Search Results - "Dahal, Gopal P."

Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase by Dahal, Gopal P., Viola, Ronald E.

“…The aspartate pathway, uniquely found in plants and microorganisms, offers novel potential targets for the development of new antimicrobial drugs. Aspartate…”
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Development of bisubstrate analog inhibitors of aspartate N‐acetyltransferase, a critical brain enzyme by Mutthamsetty, Vinay, Dahal, Gopal P., Wang, Qinzhe, Viola, Ronald E.

“…Canavan disease (CD) is a fatal leukodystrophy caused by mutations in the aspA gene coding for the enzyme aspartoacylase. Insufficient catalytic activity by…”
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Aspartate semialdehyde dehydrogenase inhibition suppresses the growth of the pathogenic fungus Candida albicans by Dahal, Gopal P., Launder, Dylan, McKeone, Katherine M. M., Hunter, Joseph P., Conti, Heather R., Viola, Ronald E.

“…Potent inhibitors of an essential microbial enzyme have been shown to be effective growth inhibitors of Candida albicans, a pathogenic fungus. C. albicans is…”
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Structure of a fungal form of aspartate‐semialdehyde dehydrogenase from Aspergillus fumigatus by Dahal, Gopal P., Viola, Ronald E.

“…Aspartate‐semialdehyde dehydrogenase (ASADH) functions at a critical junction in the aspartate biosynthetic pathway and represents a validated target for…”
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A Fragment Library Screening Approach to Identify Selective Inhibitors against an Essential Fungal Enzyme by Dahal, Gopal P, Viola, Ronald E

“…Pathogenic fungi represent a growing threat to human health, with an increase in the frequency of drug-resistant fungal infections. Identifying targets from…”
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Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase by Dahal, Gopal P., Viola, Ronald E.

“…Highlights: • Structure of an inhibitor bound to an essential fungal enzyme. • Effects of cofactor binding on oligomeric assembly. • Structure guided docking…”
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Structural and inhibitor screening studies of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans by Dahal, Gopal P, Viola, Ronald E

“…Abstract only Aspartate semialdehyde dehydrogenase (ASADH) functions at a critical junction in the aspartate biosynthetic pathway and represents a validated…”
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Crystal structures and small-angle X-ray scattering analysis of antifungal drug target aspartate semialdehyde dehydrogenase by Dahal, Gopal P., Qian, Shuo, Viola, Ronald E.

“…Abstract only…”
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Development of Selective Inhibitors against Enzymes Involved in the Aspartate Biosynthetic Pathway for Antifungal Drug Development by Dahal, Gopal P

“…Aspartate semialdehyde dehydrogenase (ASADH) functions at a critical junction in the aspartate biosynthetic pathway and represents a validated target for…”
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