Search Results - "Dahiya, Rashmi"

Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errors by Hu, Qing, Espejo Valle-Inclán, Jose, Dahiya, Rashmi, Guyer, Alison, Mazzagatti, Alice, Maurais, Elizabeth G., Engel, Justin L., Lu, Huiming, Davis, Anthony J., Cortés-Ciriano, Isidro, Ly, Peter

“…Mitotic errors generate micronuclei entrapping mis-segregated chromosomes, which are susceptible to catastrophic fragmentation through chromothripsis. The…”
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Discovery of Harmaline as a Potent Inhibitor of Sphingosine Kinase-1: A Chemopreventive Role in Lung Cancer by Roy, Sonam, Mohammad, Taj, Gupta, Preeti, Dahiya, Rashmi, Parveen, Shahnaz, Luqman, Suaib, Hasan, Gulam Mustafa, Hassan, Md. Imtaiyaz

“…The sphingosine kinase-1/sphingosine-1-phosphate pathway is linked with the cancer progression and survival of the chemotherapy-challenged cells. Sphingosine…”
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Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging by Dahiya, Rashmi, Mohammad, Taj, Alajmi, Mohamed F, Rehman, Md Tabish, Hasan, Gulam Mustafa, Hussain, Afzal, Hassan, Md Imtaiyaz

“…Aging represents a significant biological process having strong associations with cancer, diabetes, and neurodegenerative and cardiovascular disorders, which…”
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Mechanistic origins of diverse genome rearrangements in cancer by Dahiya, Rashmi, Hu, Qing, Ly, Peter

“…Cancer genomes frequently harbor structural chromosomal rearrangements that disrupt the linear DNA sequence order and copy number. To date, diverse classes of…”
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Mutational analysis of TAF 6 revealed the essential requirement of the histone‐fold domain and the HEAT repeat domain for transcriptional activation by Dahiya, Rashmi, Natarajan, Krishnamurthy

“…TAF 6, bearing the histone H4‐like histone‐fold domain ( HFD ), is a subunit of the core TAF module in TFIID and SAGA transcriptional regulatory complexes. We…”
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Abstract A014: Modeling recurrent chromosomal alterations in renal cell carcinoma evolution by Dahiya, Rashmi, Ly, Peter

“…The loss of one copy of chromosome 3p represents an early truncal genetic event in the majority of clear cell renal cell carcinoma (ccRCC) tumors. Chromosome…”
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Investigation of inhibitory potential of quercetin to the pyruvate dehydrogenase kinase 3: Towards implications in anticancer therapy by Dahiya, Rashmi, Mohammad, Taj, Roy, Sonam, Anwar, Saleha, Gupta, Preeti, Haque, Anzarul, Khan, Parvez, Kazim, Syed Naqui, Islam, Asimul, Ahmad, Faizan, Hassan, Md. Imtaiyaz

“…Pyruvate dehydrogenase kinase 3 (PDK3) is a mitochondrial protein, has recently been considered as a potential pharmacological target for varying types of…”
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Mutational analysis of TAF6 revealed the essential requirement of the histone‐fold domain and the HEAT repeat domain for transcriptional activation by Dahiya, Rashmi, Natarajan, Krishnamurthy

“…TAF6, bearing the histone H4‐like histone‐fold domain (HFD), is a subunit of the core TAF module in TFIID and SAGA transcriptional regulatory complexes. We…”
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Evaluation of binding and inhibition mechanism of dietary phytochemicals with sphingosine kinase 1: Towards targeted anticancer therapy by Gupta, Preeti, Mohammad, Taj, Dahiya, Rashmi, Roy, Sonam, Noman, Omar Mohammed Ali, Alajmi, Mohamed F., Hussain, Afzal, Hassan, Md. Imtaiyaz

“…Sphingosine kinase 1 (SphK1) has recently gained attention as a potential drug target for its association with cancer and other inflammatory diseases. Here, we…”
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Molecular interaction studies on ellagic acid for its anticancer potential targeting pyruvate dehydrogenase kinase 3 by Dahiya, Rashmi, Mohammad, Taj, Gupta, Preeti, Haque, Anzarul, Alajmi, Mohamed F, Hussain, Afzal, Hassan, Md. Imtaiyaz

“…Pyruvate dehydrogenase kinase 3 (PDK3) plays a central role in the cancer metabolic switch through the reversible phosphorylation of pyruvate dehydrogenase…”
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Mitotic clustering of pulverized chromosomes from micronuclei by Lin, Yu-Fen, Hu, Qing, Mazzagatti, Alice, Valle-Inclán, Jose Espejo, Maurais, Elizabeth G., Dahiya, Rashmi, Guyer, Alison, Sanders, Jacob T., Engel, Justin L., Nguyen, Giaochau, Bronder, Daniel, Bakhoum, Samuel F., Cortés-Ciriano, Isidro, Ly, Peter

