Search Results - "Dahlberg, CIM"

Natural Killer Cell-Based Therapies Targeting Cancer: Possible Strategies to Gain and Sustain Anti-Tumor Activity by Dahlberg, Carin I M, Sarhan, Dhifaf, Chrobok, Michael, Duru, Adil D, Alici, Evren

“…Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill tumor cells without the requirement of prior antigen exposure…”
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Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive by Keszei, Marton, Record, Julien, Kritikou, Joanna S, Wurzer, Hannah, Geyer, Chiara, Thiemann, Meike, Drescher, Paul, Brauner, Hanna, Köcher, Laura, James, Jaime, He, Minghui, Baptista, Marisa Ap, Dahlberg, Carin Im, Biswas, Amlan, Lane, David P, Song, Wenxia, Pütsep, Katrin, Vandenberghe, Peter, Snapper, Scott B, Westerberg, Lisa S

“…Congenital neutropenia is characterized by low absolute neutrophil numbers in blood, leading to recurrent bacterial infections, and patients often require…”
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Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive by Keszei, Marton, Record, Julien, Kritikou, Joanna S, Wurzer, Hannah, Geyer, Chiara, Thiemann, Meike, Drescher, Paul, Brauner, Hanna, Köcher, Laura, James, Jaime, He, Minghui, Baptista, Marisa Ap, Dahlberg, Carin Im, Biswas, Amlan, Lain, Sonia, Lane, David P, Song, Wenxia, Pütsep, Katrin, Vandenberghe, Peter, Snapper, Scott B, Westerberg, Lisa S

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N-wasp is essential for the negative regulation of B cell receptor signaling by Liu, Chaohong, Bai, Xiaoming, Wu, Junfeng, Sharma, Shruti, Upadhyaya, Arpita, Dahlberg, Carin I M, Westerberg, Lisa S, Snapper, Scott B, Zhao, Xiaodong, Song, Wenxia

“…Negative regulation of receptor signaling is essential for controlling cell activation and differentiation. In B-lymphocytes, the down-regulation of B-cell…”
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Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo by Joly, Anne-Laure, Liu, Sang, Dahlberg, Carin I.M, Mailer, Reiner K.W, Westerberg, Lisa S, Andersson, John

“…Abstract The forkhead/winged-helix transcription factor FOXP3 confers suppressive ability to CD4+ FOXP3+ regulatory T (Treg) cells. Human Treg cells express…”
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Assessment of T Cell Receptor Complex Expression Kinetics in Natural Killer Cells by Rasul, Khder H., Hussain, Alamdar, Reilly, Hazel, Karvouni, Maria, Dahlberg, Carin I. M., Al-Attar, Mustafa S., Wagner, Arnika K., Alici, Evren, Mohammad, Dara K.

“…Among the polypeptides that comprise the T cell receptor (TCR), only CD3ζ is found in Natural Killer (NK) cells, where it transmits signals from activating…”
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N-WASP is required for B-cell–mediated autoimmunity in Wiskott-Aldrich syndrome by Volpi, Stefano, Santori, Elettra, Abernethy, Katrina, Mizui, Masayuki, Dahlberg, Carin I.M., Recher, Mike, Capuder, Kelly, Csizmadia, Eva, Ryan, Douglas, Mathew, Divij, Tsokos, George C., Snapper, Scott, Westerberg, Lisa S., Thrasher, Adrian J., Candotti, Fabio, Notarangelo, Luigi D.

“…Mutations of the Wiskott-Aldrich syndrome gene (WAS) are responsible for Wiskott-Aldrich syndrome (WAS), a disease characterized by thrombocytopenia, eczema,…”
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Functional Assessment for Clinical Use of Serum-Free Adapted NK-92 Cells by Chrobok, Michael, Dahlberg, Carin I M, Sayitoglu, Ece Canan, Beljanski, Vladimir, Nahi, Hareth, Gilljam, Mari, Stellan, Birgitta, Sutlu, Tolga, Duru, Adil Doganay, Alici, Evren

“…Natural killer (NK) cells stand out as promising candidates for cellular immunotherapy due to their capacity to kill malignant cells. However, the therapeutic…”
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The Rho GTPase Cdc42 Is Essential for the Activation and Function of Mature B Cells by Gerasimcik, Natalija, Dahlberg, Carin I M, Baptista, Marisa A P, Massaad, Michel J, Geha, Raif S, Westerberg, Lisa S, Severinson, Eva

“…The Rho GTPase Cdc42 coordinates regulation of the actin and the microtubule cytoskeleton by binding and activating the Wiskott-Aldrich syndrome protein. We…”
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IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo by Kritikou, Joanna S., Dahlberg, Carin I. M., Baptista, Marisa A. P., Wagner, Arnika K., Banerjee, Pinaki P., Gwalani, Lavesh Amar, Poli, Cecilia, Panda, Sudeepta K., Kärre, Klas, Kaech, Susan M., Wermeling, Fredrik, Andersson, John, Orange, Jordan S., Brauner, Hanna, Westerberg, Lisa S.

“…To kill target cells, natural killer (NK) cells organize signaling from activating and inhibitory receptors to form a lytic synapse. Wiskott-Aldrich syndrome…”
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The Small Rho GTPases Rac1 and Rac2 Are Important for T-Cell Independent Antigen Responses and for Suppressing Switching to IgG2b in Mice by Gerasimčik, Natalija, He, Minghui, Dahlberg, Carin I M, Kuznetsov, Nikolai V, Severinson, Eva, Westerberg, Lisa S

“…The Rho GTPases Cdc42, Rac1, and Rac2 coordinate receptor signaling to cell adhesion, migration, and proliferation. Deletion of Rac1 and Rac2 early during B…”
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Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies by Dahlberg, Carin I.M, Torres, Magda-Liz, Petersen, Sven H, Baptista, Marisa A.P, Keszei, Marton, Volpi, Stefano, Grasset, Emilie K, Karlsson, Mikael C.I, Walter, Jolan E, Snapper, Scott B, Notarangelo, Luigi D, Westerberg, Lisa S

“…Abstract Humoral immunodeficiency caused by mutations in the Wiskott-Aldrich syndrome protein (WASp) is associated with failure to respond to common pathogens…”
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A novel mouse model for the hyper-IgM syndrome: a spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutation by Dahlberg, Carin I M, He, Minghui, Visnes, Torkild, Torres, Magda Liz, Cortizas, Elena M, Verdun, Ramiro E, Westerberg, Lisa S, Severinson, Eva, Ström, Lena

“…We describe a spontaneously derived mouse line that completely failed to induce Ig class switching in vitro and in vivo. The mice inherited abolished IgG serum…”
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Optimized genetic modification of primary human NK cells by Wagner, AK, Chrobok, M, Hussain, A, Gilljam, M, Dahlberg, CIM, Sutlu, T, Duru, AD, Nahi, H, Lundqvist, A, Ljunggren, HG, Alici, E

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Adaption of NK-92 cells to serum-free culture with inherent anti-tumor response: NK-92 cells stand strong in a serum-free milieu by Chrobok, M, Dahlberg, CIM, Sayitoglu, C, Nahi, H, Sarhan, D, Gilljam, M, Stellan, B, Sutlu, T, Duru, AD, Alici, E

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Deletion of WASp and N-WASp in B Cells Cripple the Germinal Center Response and Induces Production of IgM Autoantibodies by Dahlberg, CIM, Torres, ML, Petersen, SH, Baptista, MAP, Keszei, M, Volpi, S, Grasset, EK, Karlsson, MCI, Walter, JE, Snapper, SB, Notarangelo, LD, Westerberg, LS

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