Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors

Complex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating neuronal activity must be adapted to fit into such paradigms. Here, we present a head-mounted, magnetically activated device for wireless optogenetic manip...

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Bibliographic Details
Published in:	Neuron (Cambridge, Mass.) Vol. 107; no. 4; pp. 644 - 655.e7
Main Authors:	Anpilov, Sergey, Shemesh, Yair, Eren, Noa, Harony-Nicolas, Hala, Benjamin, Asaf, Dine, Julien, Oliveira, Vinícius E.M., Forkosh, Oren, Karamihalev, Stoyo, Hüttl, Rosa-Eva, Feldman, Noa, Berger, Ryan, Dagan, Avi, Chen, Gal, Neumann, Inga D., Wagner, Shlomo, Yizhar, Ofer, Chen, Alon
Format:	Journal Article Web Resource
Language:	English
Published:	United States Elsevier Inc 19-08-2020 Elsevier Limited Cell Press
Subjects:	aggression Agonistic Behavior - physiology Anatomie (cytologie, histologie, embryologie...) & physiologie Anatomy (cytology, histology, embryology...) & physiology Animals Behavior Behavior, Animal - physiology Brain Dental cement Life sciences Light emitting diodes Mice Nervous system Neuromodulation Neurons - metabolism Neurons - physiology Neurons/metabolism/physiology Optics optogenetics Optogenetics - methods Oxytocin Oxytocin - metabolism Phenotyping Power supply Sciences du vivant Social Behavior social salience wireless Wireless Technology oxytocin social salience wireless aggression social behavior optogenetics
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Summary:	Complex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating neuronal activity must be adapted to fit into such paradigms. Here, we present a head-mounted, magnetically activated device for wireless optogenetic manipulation that is compact, simple to construct, and suitable for use in group-living mice in an enriched semi-natural arena over several days. Using this device, we demonstrate that repeated activation of oxytocin neurons in male mice can have different effects on pro-social and agonistic behaviors, depending on the social context. Our findings support the social salience hypothesis of oxytocin and emphasize the importance of the environment in the study of social neuromodulators. Our wireless optogenetic device can be easily adapted for use in a variety of behavioral paradigms, which are normally hindered by tethered light delivery or a limited environment. [Display omitted] •A small, wireless device is used for optogenetic activation in a complex environment•PVN oxytocin neurons were activated repeatedly over 2 days in a group setting•Repeated activation in a group setting elicited both pro-social and agonistic behavior•Findings support the social salience hypothesis of oxytocin neuro-modulation Anpilov et al. present a lightweight, easily assembled wireless optogenetic device compatible with group-housed mice in a complex environment. Using this approach, they show that repeated activation of oxytocin neurons elicits both pro-social and aggressive behaviors over time, emphasizing the role of the social setting in modulating behavior.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 scopus-id:2-s2.0-85089380100 Lead Contact These authors contributed equally
ISSN:	0896-6273 1097-4199 1097-4199
DOI:	10.1016/j.neuron.2020.05.028