Search Results - "Dafydd G. Thomas"

Silencing of Long Noncoding RNA MIR22HG Triggers Cell Survival/Death Signaling via Oncogenes YBX1, MET, and p21 in Lung Cancer by Su, Wenmei, Feng, Shumei, Chen, Xiuyuan, Yang, Xia, Mao, Rui, Guo, Chunfang, Wang, Zhuwen, Thomas, Dafydd G, Lin, Jules, Reddy, Rishindra M, Orringer, Mark B, Chang, Andrew C, Yang, Zhixiong, Beer, David G, Chen, Guoan

“…The long noncoding RNA (lncRNA) has previously been identified as a prognostic marker in hepatocellular carcinoma. Here, we performed a comprehensive analysis…”
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EWSR1-NFATC2 Translocation-associated Sarcoma Clinicopathologic Findings in a Rare Aggressive Primary Bone or Soft Tissue Tumor by Wang, Grace Y, Thomas, Dafydd G, Davis, Jessica L, Ng, Tony, Patel, Rajiv M, Harms, Paul W, Betz, Bryan L, Schuetze, Scott M, McHugh, Jonathan B, Horvai, Andrew E, Cho, Soo-Jin, Lucas, David R

“…In recent years, a novel small round cell sarcoma harboring EWSR1-NFATC2 translocation with immunomorphologic overlap with Ewing sarcoma (ES), myoepithelial…”
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TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination by Chandler, Benjamin C, Moubadder, Leah, Ritter, Cassandra L, Liu, Meilan, Cameron, Meleah, Wilder-Romans, Kari, Zhang, Amanda, Pesch, Andrea M, Michmerhuizen, Anna R, Hirsh, Nicole, Androsiglio, Marlie, Ward, Tanner, Olsen, Eric, Niknafs, Yashar S, Merajver, Sofia, Thomas, Dafydd G, Brown, Powel H, Lawrence, Theodore S, Nyati, Shyam, Pierce, Lori J, Chinnaiyan, Arul, Speers, Corey

“…Increased rates of locoregional recurrence are observed in patients with basal-like breast cancer (BC) despite the use of radiation therapy (RT); therefore,…”
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Molecular Classification and Prognostication of Adrenocortical Tumors by Transcriptome Profiling by GIORDANO, Thomas J, KUICK, Rork, ELSE, Tobias, GAUGER, Paul G, VINCO, Michelle, BAUERSFELD, Juliane, SANDERS, Donita, THOMAS, Dafydd G, DOHERTY, Gerard, HAMMER, Gary

“…Purpose: Our understanding of adrenocortical carcinoma (ACC) has improved considerably, yet many unanswered questions remain. For instance, can molecular…”
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PD-L1 expression on circulating tumor cells and platelets in patients with metastatic breast cancer by Darga, Elizabeth P, Dolce, Emily M, Fang, Fang, Kidwell, Kelley M, Gersch, Christina L, Kregel, Steven, Thomas, Dafydd G, Gill, Anoop, Brown, Martha E, Gross, Steven, Connelly, Mark, Holinstat, Michael, Cobain, Erin F, Rae, James M, Hayes, Daniel F, Paoletti, Costanza

“…Immune checkpoint inhibition is effective in several cancers. Expression of programmed death-ligand 1 (PD-L1) on circulating tumor or immune effector cells…”
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Identifying an ovarian cancer cell hierarchy regulated by bone morphogenetic protein 2 by Choi, Yun-Jung, Ingram, Patrick N., Yang, Kun, Coffman, Lan, Iyengar, Mangala, Bai, Shoumei, Thomas, Dafydd G., Yoon, Euisik, Buckanovich, Ronald J.

