Search Results - "Dahal, B. K."
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Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension
Published in The European respiratory journal (01-10-2010)“…An accumulating body of evidence incriminates Rho kinase (ROCK) in the pathogenesis of pulmonary hypertension (PH). The therapeutic efficacy of azaindole-1, a…”
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Inflammation, immunological reaction and role of infection in pulmonary hypertension
Published in Clinical microbiology and infection (01-01-2011)“…Inflammation underlies a wide variety of physiological and pathological processes. Acute inflammation is the initial response of the body to harmful stimuli…”
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Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation
Published in Journal of leukocyte biology (01-03-2005)“…Molecular markers, especially surface markers associated with type II, cytokine‐dependent, alternatively activated macrophages (aaMF), remain scarce. Besides…”
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Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment
Published in Thrombosis and haemostasis (01-12-2014)“…Chronic exposure to hypoxia induces a pronounced remodelling of the pulmonary vasculature leading to pulmonary hypertension (PH). The remodelling process also…”
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Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases
Published in American journal of respiratory and critical care medicine (15-04-2011)“…Platelet-derived growth factor (PDGF) plays a pivotal role in the pathobiology of pulmonary hypertension (PH) because it promotes pulmonary vascular…”
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Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β
Published in Pulmonary circulation (01-04-2011)“…Platelet-derived growth factor (PDGF) has been implicated in the pathobiology of vascular remodeling. The multikinase inhibitor imatinib that targets PDGF…”
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Novel Markers for Alternative Activation of Macrophages: Macrophage Galactose‐Type C‐Type Lectins 1 and 2
Published in Scandinavian journal of immunology (01-06-2004)“…In parallel with the Th1/Th2 dichotomy, macrophages are capable of developing into functionally and molecularly distinct subpopulations, due to differences in,…”
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