Search Results - "Dagklis, Antonis"

The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia by Vercruysse, Thomas, De Bie, Jolien, Neggers, Jasper E, Jacquemyn, Maarten, Vanstreels, Els, Schmid-Burgk, Jonathan L, Hornung, Veit, Baloglu, Erkan, Landesman, Yosef, Senapedis, William, Shacham, Sharon, Dagklis, Antonis, Cools, Jan, Daelemans, Dirk

“…Human exportin-1 (XPO1) is the key nuclear-cytoplasmic transport protein that exports different cargo proteins out of the nucleus. Inducing nuclear…”
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Monoclonal B-cell lymphocytosis in healthy blood donors: an unexpectedly common finding by Shim, Youn K., Rachel, Jane M., Ghia, Paolo, Boren, Jeff, Abbasi, Fatima, Dagklis, Antonis, Venable, Geri, Kang, Jiyeon, Degheidy, Heba, Plapp, Fred V., Vogt, Robert F., Menitove, Jay E., Marti, Gerald E.

“…Circulating monoclonal B cells may be detected in healthy adults, a condition called monoclonal B-cell lymphocytosis (MBL). MBL has also been identified in…”
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The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)–like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring by Dagklis, Antonis, Fazi, Claudia, Sala, Cinzia, Cantarelli, Valeria, Scielzo, Cristina, Massacane, Roberto, Toniolo, Daniela, Caligaris-Cappio, Federico, Stamatopoulos, Kostas, Ghia, Paolo

“…In the revised National Cancer Institute Working Group (NCI-WG)/International Workshop on Chronic Lymphocytic Leukemia (IWCLL) guidelines for CLL, CLL-like…”
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Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia by Dagklis, Antonis, Pauwels, Daphnie, Lahortiga, Idoya, Geerdens, Ellen, Bittoun, Emilie, Cauwelier, Barbara, Tousseyn, Thomas, Uyttebroeck, Anne, Maertens, Johan, Verhoef, Gregor, Vandenberghe, Peter, Cools, Jan

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HS1 has a central role in the trafficking and homing of leukemic B cells by Scielzo, Cristina, Bertilaccio, Maria T.S., Simonetti, Giorgia, Dagklis, Antonis, ten Hacken, Elisa, Fazi, Claudia, Muzio, Marta, Caiolfa, Valeria, Kitamura, Daisuke, Restuccia, Umberto, Bachi, Angela, Rocchi, Martina, Ponzoni, Maurilio, Ghia, Paolo, Caligaris-Cappio, Federico

“…The function of the intracellular protein hematopoietic cell–specific Lyn substrate-1 (HS1) in B lymphocytes is poorly defined. To investigate its role in…”
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KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function by Santoni de Sio, Francesca R., Massacand, Joanna, Barde, Isabelle, Offner, Sandra, Corsinotti, Andrea, Kapopoulou, Adamandia, Bojkowska, Karolina, Dagklis, Antonis, Fernandez, Marylise, Ghia, Paolo, Thomas, James H., Pinschewer, Daniel, Harris, Nicola, Trono, Didier

“…Chromatin remodeling is fundamental for B-cell differentiation. In the present study, we explored the role of KAP1, the cofactor of KRAB-ZFP transcriptional…”
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KIBRA gene methylation is associated with unfavorable biological prognostic parameters in chronic lymphocytic leukemia by Shinawi, Thoraia, Hill, Victoria, Dagklis, Antonis, Baliakas, Panagiotis, Stamatopoulos, Kostas, Agathanggelou, Angleo, Stankovic, Tanja, Maher, Eamonn R, Ghia, Paolo, Latif, Farida

“…Ras-association domain family (RASSF) members are a family of genes containing an RA domain in either the C-terminus (RASSF1-RASSF6) or in the N-terminus…”
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SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders by Simonetti, Giorgia, Bertilaccio, Maria Teresa Sabrina, Rodriguez, Tania Veliz, Apollonio, Benedetta, Dagklis, Antonis, Rocchi, Martina, Innocenzi, Anna, Casola, Stefano, Winkler, Thomas H, Nitschke, Lars, Ponzoni, Maurilio, Caligaris-Cappio, Federico, Ghia, Paolo

