the use of…”
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Samarium(II) Iodide Mediated Reductions − Influence of Various Additives by Dahlén, Anders, Hilmersson, Göran

“…Samarium(II) iodide is a one‐electron transfer reagent that has become highly appreciated as a mild and selective reducing agent in recent years. It has been…”
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Getting DNA and RNA out of the dark with 2CNqA: a bright adenine analogue and interbase FRET donor by Wypijewska del Nogal, Anna, Füchtbauer, Anders F, Bood, Mattias, Nilsson, Jesper R, Wranne, Moa S, Sarangamath, Sangamesh, Pfeiffer, Pauline, Rajan, Vinoth Sundar, El-Sagheer, Afaf H, Dahlén, Anders, Brown, Tom, Grøtli, Morten, Wilhelmsson, L Marcus

“…Abstract With the central role of nucleic acids there is a need for development of fluorophores that facilitate the visualization of processes involving…”
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Mechanistic Study of the SmI2/H2O/Amine-Mediated Reduction of Alkyl Halides:  Amine Base Strength (pK BH + ) Dependent Rate by Dahlén, Anders, Hilmersson, Göran

“…The kinetics of the SmI2/H2O/amine-mediated reduction of 1-chlorodecane has been studied in detail. The rate of reaction is first order in amine and…”
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Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa) by Brink, Mikael, Dahlén, Anders, Olsson, Thomas, Polla, Magnus, Svensson, Tor

“…A series of 4,5,6,7-tetrahydro-1H-benzimidazole-5-carboxylic acid and 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid derivatives designed as…”
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