Search Results - "Dagmar Wilhelm"

Sex Determination and Gonadal Development in Mammals by Wilhelm, Dagmar, Palmer, Stephen, Koopman, Peter

“…Division of Molecular Genetics and Development and Australian Research Council Centre of Excellence in Biotechnology and Development, Institute for Molecular…”
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The makings of maleness: towards an integrated view of male sexual development by Koopman, Peter, Wilhelm, Dagmar

“…As the mammalian embryo develops, it must engage one of the two distinct programmes of gene activity, morphogenesis and organogenesis that characterize males…”
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Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a by Kuroki, Shunsuke, Matoba, Shogo, Akiyoshi, Mika, Matsumura, Yasuko, Miyachi, Hitoshi, Mise, Nathan, Abe, Kuniya, Ogura, Atsuo, Wilhelm, Dagmar, Koopman, Peter, Nozaki, Masami, Kanai, Yoshiakira, Shinkai, Yoichi, Tachibana, Makoto

“…Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone…”
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Development of mammalian ovary by Smith, Peter, Wilhelm, Dagmar, Rodgers, Raymond J

“…Pre-natal and early post-natal ovarian development has become a field of increasing importance over recent years. The full effects of perturbations of ovarian…”
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Signaling Pathways Involved in Mammalian Sex Determination and Gonad Development by Windley, Simon P, Wilhelm, Dagmar

“…The development of any organ system requires a complex interplay of cellular signals to initiate the differentiation and development of the heterogeneous cell…”
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Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development by Polanco, Juan Carlos, Wilhelm, Dagmar, Davidson, Tara-Lynne, Knight, Deon, Koopman, Peter

“…Male development in mammals is normally initiated by the Y-linked gene Sry, which activates expression of Sox9, leading to a cascade of gene activity required…”
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Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements by Schartl, Manfred, Schories, Susanne, Wakamatsu, Yuko, Nagao, Yusuke, Hashimoto, Hisashi, Bertin, Chloé, Mourot, Brigitte, Schmidt, Cornelia, Wilhelm, Dagmar, Centanin, Lazaro, Guiguen, Yann, Herpin, Amaury

“…Sex determination relies on a hierarchically structured network of genes, and is one of the most plastic processes in evolution. The evolution of…”
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R-spondin1-discovery of the long-missing, mammalian female-determining gene? by Wilhelm, Dagmar

“…Until recently, sex determination in mammals has often been described as a male determination process, with male differentiation being the active and dominant…”
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A new model of development of the mammalian ovary and follicles by Hummitzsch, Katja, Irving-Rodgers, Helen F, Hatzirodos, Nicholas, Bonner, Wendy, Sabatier, Laetitia, Reinhardt, Dieter P, Sado, Yoshikazu, Ninomiya, Yoshifumi, Wilhelm, Dagmar, Rodgers, Raymond J

“…Ovarian follicular granulosa cells surround and nurture oocytes, and produce sex steroid hormones. It is believed that during development the ovarian surface…”
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Retinoid Signaling Determines Germ Cell Fate in Mice by Bowles, Josephine, Knight, Deon, Smith, Christopher, Wilhelm, Dagmar, Richman, Joy, Mamiya, Satoru, Yashiro, Kenta, Chawengsaksophak, Kallayanee, Wilson, Megan J, Rossant, Janet, Hamada, Hiroshi, Koopman, Peter

“…Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified. We found that retinoic acid,…”
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Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice by Pitetti, Jean-Luc, Calvel, Pierre, Romero, Yannick, Conne, Béatrice, Truong, Vy, Papaioannou, Marilena D, Schaad, Olivier, Docquier, Mylène, Herrera, Pedro Luis, Wilhelm, Dagmar, Nef, Serge