“…Complex genome rearrangements can be generated by the catastrophic pulverization of missegregated chromosomes trapped within micronuclei through a process…”
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Functional implications of pH-induced conformational changes in the Sphingosine kinase 1 by Gupta, Preeti, Khan, Faez Iqbal, Roy, Sonam, Anwar, Saleha, Dahiya, Rashmi, Alajmi, Mohammed F., Hussain, Afzal, Rehman, Md. Tabish, Lai, Dakun, Hassan, Md. Imtaiyaz

“…Sphingosine kinase 1 (SphK1) catalyzes the conversion of sphingosine to sphingosine-1-phosphate that acts as a bioactive signalling molecule, and regulates…”
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Identification of High-Affinity Inhibitors of Cyclin-Dependent Kinase 2 Towards Anticancer Therapy by Mohammad, Taj, Batra, Sagar, Dahiya, Rashmi, Baig, Mohammad Hassan, Rather, Irfan Ahmad, Dong, Jae-June, Hassan, Imtaiyaz

“…Cyclin-dependent kinase 2 (CDK2) is an essential protein kinase involved in the cell cycle regulation. The abnormal activity of CDK2 is associated with cancer…”
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Effect of pH on the structure and function of pyruvate dehydrogenase kinase 3: Combined spectroscopic and MD simulation studies by Anwar, Saleha, Kar, Rajiv K., Haque, Md. Anzarul, Dahiya, Rashmi, Gupta, Preeti, Islam, Asimul, Ahmad, Faizan, Hassan, Md. Imtaiyaz

“…Pyruvate dehydrogenase kinase-3 (PDK3) plays important role in the glucose metabolism and is associated with cancer progression, and thus being considered as…”
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SETD2 safeguards the genome against isochromosome formation by Mason, Frank M, Kounlavong, Emily S, Tebeje, Anteneh T, Dahiya, Rashmi, Guess, Tiffany, Khan, Abid, Vlach, Logan, Norris, Stephen R, Lovejoy, Courtney A, Dere, Ruhee, Strahl, Brian D, Ohi, Ryoma, Ly, Peter, Walker, Cheryl Lyn, Rathmell, W Kimryn

“…Isochromosomes are mirror-imaged chromosomes with simultaneous duplication and deletion of genetic material which may contain two centromeres to create…”
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Correction for Saint et al., "The TAF9 C-Terminal Conserved Region Domain Is Required for SAGA and TFIID Promoter Occupancy To Promote Transcriptional Activation" by Saint, Malika, Sawhney, Sonal, Sinha, Ishani, Singh, Rana Pratap, Dahiya, Rashmi, Thakur, Anushikha, Siddharthan, Rahul, Natarajan, Krishnamurthy

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The TAF9 C-Terminal Conserved Region Domain Is Required for SAGA and TFIID Promoter Occupancy To Promote Transcriptional Activation by Saint, Malika, Sawhney, Sonal, Sinha, Ishani, Singh, Rana Pratap, Dahiya, Rashmi, Thakur, Anushikha, Siddharthan, Rahul, Natarajan, Krishnamurthy

“…A common function of the TFIID and SAGA complexes, which are recruited by transcriptional activators, is to deliver TBP to promoters to stimulate…”
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Molecular interaction studies on ellagic acid for its anticancer potential targeting pyruvate dehydrogenase kinase 3 by Dahiya, Rashmi, Mohammad, Taj, Gupta, Preeti, Haque, Anzarul, Alajmi, Mohamed F, Hussain, Afzal, Hassan, Md Imtaiyaz

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Investigating the structural features of chromodomain proteins in the human genome and predictive impacts of their mutations in cancers by Dahiya, Rashmi, Naqvi, Ahmad Abu Turab, Mohammad, Taj, Alajmi, Mohamed F., Rehman, Md. Tabish, Hussain, Afzal, Hassan, Md. Imtaiyaz

“…Epigenetic readers are specific proteins which recognize histone marks and represents the underlying mechanism for chromatin regulation. Histone H3 lysine…”
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Abstract B016: SETD2 safeguards the genome against isochromosome formation by Mason, Frank M., Tebeje, Anteneh T., Kounlavong, Emily S., Dahiya, Rashmi, Vlach, Logan, Guess, Tiffany, Dere, Ruhee, Ohi, Ryoma, Ly, Peter, Walker, Cheryl L., Rathmell, W. Kimryn

“…This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR012) of the…”
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