“…The sialic-acid-binding immunoglobulin-like lectin SIGLEC-G is a negative regulator of B-cell receptor-mediated calcium signaling. Its deficiency leads to…”
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Erratum to: Partial versus Productive Immunoglobulin Heavy Locus Rearrangements in Chronic Lymphocytic Leukemia: Implications for B-Cell Receptor Stereotypy by Tsakou, Eugenia, Agathagelidis, Andreas, Boudjoghra, Myriam, Raff, Thorsten, Dagklis, Antonis, Chatzouli, Maria, Smilevska, Tatjana, Bourikas, George, Merle-Beral, Helene, Manioudaki-Kavallieratou, Eleni, Anagnostopoulos, Achilles, Brüggemann, Monika, Davi, Frederic, Stamatopoulos, Kostas, Belessi, Chrysoula

“…Eugenia Tsakou, Andreas Agathagelidis, Myriam Boudjoghra, Thorsten Raff, Antonis Dagklis, Maria Chatzouli, Tatjana Smilevska, George Bourikas, Helene…”
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HOXA9 Cooperates with Activated JAK/STAT Signaling to Drive Leukemia Development by de Bock, Charles E, Demeyer, Sofie, Degryse, Sandrine, Verbeke, Delphine, Sweron, Bram, Gielen, Olga, Vandepoel, Roel, Vicente, Carmen, Vanden Bempt, Marlies, Dagklis, Antonis, Geerdens, Ellen, Bornschein, Simon, Gijsbers, Rik, Soulier, Jean, Meijerink, Jules P, Heinäniemi, Merja, Teppo, Susanna, Bouvy-Liivrand, Maria, Lohi, Olli, Radaelli, Enrico, Cools, Jan

“…Leukemia is caused by the accumulation of multiple genomic lesions in hematopoietic precursor cells. However, how these events cooperate during oncogenic…”
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General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL by Fazi, Claudia, Scarfò, Lydia, Pecciarini, Lorenza, Cottini, Francesca, Dagklis, Antonis, Janus, Agnieszka, Talarico, Anna, Scielzo, Cristina, Sala, Cinzia, Toniolo, Daniela, Caligaris-Cappio, Federico, Ghia, Paolo

“…Monoclonal B-cell lymphocytosis (MBL) is classified as chronic lymphocytic leukemia (CLL)–like, atypical CLL, and CD5− MBL. The number of B cells per…”
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Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors by Dagklis, Antonis, Demeyer, Sofie, De Bie, Jolien, Radaelli, Enrico, Pauwels, Daphnie, Degryse, Sandrine, Gielen, Olga, Vicente, Carmen, Vandepoel, Roel, Geerdens, Ellen, Uyttebroeck, Anne, Boeckx, Nancy, de Bock, Charles E., Cools, Jan

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive childhood leukemia that is caused by the accumulation of multiple genomic lesions resulting in…”
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Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL by Vardi, Anna, Dagklis, Antonis, Scarfò, Lydia, Jelinek, Diane, Newton, Darren, Bennett, Fiona, Almeida, Julia, Rodriguez-Caballero, Arancha, Allgood, Sallie, Lanasa, Mark, Cortelezzi, Agostino, Orlandi, Ester, Veronese, Silvio, Montillo, Marco, Rawstron, Andy, Shanafelt, Tait, Orfao, Alberto, Stamatopoulos, Kostas, Ghia, Paolo

“…Chronic lymphocytic leukemia (CLL) –like monoclonal B-cell lymphocytosis (MBL) shares common immunophenotype and cytogenetic abnormalities with CLL, from which…”
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CLL-like monoclonal B-cell lymphocytosis: Are we all bound to have it? by Scarfò, Lydia, Dagklis, Antonis, Scielzo, Cristina, Fazi, Claudia, Ghia, Paolo