“…Mouse sex determination provides an attractive model to study how regulatory genetic networks and signaling pathways control cell specification and cell fate…”
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TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway by Rossitto, Moïra, Déjardin, Stephanie, Rands, Chris M., Le Gras, Stephanie, Migale, Roberta, Rafiee, Mahmoud-Reza, Neirijnck, Yasmine, Pruvost, Alain, Nguyen, Anvi Laetitia, Bossis, Guillaume, Cammas, Florence, Le Gallic, Lionel, Wilhelm, Dagmar, Lovell-Badge, Robin, Boizet-Bonhoure, Brigitte, Nef, Serge, Poulat, Francis

“…Gonadal sexual fate in mammals is determined during embryonic development and must be actively maintained in adulthood. In the mouse ovary, oestrogen receptors…”
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Three-dimensional imaging of Prox1-EGFP transgenic mouse gonads reveals divergent modes of lymphangiogenesis in the testis and ovary by Svingen, Terje, François, Mathias, Wilhelm, Dagmar, Koopman, Peter

“…The lymphatic vasculature forms a specialized part of the circulatory system, being essential for maintaining tissue fluid homeostasis and for transport of…”
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FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development by Liu, Zhilin, Ren, Yi A, Pangas, Stephanie A, Adams, Jaye, Zhou, Wei, Castrillon, Diego H, Wilhelm, Dagmar, Richards, JoAnne S

“…The forkhead box (FOX), FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3…”
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FOXL2 and BMP2 Act Cooperatively to Regulate Follistatin Gene Expression during Ovarian Development by Kashimada, Kenichi, Pelosi, Emanuele, Chen, Huijun, Schlessinger, David, Wilhelm, Dagmar, Koopman, Peter

“…Follistatin is a secreted glycoprotein required for female sex determination and early ovarian development, but the precise mechanisms regulating follistatin…”
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Endothelial cell migration directs testis cord formation by Combes, Alexander N., Wilhelm, Dagmar, Davidson, Tara, Dejana, Elisabetta, Harley, Vincent, Sinclair, Andrew, Koopman, Peter

“…While the molecular cues initiating testis determination have been identified in mammals, the cellular interactions involved in generating a functional testis…”
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Expression of distinct RNAs from 3' untranslated regions by Mercer, Tim R, Wilhelm, Dagmar, Dinger, Marcel E, Soldà, Giulia, Korbie, Darren J, Glazov, Evgeny A, Truong, Vy, Schwenke, Maren, Simons, Cas, Matthaei, Klaus I, Saint, Robert, Koopman, Peter, Mattick, John S

“…The 3' untranslated regions (3'UTRs) of eukaryotic genes regulate mRNA stability, localization and translation. Here, we present evidence that large numbers of…”
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Cbx2, a Polycomb Group Gene, Is Required for Sry Gene Expression in Mice by Katoh-Fukui, Yuko, Miyabayashi, Kanako, Komatsu, Tomoko, Owaki, Akiko, Baba, Takashi, Shima, Yuichi, Kidokoro, Tomohide, Kanai, Yoshiakira, Schedl, Andreas, Wilhelm, Dagmar, Koopman, Peter, Okuno, Yasushi, Morohashi, Ken-ichirou

“…Mice lacking the function of the polycomb group protein CBX2 (chromobox homolog 2; also known as M33) show defects in gonadal, adrenal, and splenic…”
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ROBO2 restricts the nephrogenic field and regulates Wolffian duct–nephrogenic cord separation by Wainwright, Elanor N., Wilhelm, Dagmar, Combes, Alexander N., Little, Melissa H., Koopman, Peter

“…ROBO2 plays a key role in regulating ureteric bud (UB) formation in the embryo, with mutations in humans and mice leading to supernumerary kidneys. Previous…”
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SOX9 Regulates Prostaglandin D Synthase Gene Transcription in Vivo to Ensure Testis Development by Wilhelm, Dagmar, Hiramatsu, Ryuji, Mizusaki, Hirofumi, Widjaja, Laura, Combes, Alexander N., Kanai, Yoshiakira, Koopman, Peter

“…In mammals, male sex is determined by the Y-chromosomal gene Sry (sex-determining region of Y chromosome). The expression of Sry and subsequently Sox9 (SRY box…”
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