Search Results - "Daheng He"

p300/CBP inhibition enhances the efficacy of programmed death-ligand 1 blockade treatment in prostate cancer by Liu, Jinghui, He, Daheng, Cheng, Lijun, Huang, Changkun, Zhang, Yanquan, Rao, Xiongjian, Kong, Yifan, Li, Chaohao, Zhang, Zhuangzhuang, Liu, Jinpeng, Jones, Karrie, Napier, Dana, Lee, Eun Y., Wang, Chi, Liu, Xiaoqi

“…Blockade of programmed death-ligand 1 (PD-L1) by therapeutic antibodies has shown to be a promising strategy in cancer therapy, yet clinical response in many…”
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Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression by Guo, Yubin, Ye, Qing, Deng, Pan, Cao, Yanan, He, Daheng, Zhou, Zhaohe, Wang, Chi, Zaytseva, Yekaterina Y., Schwartz, Charles E., Lee, Eun Y., Evers, B. Mark, Morris, Andrew J., Liu, Side, She, Qing-Bai

“…Dysregulation of polyamine metabolism has been linked to the development of colorectal cancer (CRC), but the underlying mechanism is incompletely…”
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Combating acquired resistance to MAPK inhibitors in melanoma by targeting Abl1/2-mediated reactivation of MEK/ERK/MYC signaling by Tripathi, Rakshamani, Liu, Zulong, Jain, Aditi, Lyon, Anastasia, Meeks, Christina, Richards, Dana, Liu, Jinpeng, He, Daheng, Wang, Chi, Nespi, Marika, Rymar, Andrey, Wang, Peng, Wilson, Melissa, Plattner, Rina

“…Metastatic melanoma remains an incurable disease for many patients due to the limited success of targeted and immunotherapies. BRAF and MEK inhibitors reduce…”
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Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells by Drury, James, Rychahou, Piotr G, He, Daheng, Jafari, Naser, Wang, Chi, Lee, Eun Y, Weiss, Heidi L, Evers, Bernard Mark, Zaytseva, Yekaterina Y

“…Fatty acid synthase, a key enzyme of lipogenesis, is an attractive therapeutic target in cancer. The novel fatty acid synthase inhibitor, TVB-3664, shows…”
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Single-cell analysis identifies PLK1 as a driver of immunosuppressive tumor microenvironment in LUAD by Kong, Yifan, Li, Chaohao, Liu, Jinpeng, Wu, Sai, Zhang, Min, Allison, Derek B, Hassan, Faisal, He, Daheng, Wang, Xinyi, Mao, Fengyi, Zhang, Qiongsi, Zhang, Yanquan, Li, Zhiguo, Wang, Chi, Liu, Xiaoqi

“…PLK1 (Polo-like kinase 1) plays a critical role in the progression of lung adenocarcinoma (LUAD). Recent studies have unveiled that targeting PLK1 improves the…”
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Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues by Fan, Teresa Wm, Higashi, Richard M, Song, Huan, Daneshmandi, Saeed, Mahan, Angela L, Purdom, Matthew S, Bocklage, Therese J, Pittman, Thomas A, He, Daheng, Wang, Chi, Lane, Andrew N

“…Although Pembrolizumab-based immunotherapy has significantly improved lung cancer patient survival, many patients show variable efficacy and resistance…”
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Upregulation of CD36, a Fatty Acid Translocase, Promotes Colorectal Cancer Metastasis by Increasing MMP28 and Decreasing E-Cadherin Expression by Drury, James, Rychahou, Piotr G, Kelson, Courtney O, Geisen, Mariah E, Wu, Yuanyuan, He, Daheng, Wang, Chi, Lee, Eun Y, Evers, B Mark, Zaytseva, Yekaterina Y

“…Altered fatty acid metabolism continues to be an attractive target for therapeutic intervention in cancer. We previously found that colorectal cancer (CRC)…”
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Overexpression of Fatty Acid Synthase Upregulates Glutamine-Fructose-6-Phosphate Transaminase 1 and O-Linked N-Acetylglucosamine Transferase to Increase O-GlcNAc Protein Glycosylation and Promote Colorectal Cancer Growth by Drury, James, Geisen, Mariah E, Tessmann, Josiane Weber, Rychahou, Piotr G, Kelson, Courtney O, He, Daheng, Wang, Chi, Evers, B Mark, Zaytseva, Yekaterina Y

“…Fatty acid synthesis has been extensively investigated as a therapeutic target in cancers, including colorectal cancer (CRC). Fatty acid synthase (FASN), a key…”
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Phosphorylation of AHR by PLK1 promotes metastasis of LUAD via DIO2-TH signaling by Li, Chaohao, Allison, Derek B, He, Daheng, Mao, Fengyi, Wang, Xinyi, Rychahou, Piotr, Imam, Ibrahim A, Kong, Yifan, Zhang, Qiongsi, Zhang, Yanquan, Liu, Jinghui, Wang, Ruixin, Rao, Xiongjian, Wu, Sai, Evers, B Mark, Shao, Qing, Wang, Chi, Li, Zhiguo, Liu, Xiaoqi

“…Metastasis of lung adenocarcinoma (LUAD) is a major cause of death in patients. Aryl hydrocarbon receptor (AHR), an important transcription factor, is involved…”
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Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1 by Cui, Xiaojing, Zhang, Cuiping, Wang, Fang, Zhao, Xinghui, Wang, Shuxia, Liu, Jinpeng, He, Daheng, Wang, Chi, Yang, Feng-Chun, Tong, Sheng, Liang, Ying

