Search Results - "Dahl, Andy"

A robust model for cell type-specific interindividual variation in single-cell RNA sequencing data by Chen, Minhui, Dahl, Andy

“…Single-cell RNA sequencing (scRNA-seq) has been widely used to characterize cell types based on their average gene expression profiles. However, most studies…”
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Cross-trait assortative mating is widespread and inflates genetic correlation estimates by Border, Richard, Athanasiadis, Georgios, Buil, Alfonso, Schork, Andrew J, Cai, Na, Young, Alexander I, Werge, Thomas, Flint, Jonathan, Kendler, Kenneth S, Sankararaman, Sriram, Dahl, Andy W, Zaitlen, Noah A

“…The observation of genetic correlations between disparate human traits has been interpreted as evidence of widespread pleiotropy. Here, we introduce…”
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A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits by Dahl, Andy, Nguyen, Khiem, Cai, Na, Gandal, Michael J., Flint, Jonathan, Zaitlen, Noah

“…Gene-environment interactions (GxE) can be fundamental in applications ranging from functional genomics to precision medicine and is a conjectured source of…”
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Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression by Peterson, Roseann E, Cai, Na, Dahl, Andy W, Bigdeli, Tim B, Edwards, Alexis C, Webb, Bradley T, Bacanu, Silviu-Alin, Zaitlen, Noah, Flint, Jonathan, Kendler, Kenneth S

“…Objective:The extent to which major depression is the outcome of a single biological mechanism or represents a final common pathway of multiple disease…”
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Reverse GWAS: Using genetics to identify and model phenotypic subtypes by Dahl, Andy, Cai, Na, Ko, Arthur, Laakso, Markku, Pajukanta, Päivi, Flint, Jonathan, Zaitlen, Noah

“…Recent and classical work has revealed biologically and medically significant subtypes in complex diseases and traits. However, relevant subtypes are often…”
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Genetic Influences on Disease Subtypes by Dahl, Andy, Zaitlen, Noah

“…Disease classification, or nosology, was historically driven by careful examination of clinical features of patients. As technologies to measure and understand…”
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Factorizing polygenic epistasis improves prediction and uncovers biological pathways in complex traits by Tang, David, Freudenberg, Jerome, Dahl, Andy

“…Epistasis is central in many domains of biology, but it has not yet been proven useful for understanding the etiology of complex traits. This is partly because…”
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On Negative Heritability and Negative Estimates of Heritability by Steinsaltz, David, Dahl, Andy, Wachter, Kenneth W

“…Abstract We consider the problem of interpreting negative maximum likelihood estimates of heritability that sometimes arise from popular statistical models of…”
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Adjusting for Principal Components of Molecular Phenotypes Induces Replicating False Positives by Dahl, Andy, Guillemot, Vincent, Mefford, Joel, Aschard, Hugues, Zaitlen, Noah

“…High-throughput measurements of molecular phenotypes provide an unprecedented opportunity to model cellular processes and their impact on disease. These highly…”
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46. DISENTANGLE THE GENETIC HETEROGENEITY OF MAJOR DEPRESSIVE DISORDER (MDD) by Huang, Lianyun, Rietkerk, Jolien, Krebs, Morten, Schork, Andrew, Werge, Thomas, Dahl, Andy, Cai, Na

“…Major Depressive Disorder (MDD) is a highly prevalent and heterogeneous disease. MDD patients diagnosed with the diagnostic and statistical manual of mental…”
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COORDINATED EPISTASIS DETECTS HETEROGENOUS PATHWAYS ACROSS PSYCHIATRIC DISORDERS AND COMORBIDITIES by Rietkerk, Jolien, Krebs, Morten, Huang, Lianyun, Hellberg, Kajsa-Lotta Georgii, Werge, Thomas, Schork, Andrew, Dahl, Andy, Cai, Na

“…Cross-disorder analyses in psychiatry often center around genetic correlation, which quantifies the average similarity of genetic effects across two disorders…”
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A model and test for coordinated polygenic epistasis in complex traits by Sheppard, Brooke, Rappoport, Nadav, Loh, Po-Ru, Sanders, Stephan J., Zaitlen, Noah, Dahl, Andy

