Search Results - "Daga, Rafael R."
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MAPK-dependent control of mitotic progression in S. pombe
Published in BMC biology (25-03-2024)“…Mitogen-activated protein kinases (MAPKs) preserve cell homeostasis by transducing physicochemical fluctuations of the environment into multiple adaptive…”
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2
Formation of Transient Protein Aggregate-like Centers Is a General Strategy Postponing Degradation of Misfolded Intermediates
Published in International journal of molecular sciences (01-07-2023)“…When misfolded intermediates accumulate during heat shock, the protein quality control system promotes cellular adaptation strategies. In , thermo-sensitive…”
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3
The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components
Published in The Journal of cell biology (06-11-2017)“…Kinetochores (KTs) are large multiprotein complexes that constitute the interface between centromeric chromatin and the mitotic spindle during chromosome…”
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4
Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast
Published in Cell reports (Cambridge) (24-04-2018)“…In metazoans, the nuclear envelope (NE) breakdown (NEBD) occurs during “open” mitosis and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis…”
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5
Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity
Published in iScience (15-11-2024)“…In addition to the degradation of cell-cycle proteins, short-lived, damaged, or unfolded proteins are constantly cleared from cells by the proteasome. During…”
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6
Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly
Published in The Journal of cell biology (11-05-2015)“…During each cell cycle, the mitotic spindle is efficiently assembled to achieve chromosome segregation and then rapidly disassembled as cells enter…”
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7
Dynamic positioning of the fission yeast cell division plane
Published in Proceedings of the National Academy of Sciences - PNAS (07-06-2005)“…A key question in cytokinesis is how the cell division plane is positioned. Whereas microtubules of the mitotic apparatus specify the division site in animal…”
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8
Lallzyme MMX‐based rapid method for fission yeast protoplast preparation
Published in Yeast (Chichester, England) (01-02-2014)“…Fungal cells including yeasts are surrounded by cell wall that counteracts turgor pressure and prevents cell lysis. Many yeast experiments, including genetic…”
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9
Nuclear Mechanics in the Fission Yeast
Published in Cells (Basel, Switzerland) (20-10-2019)“…In eukaryotic cells, the organization of the genome within the nucleus requires the nuclear envelope (NE) and its associated proteins. The nucleus is subjected…”
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10
A new role for the nuclear basket network
Published in Microbial cell (27-11-2017)“…Our view of the nuclear pore complexes (NPCs) as gateways between the nuclear and cytoplasmic compartments has been largely expanded in recent years. NPCs have…”
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11
Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast
Published in Genetics (Austin) (01-12-2010)“…In Schizosaccharomyces pombe, Etd1 is a positive regulator of the septation initiation network (SIN), a conserved GTPase-regulated kinase cascade that triggers…”
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12
Self-organization of microtubule bundles in anucleate fission yeast cells
Published in Nature cell biology (01-10-2006)“…Self-organization of cellular structures is an emerging principle underlying cellular architecture. Properties of dynamic microtubules and microtubule-binding…”
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13
Regulation of fission yeast morphogenesis by PP2A activator pta2
Published in PloS one (05-03-2012)“…Cell polarization is key for the function of most eukaryotic cells, and regulates cell shape, migration and tissue architecture. Fission yeast,…”
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14
Spatiotemporal control of spindle disassembly in fission yeast
Published in Cellular and molecular life sciences : CMLS (01-09-2019)“…Maintenance of genomic stability during cell division is one of the most important cellular tasks, and it critically depends on the faithful replication of the…”
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15
Yeast as a biosensor of detoxification: a tool for identifying new compounds that revert multidrug resistance
Published in Current drug targets (01-08-2013)“…During tumour progression, cells accumulate secondary mutations and/or chromosomal aberrations that generate genetic diversity within the tumour cell…”
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16
Reversible protein aggregation as cytoprotective mechanism against heat stress
Published in Current genetics (01-12-2021)“…Temperature fluctuation is one of the most frequent threats to which organisms are exposed in nature. The activation of gene expression programs that trigger…”
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17
Cell migration and division in amoeboid-like fission yeast
Published in Biology open (15-01-2014)“…Yeast cells are non-motile and are encased in a cell wall that supports high internal turgor pressure. The cell wall is also essential for cellular…”
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18
Acute Heat Stress Leads to Reversible Aggregation of Nuclear Proteins into Nucleolar Rings in Fission Yeast
Published in Cell reports (Cambridge) (10-11-2020)“…Upon acute heat stress (HS), overall mRNA transcription, processing, and export are inhibited, leading to cell growth arrest. However, how cells turn off mRNA…”
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19
Selective Nuclear Pore Complex Removal Drives Nuclear Envelope Division in Fission Yeast
Published in Current biology (17-08-2020)“…An important question in cell biology is how cellular organelles partition during cell division. In organisms undergoing closed mitosis, the elongation of an…”
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20
Intra-nuclear microtubules and a mitotic spindle orientation checkpoint
Published in Nature cell biology (01-12-2004)“…Cells of the fission yeast Schizosaccharomyces pombe have a checkpoint mechanism that reportedly monitors the orientation of the mitotic spindle. Astral…”
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