“…Whether human cancer follows a hierarchical or stochastic model of differentiation is controversial. Furthermore, the factors that regulate cancer stem-like…”
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HER2 Drives Luminal Breast Cancer Stem Cells in the Absence of HER2 Amplification: Implications for Efficacy of Adjuvant Trastuzumab by ITHIMAKIN, Suthinee, DAY, Kathleen C, HALL, Christopher L, PALANISAMY, Nallasivam, HEATH, Amber N, TAWAKKOL, Nader, LUTHER, Tahra K, CLOUTHIER, Shawn G, CHADWICK, Whitney A, DAY, Mark L, KLEER, Celina G, THOMAS, Dafydd G, MALIK, Fayaz, HAYES, Daniel F, KORKAYA, Hasan, WICHA, Max S, QIN ZEN, DAWSEY, Scott J, BERSANO-BEGEY, Tom F, QURAISHI, Ahmed A, IGNATOSKI, Kathleen Woods, DAIGNAULT, Stephanie, DAVIS, April

“…Although current breast cancer treatment guidelines limit the use of HER2-blocking agents to tumors with HER2 gene amplification, recent retrospective analyses…”
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Transcriptome Profiling Identifies HMGA2 as a Biomarker of Melanoma Progression and Prognosis by Raskin, Leon, Fullen, Douglas R., Giordano, Thomas J., Thomas, Dafydd G., Frohm, Marcus L., Cha, Kelly B., Ahn, Jaeil, Mukherjee, Bhramar, Johnson, Timothy M., Gruber, Stephen B.

“…The genetic alterations contributing to melanoma pathogenesis are incompletely defined, and few independent prognostic features have been identified beyond the…”
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Efficacy of Imatinib in Aggressive Fibromatosis: Results of a Phase II Multicenter Sarcoma Alliance for Research through Collaboration (SARC) Trial by CHUGH, Rashmi, WATHEN, J. Kyle, BENJAMIN, Robert S, BAKER, Laurence H, PATEL, Shreyaskumar R, MAKI, Robert G, MEYERS, Paul A, SCHUETZE, Scott M, PRIEBAT, Dennis A, THOMAS, Dafydd G, JACOBSON, Jon A, SAMUELS, Brian L

“…Aggressive fibromatoses (AF; desmoid tumors) are rare clonal neoplastic proliferations of connective tissues that can be locally aggressive despite wide…”
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BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation by Lewis, Valerae O., Devarajan, Eswaran, Cardó-Vila, Marina, Thomas, Dafydd G., Kleinerman, Eugenie S., Marchiò, Serena, Sidman, Richard L., Pasqualini, Renata, Arap, Wadih

“…Osteosarcoma occurs predominantly in children and young adults. High-grade tumors require multidisciplinary treatment consisting of chemotherapy in the…”
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Myeloid-Derived Suppressor Cells Enhance Stemness of Cancer Cells by Inducing MicroRNA101 and Suppressing the Corepressor CtBP2 by Cui, Tracy X., Kryczek, Ilona, Zhao, Lili, Zhao, Ende, Kuick, Rork, Roh, Michael H., Vatan, Linda, Szeliga, Wojciech, Mao, Yujun, Thomas, Dafydd G., Kotarski, Jan, Tarkowski, Rafał, Wicha, Max, Cho, Kathleen, Giordano, Thomas, Liu, Rebecca, Zou, Weiping

“…Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer…”
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Significance of Circulating Tumor Cells in Metastatic Triple-Negative Breast Cancer Patients within a Randomized, Phase II Trial: TBCRC 019 by Paoletti, Costanza, Li, Yufeng, Muñiz, Maria C, Kidwell, Kelley M, Aung, Kimberly, Thomas, Dafydd G, Brown, Martha E, Abramson, Vandana G, Irvin, Jr, William J, Lin, Nancy U, Liu, Minetta C, Nanda, Rita, Nangia, Julie R, Storniolo, Anna M, Traina, Tiffany A, Vaklavas, Christos, Van Poznak, Catherine H, Wolff, Antonio C, Forero-Torres, Andres, Hayes, Daniel F

“…Circulating tumor cells (CTC) are prognostic in metastatic breast cancer (MBC). We tested whether EpCAM-based capture system (CellSearch) is effective in…”
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Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical Model by CHUGH, Rashmi, KYLE WATHEN, J, SAMUELS, Brian L, BAKER, Laurence H, MAKI, Robert G, BENJAMIN, Robert S, PATEL, Shreyaskumar R, MYERS, Paul A, PRIEBAT, Dennis A, REINKE, Denise K, THOMAS, Dafydd G, KEOHAN, Mary L