“…Interactions between genetic variants—epistasis—is pervasive in model systems and can profoundly impact evolutionary adaption, population disease dynamics,…”
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Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries by An, Ulzee, Pazokitoroudi, Ali, Alvarez, Marcus, Huang, Lianyun, Bacanu, Silviu, Schork, Andrew J., Kendler, Kenneth, Pajukanta, Päivi, Flint, Jonathan, Zaitlen, Noah, Cai, Na, Dahl, Andy, Sankararaman, Sriram

“…Biobanks that collect deep phenotypic and genomic data across many individuals have emerged as a key resource in human genetics. However, phenotypes in…”
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Understanding the complexities of omnichannel retailing through a service-dominant logic framework: exploring the role of digitalization in the retail ecosystem by Gibson, Samantha, Dahl, Andrew J., Hsu, Maxwell K., Moreno, Gabriel

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On Negative Heritability and Negative Estimates of Heritability by Steinsaltz, David, Dahl, Andy, Wachter, Kenneth W

“…We consider the problem of interpreting negative maximum likelihood estimates of heritability that sometimes arise from popular statistical models of additive…”
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14. COORDINATED EPISTASIS REVEALS SYMPTOM-SPECIFIC POLYGENIC PATHWAY INTERACTIONS IN MAJOR DEPRESSIVE DISORDER by Rietkerk, Jolien, Huang, Lianyun, Appadurai, Vivek, Pons, Victoria Trintrade, van Loo, Hanna, Garvert, Linda, van der Auwera-Palitschka, Sandra, Adams, Mark, Grabe, Hans Jörgen, Schork, Andrew, Müller-Myhsok, Bertram, Dahl, Andy, Cai, Na

“…Patients diagnosed with Major Depressive Disorder (MDD) often exhibit very diverse symptom profiles, some of which have no symptoms in common. As a result, MDD…”
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83. FAMILY HISTORY SCORES COMPLEMENT POLYGENIC SCORE DESCRIPTIONS OF PSYCHIATRIC GENETIC ARCHITECTURE: THEORY AND PRACTICE by Krebs, Morten, Hellberg, Kajsa-Lotta Georgii, Appadurai, Vivek, Ohlsson, Henrik, Vilhjalmsson, Bjarni, Bacanu, Silviu-Alin, Flint, Jonathan, Cai, Na, Zaitlen, Noah, Ingason, Andres, Buil, Alfonso, Dahl, Andy, Kendler, Kenneth, Werge, Thomas, Schork, Andrew

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MOLECULAR GENETIC ANALYSIS SUBDIVIDED BY ADVERSITY EXPOSURE SUGGESTS ETIOLOGIC HETEROGENEITY IN MAJOR DEPRESSION by Peterson, Roseann, Cai, Na, Dahl, Andy, Bigdeli, Tim, Edwards, Alexis, Webb, Bradley, Bacanu, Silviu, Zaitlen, Noah, Flint, Jonathan, Kendler, Kenneth

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22 - MOLECULAR GENETIC ANALYSIS SUBDIVIDED BY ADVERSITY EXPOSURE SUGGESTS ETIOLOGIC HETEROGENEITY IN MAJOR DEPRESSION by Peterson, Roseann, Cai, Na, Dahl, Andy, Bigdeli, Tim, Edwards, Alexis, Webb, Bradley, Bacanu, Silviu, Zaitlen, Noah, Flint, Jonathan, Kendler, Kenneth

“…The extent to which Major Depression (MD) is the outcome of a single biological mechanism or represents a final common pathway of multiple disease processes…”
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Network inference in matrix-variate Gaussian models with non-independent noise by Dahl, Andy, Hore, Victoria, Iotchkova, Valentina, Marchini, Jonathan

“…Inferring a graphical model or network from observational data from a large number of variables is a well studied problem in machine learning and computational…”
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