Search Results - "Dafré, Alcir Luiz"
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Protective effects of diphenyl diselenide in a mouse model of brain toxicity
Published in Chemico-biological interactions (25-10-2013)“…•The electron transfer chain is a sensitive target of MeHg toxicity.•MeHg-induced mitochondrial dysfunction could be prevented if (PhSe)2 is…”
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Protective effects of Polygala paniculata extract against methylmercury-induced neurotoxicity in mice
Published in Journal of pharmacy and pharmacology (01-11-2005)“…We have examined the possible protective effects of Polygala paniculata extract against methylmercury (MeHg)‐induced neurotoxicity in adult mice. MeHg was…”
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Dietary supplementation with increasing doses of an organic micromineral complex on juvenile Nile tilapia: Effects on the antioxidant defense system and tissue deposition
Published in Comparative biochemistry and physiology. Part A, Molecular & integrative physiology (01-10-2021)“…The effect of increasing amounts (0%, 25%, 50%, 75%, and 100%) of dietary supplementation with an organic micromineral complex (Fe, Zn, Cu, Mn, and Se) on…”
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Transcriptional effects in the estuarine guppy Poecilia vivipara exposed to sanitary sewage in laboratory and in situ
Published in Ecotoxicology and environmental safety (30-10-2019)“…The urban growth has increased sanitary sewage discharges in coastal ecosystems, negatively affecting the aquatic biota. Mangroves, one of the most…”
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Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice
Published in Neurotoxicology (Park Forest South) (01-12-2011)“…► The oximes pralidoxime and K074 were administered 6 h after the malathion exposure. ► Malathion decreased the cortico-cerebral, hippocampal and blood AChE…”
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Antioxidant deficit in gills of Pacific oyster ( Crassostrea gigas) exposed to chlorodinitrobenzene increases menadione toxicity
Published in Aquatic toxicology (01-02-2012)“…Disturbances in antioxidant defenses decrease cellular protection against oxidative stress and jeopardize cellular homeostasis. To knock down the antioxidant…”
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Repeated Methylglyoxal Treatment Depletes Dopamine in the Prefrontal Cortex, and Causes Memory Impairment and Depressive-Like Behavior in Mice
Published in Neurochemical research (01-02-2020)“…Methylglyoxal (MGO) is a highly reactive dicarbonyl molecule that promotes the formation of advanced glycation end products (AGEs), which are believed to play…”
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Exploring Capsaicin and Cinnamaldehyde for Scratching Behaviour in Mice: Effects of Sex, Concentration and Time Course
Published in Acta dermato-venereologica (13-06-2023)“…Abstract is missing (Short communication)…”
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Multiple cellular targets involved in the antidepressant-like effect of glutathione
Published in Chemico-biological interactions (01-09-2020)“…A previous study demonstrated that glutathione (GSH) produces specific antidepressant-like effect in the forced swimming test (FST), a predictive test of…”
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Glutathione in Chlorpyrifos-and Chlorpyrifos-Oxon-Induced Toxicity: a Comparative Study Focused on Non-cholinergic Toxicity in HT22 Cells
Published in Neurotoxicity research (01-10-2020)“…Chlorpyrifos (CPF) is a neurotoxic organophosphorus (OP) insecticide widely used for agricultural purposes. CPF-mediated neurotoxicity is mainly associated…”
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Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington's Disease Effects in YAC128 Mice
Published in International journal of molecular sciences (01-08-2023)“…Huntington's disease (HD) is a neurodegenerative genetic disorder characterized by motor, psychiatric, cognitive, and peripheral symptoms without effective…”
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Diphenyl diselenide protects neuronal cells against oxidative stress and mitochondrial dysfunction: Involvement of the glutathione-dependent antioxidant system
Published in Redox biology (01-01-2019)“…Oxidative stress and mitochondrial dysfunction are critical events in neurodegenerative diseases; therefore, molecules that increase cellular antioxidant…”
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Methylglyoxal-Mediated Dopamine Depletion, Working Memory Deficit, and Depression-Like Behavior Are Prevented by a Dopamine/Noradrenaline Reuptake Inhibitor
Published in Molecular neurobiology (01-02-2021)“…Methylglyoxal (MGO) is an endogenous toxin, mainly produced as a by-product of glycolysis that has been associated to aging, Alzheimer’s disease, and…”
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Zinc causes acute impairment of glutathione metabolism followed by coordinated antioxidant defenses amplification in gills of brown mussels Perna perna
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01-01-2014)“…Zinc demonstrates protective and antioxidant properties at physiological levels, although these characteristics are not attributed at moderate or high…”
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The biological importance of glutathione peroxidase and peroxiredoxin backup systems in bivalves during peroxide exposure
Published in Marine environmental research (01-10-2014)“…Organic peroxide elimination in eukaryotes essentially depends on glutathione peroxidase (GPx) and peroxiredoxin (Prx) enzymes, which are supported by their…”
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Selenium in water enhances antioxidant defenses and protects against copper-induced DNA damage in the blue mussel Mytilus edulis
Published in Aquatic toxicology (17-01-2011)“…Selenium and copper are naturally occurring elements in the environment that have important roles in cellular function. Selenium is known for its role in…”
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Pulmonary and muscle profile in pneumosepsis: A temporal analysis of inflammatory markers
Published in Cytokine (Philadelphia, Pa.) (01-02-2019)“…•Pneumosepsis decreased significantly the physical performance of mice.•Pneumosepsis resulted in an increase in cell influx and cytokines levels in the…”
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Cellular and transcriptional responses of Crassostrea gigas hemocytes exposed in vitro to brevetoxin (PbTx-2)
Published in Marine drugs (01-03-2012)“…Hemocytes mediate a series of immune reactions essential for bivalve survival in the environment, however, the impact of harmful algal species and their…”
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Antioxidant defenses, longevity and ecophysiology of South American bats
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01-07-2007)“…Microchiropteran bats sustain very high oxygen consumption rates when active, but they also exhibit drastic daily drops in oxygen consumption when torpid. In…”
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Luteinizing Hormone and Testosterone Levels during Acute Phase of Severe Traumatic Brain Injury: Prognostic Implications for Adult Male Patients
Published in Frontiers in endocrinology (Lausanne) (13-02-2018)“…Traumatic brain injury (TBI) is a worldwide core public health problem affecting mostly young male subjects. An alarming increase in incidence has turned TBI…”
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