“…PURPOSE The purpose of this trial was to assess the efficacy of imatinib in patients with one of 10 different subtypes of advanced sarcoma. PATIENTS AND…”
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Comparative analysis of rosacea and cutaneous lupus erythematosus: Histopathologic features, T-cell subsets, and plasmacytoid dendritic cells by Brown, Theodore T., MD, Choi, Eun-Young K., MD, Thomas, Dafydd G., MD, PhD, Hristov, Alexandra C., MD, Chan, May P., MD

“…Background Distinction of rosacea and cutaneous lupus erythematosus (LE) can be challenging because of significant clinical and histologic overlap. A…”
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Preclinical Targeting of the Type I Insulin-Like Growth Factor Receptor in Adrenocortical Carcinoma by Barlaskar, Ferdous M., Spalding, Aaron C., Heaton, Joanne H., Kuick, Rork, Kim, Alex C., Thomas, Dafydd G., Giordano, Thomas J., Ben-Josef, Edgar, Hammer, Gary D.

“…Context: Drug therapy for adrenocortical carcinoma (ACC), a rare and lethal malignancy, is largely empirical and ineffective. New treatments directed at…”
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Distinct Gene Expression Profiles of Viral- and Nonviral-Associated Merkel Cell Carcinoma Revealed by Transcriptome Analysis by Harms, Paul W., Patel, Rajiv M., Verhaegen, Monique E., Giordano, Thomas J., Nash, Kevin T., Johnson, Craig N., Daignault, Stephanie, Thomas, Dafydd G., Gudjonsson, Johann E., Elder, James T., Dlugosz, Andrzej A., Johnson, Timothy M., Fullen, Douglas R., Bichakjian, Christopher K.

“…Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine tumor with high mortality rates. Merkel cell polyomavirus (MCPyV), identified in the…”
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Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma by Krook, Melanie A, Nicholls, Lauren A, Scannell, Christopher A, Chugh, Rashmi, Thomas, Dafydd G, Lawlor, Elizabeth R

“…Ewing sarcoma is the second most common bone cancer in pediatric patients. Although the primary cause of death in Ewing sarcoma is metastasis, the mechanism…”
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The role of Dickkopf-3 overexpression in esophageal adenocarcinoma by Wang, Zhuwen, MS, Lin, Lin, MD, PhD, Thomas, Dafydd G., MD, Nadal, Ernest, MD, Chang, Andrew C., MD, Beer, David G., PhD, Lin, Jules, MD

“…Abstract Objectives Ninety percent of patients with esophageal adenocarcinoma ultimately die of their disease, highlighting the need for novel therapeutic…”
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Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma by McKenna, Mary K, Ozcan, Ada, Brenner, Daniel, Watanabe, Norihiro, Legendre, Maureen, Thomas, Dafydd G, Ashwood, Christopher, Cummings, Richard D, Bonifant, Challice, Markovitz, David M, Brenner, Malcolm K

“…BackgroundCell therapies for solid tumors are thwarted by the hostile tumor microenvironment (TME) and by heterogeneous expression of tumor target antigens. We…”
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Osteopontin (OPN/SPP1) isoforms collectively enhance tumor cell invasion and dissemination in esophageal adenocarcinoma by Lin, Jules, Myers, Amy L, Wang, Zhuwen, Nancarrow, Derek J, Ferrer-Torres, Daysha, Handlogten, Amy, Leverenz, Kimmy, Bao, Julia, Thomas, Dafydd G, Wang, Thomas D, Orringer, Mark B, Reddy, Rishindra M, Chang, Andrew C, Beer, David G, Lin, Lin

“…Esophageal adenocarcinoma (EAC) is often diagnosed at an advanced stage, thus understanding the molecular basis for EAC invasion and metastasis is critical…”
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