“…Hematopoietic stem cells (HSCs) have the ability to self-renew and differentiate to all blood cell types. HSCs and their differentiated progeny show sex/gender…”
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Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer by Drury, James, Young, Lyndsay E A, Scott, Timothy L, Kelson, Courtney O, He, Daheng, Liu, Jinpeng, Wu, Yuanyan, Wang, Chi, Weiss, Heidi L, Fan, Teresa, Gentry, Matthew S, Sun, Ramon, Zaytseva, Yekaterina Y

“…Altered lipid metabolism is a potential target for therapeutic intervention in cancer. Overexpression of Fatty Acid Synthase (FASN) correlates with poor…”
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The RelB-BLNK Axis Determines Cellular Response to a Novel Redox-Active Agent Betamethasone during Radiation Therapy in Prostate Cancer by Chaiswing, Luksana, Xu, Fangfang, Zhao, Yanming, Thorson, Jon, Wang, Chi, He, Daheng, Lu, Jinpeng, Ellingson, Sally R, Zhong, Weixiong, Meyer, Kristy, Luo, Wei, St Clair, William, Clair, Daret St

“…Aberrant levels of reactive oxygen species (ROS) are potential mechanisms that contribute to both cancer therapy efficacy and the side effects of cancer…”
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Upregulation of Fatty Acid Synthase Increases Activity of β-Catenin and Expression of NOTUM to Enhance Stem-like Properties of Colorectal Cancer Cells by Kelson, Courtney O, Tessmann, Josiane Weber, Geisen, Mariah E, He, Daheng, Wang, Chi, Gao, Tianyan, Evers, B Mark, Zaytseva, Yekaterina Y

“…Dysregulated fatty acid metabolism is an attractive therapeutic target for colorectal cancer (CRC). We previously reported that fatty acid synthase (FASN), a…”
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Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity by Araujo, Nathalia, Sledziona, James, Noothi, Sunil K, Burikhanov, Ravshan, Hebbar, Nikhil, Ganguly, Saptadwipa, Shrestha-Bhattarai, Tripti, Zhu, Beibei, Katz, Wendy S, Zhang, Yi, Taylor, Barry S, Liu, Jinze, Chen, Li, Weiss, Heidi L, He, Daheng, Wang, Chi, Morris, Andrew J, Cassis, Lisa A, Nikolova-Karakashian, Mariana, Nagareddy, Prabhakar R, Melander, Olle, Evers, B Mark, Kern, Philip A, Rangnekar, Vivek M

“…Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains…”
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Co‐Targeting Plk1 and DNMT3a in Advanced Prostate Cancer by Zhang, Zhuangzhuang, Cheng, Lijun, Zhang, Qiongsi, Kong, Yifan, He, Daheng, Li, Kunyu, Rea, Matthew, Wang, Jianling, Wang, Ruixin, Liu, Jinghui, Li, Zhiguo, Yuan, Chongli, Liu, Enze, Fondufe‐Mittendorf, Yvonne N., Li, Lang, Han, Tao, Wang, Chi, Liu, Xiaoqi

“…Because there is no effective treatment for late‐stage prostate cancer (PCa) at this moment, identifying novel targets for therapy of advanced PCa is urgently…”
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Co‐Targeting Plk1 and DNMT3a in Advanced Prostate Cancer by Zhang, Zhuangzhuang, Cheng, Lijun, Zhang, Qiongsi, Kong, Yifan, He, Daheng, Li, Kunyu, Rea, Matthew, Wang, Jianlin, Wang, Ruixin, Liu, Jinghui, Li, Zhiguo, Yuan, Chongli, Liu, Enze, Fondufe‐Mittendorf, Yvonne N., Li, Lang, Wang, Chi, Liu, Xiaoqi, Han, Tao

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Nitrogen-rich carbon-supported ultrafine MoC nanoparticles for the hydrotreatment of oleic acid into diesel-like hydrocarbons by Wang, Fei, Zhang, Wenjuan, Jiang, Jianchun, Xu, Junming, Zhai, Qiaolong, Wei, Linshan, Long, Feng, Liu, Chao, Liu, Peng, Tan, Weihong, He, Daheng

“…[Display omitted] •Ultrafine molybdenum carbide supported on nitrogen-rich carbon (MoC/CN) are synthesized with a facile one-step route.•Molybdenum carbide…”
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Downregulation of EZH2 inhibits epithelial-mesenchymal transition in enzalutamide-resistant prostate cancer by Zhang, Zhuangzhuang, Wang, Xinyi, Kim, Miyeong, He, Daheng, Wang, Chi, Fong, Ka Wing, Liu, Xiaoqi

“…Androgen signaling inhibitors (ASI) have been approved for treatment of metastatic castration-resistant prostate cancer (mCRPC). However, the limited success…”
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Sex Dimorphism in the Bone Marrow Niche Contributes to Gender Difference in Mouse Hematopoiesis by Cui, Xiaojing, Yan, Bowen, Zhang, Cuiping, Zhao, Xinghui, Liu, Jinpeng, He, Daheng, Wang, Chi, Zhou, Daohong, Liang, Ying

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The PLOD2/succinate axis regulates the epithelial-mesenchymal plasticity and cancer cell stemness by Tong, Yuxin, Qi, Yifei, Xiong, Gaofeng, Li, Junyan, Scott, Timothy L, Chen, Jie, He, Daheng, Li, Linzhang, Wang, Chi, Lane, Andrew N, Xu, Ren

“…Aberrant accumulation of succinate has been detected in many cancers. However, the cellular function and regulation of succinate in cancer progression is not…”
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