“…Abstract CLL-like monoclonal B-cell lymphocytosis (MBL) shares a unique immunophenotype with chronic lymphocytic leukemia (CLL), and represents the vast…”
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Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases by Hadzidimitriou, Anastasia, Agathangelidis, Andreas, Darzentas, Nikos, Murray, Fiona, Delfau-Larue, Marie-Helene, Pedersen, Lone Bredo, Lopez, Alba Navarro, Dagklis, Antonis, Rombout, Paul, Beldjord, Kheira, Kolstad, Arne, Dreyling, Martin H., Anagnostopoulos, Achilles, Tsaftaris, Athanasios, Mavragani-Tsipidou, Penelope, Rosenwald, Andreas, Ponzoni, Maurilio, Groenen, Patricia, Ghia, Paolo, Sander, Birgitta, Papadaki, Theodora, Campo, Elias, Geisler, Christian, Rosenquist, Richard, Davi, Frederic, Pott, Christiane, Stamatopoulos, Kostas

“…We examined 807 productive IGHV-IGHD-IGHJ gene rearrangements from mantle cell lymphoma (MCL) cases, by far the largest series to date. The IGHV gene…”
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Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology? by Ponzoni, Maurilio, Kanellis, George, Pouliou, Evi, Baliakas, Panagiotis, Scarfò, Lydia, Ferreri, Andrés J M, Doglioni, Claudio, Bikos, Vasilis, Dagklis, Antonis, Anagnostopoulos, Achilles, Ghia, Paolo, Stamatopoulos, Kostas, Papadaki, Theodora

“…Primary splenic small B-cell lymphomas mostly comprise the distinct entity of splenic marginal-zone lymphoma (SMZL) and the provisional category of splenic…”
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Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models by Bertilaccio, Maria Teresa Sabrina, Simonetti, Giorgia, Dagklis, Antonis, Rocchi, Martina, Rodriguez, Tania Veliz, Apollonio, Benedetta, Mantovani, Alberto, Ponzoni, Maurilio, Ghia, Paolo, Garlanda, Cecilia, Caligaris-Cappio, Federico, Muzio, Marta

“…Inflammation is involved in the initiation and progression of several chronic lymphoid malignancies of B-cell type. Toll-like receptors (TLR) are transmembrane…”
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Abstract LB-210: KPT-8602 is a second-generation XPO1 inhibitor with improved in vivo tolerability that demonstrates potent acute lymphoblastic leukemia activity by Daelemans, Dirk, Neggers, Jasper Edgar, De Bie, Jolien, Jacquemyn, Maarten, D’Hoore, Astrid, Vanstreels, Els, Baloglu, Erkan, Landesman, Yosef, Shacham, Sharon, Senapedis, William, Dagklis, Antonis, Vercruysse, Thomas, Cools, Jan

“…Abstract Human exportin-1 (XPO1) is the key nuclear-cytoplasmic transport protein that exports a wide variety of different cargo proteins including tumor…”
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Monoclonal B cell lymphocytosis in hepatitis C virus infected individuals by Fazi, Claudia, Dagklis, Antonis, Cottini, Francesca, Scarfò, Lydia, Bertilaccio, Maria Teresa Sabrina, Finazzi, Renato, Memoli, Massimo, Ghia, Paolo

“…Background: Monoclonal B cell lymphocytosis (MBL) is a preclinical condition characterized by an expansion of clonal B cells in the absence of B lymphocytosis…”
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Bertilaccio MT, Simonetti G, Dagklis A, et al. Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models. Blood. 2011;118(3):660–669 by Bertilaccio, Maria Teresa Sabrina, Simonetti, Giorgia, Dagklis, Antonis, Rocchi, Martina, Rodriguez, Tania Veliz, Apollonio, Benedetta, Mantovani, Alberto, Ponzoni, Maurilio, Ghia, Paolo, Garlanda, Cecilia, Caligaris-Cappio, Federico, Muzio, Marta

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