Search Results - "Dafny, Nachum"
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Differential Roles of Key Brain Regions: Ventral Tegmental Area, Locus Coeruleus, Dorsal Raphe, Nucleus Accumbens, Caudate Nucleus, and Prefrontal Cortex in Regulating Response to Methylphenidate: Insights from Neuronal and Behavioral Studies in Freely Behaving Rats
Published in International journal of molecular sciences (01-06-2024)“…A total of 3102 neurons were recorded before and following acute and chronic methylphenidate (MPD) administration. Acute MPD exposure elicits mainly increases…”
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Differential Impact of Serotonin Signaling Methylphenidate on Young versus Adult: Insights from Behavioral and Dorsal Raphe Nucleus Neuronal Recordings from Freely Behaving Rats
Published in International journal of molecular sciences (01-08-2024)“…Methylphenidate (MPD) remains a cornerstone pharmacological intervention for managing ADHD, yet its increasing usage among ordinary youth and adults outside…”
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Dopamine, Norepinephrine and Serotonin Participate Differently in Methylphenidate Action in Concomitant Behavioral and Ventral Tegmental Area, Locus Coeruleus and Dorsal Raphe Neuronal Study in Young Rats
Published in International journal of molecular sciences (01-12-2023)“…Methylphenidate (MPD), known as Ritalin, is a psychostimulant used to treat children, adults, and the elderly. MPD exerts its effects through increasing…”
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Dose response effect of methylphenidate on ventral tegmental area neurons and animal behavior
Published in Brain research bulletin (01-07-2013)“…Highlights • 89% (154/173) VTA units responded; 66% (101/154) increased their firing rate. • 92% (48/52) VTA units responded to 0.6 mg/kg; 58% (28/48)…”
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Methylphenidate modulates dorsal raphe neuronal activity: behavioral and neuronal recordings from adolescent rats
Published in Brain research bulletin (01-01-2017)“…Highlights • The same MPD dose elicits either behavioral tolerance or sensitization. • MPD elicits a dose dependent effect on DR neuronal activity. • DR…”
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Dose-response characteristics of methylphenidate on locomotor behavior and on sensory evoked potentials recorded from the VTA, NAc, and PFC in freely behaving rats
Published in Behavioral and brain functions (17-01-2006)“…Methylphenidate (MPD) is a psychostimulant commonly prescribed for attention deficit/hyperactivity disorder. The mode of action of the brain circuitry…”
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Acute and chronic dose–response effect of methylphenidate on ventral tegmental area neurons correlated with animal behavior
Published in Journal of Neural Transmission (01-03-2014)“…Methylphenidate (MPD) is used to treat ADHD and as a cognitive enhancement and recreationally. MPD’s effects are not fully understood. One of the sites of…”
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Methylphenidate cross-sensitization with amphetamine is dose dependent but not age dependent
Published in Behavioural brain research (13-02-2023)“…Psychostimulants such as methylphenidate (MPD) and amphetamine (AMP) are often prescribed to young children and adolescents to treat behavioral disorders, or…”
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Methylphenidate induces a different response in the dorsal raphe as compared to ventral tegmental area and locus coeruleus: behavioral and concomitant neuronal recordings in adult rats
Published in Journal of Neural Transmission (01-12-2023)“…Methylphenidate (MPD) is a psychostimulant used to treat attention deficit hyperactivity disorder. MPD exerts its neurocognitive effects through increasing…”
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The effect of environment on cross-sensitization between methylphenidate and amphetamine in female rats
Published in Physiology & behavior (01-08-2022)“…•Drug injection and recording were done in two different environments: the home cage with two cow bones for enrichment and test cage. Animals of the home cage…”
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Chronic exposure to MDMA (Ecstasy) elicits behavioral sensitization in rats but fails to induce cross-sensitization to other psychostimulants
Published in Behavioral and brain functions (04-01-2006)“…The recreational use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) among adolescents and young adults has become increasingly prevalent in recent years…”
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Behavioral and dorsal raphe neuronal activity following acute and chronic methylphenidate in freely behaving rats
Published in Brain research bulletin (01-09-2013)“…Highlights • Concomitant behavioral and DR neuronal activity were recorded following acute and chronic MPD in freely moving rats. • The same dose of chronic…”
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Acute and chronic methylphenidate modulates the neuronal activity of the caudate nucleus recorded from freely behaving rats
Published in Brain research bulletin (10-03-2012)“…Highlights ► All CN units respond to acute and chronic MPD exposure. ► 70% of CN units increased activity following initial MPD exposure. ► 72% of CN units…”
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Methylphenidate modulates the locus ceruleus neuronal activity in freely behaving rat
Published in European journal of pharmacology (15-11-2012)“…The electrophysiological properties of the locus coeruleus (LC) neurons in response to acute and chronic administration of methylphenidate (MPD) were…”
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Glutamate and dopamine in the VTA participate differently in the acute and chronic effect of methylphenidate
Published in Behavioural brain research (17-02-2020)“…Psychostimulants such as methylphenidate (MPD) have long been the treatment of choice in behavioral disorders such as attention deficit/hyperactivity disorder…”
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Dorsal raphe neuronal activities are modulated by methylphenidate
Published in Journal of Neural Transmission (01-05-2013)“…This study investigated the electrophysiological properties of the dorsal raphe nucleus (DR) neurons in response to the acute and repetitive administration of…”
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Chronic methylphenidate elicits long-term effects in adolescent female WKY rats
Published in Drug and alcohol dependence (01-07-2014)Get full text
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Methylphenidate dose response characteristics of caudate nucleus neuronal activity correlated with animal behavior
Published in Drug and alcohol dependence (01-07-2014)Get full text
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Glutaminergic signaling in the caudate nucleus is required for behavioral sensitization to methylphenidate
Published in Pharmacology, biochemistry and behavior (01-09-2019)“…Methylphenidate (MPD) is a widely prescribed psychostimulant for the treatment of attention deficit hyperactivity disorder, and is growing in use as a…”
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