Search Results - "Daeyaert, Frederik"

SYNOPSIS:  SYNthesize and OPtimize System in Silico by Vinkers, H. Maarten, de Jonge, Marc R, Daeyaert, Frederik F. D, Heeres, Jan, Koymans, Lucien M. H, van Lenthe, Joop H, Lewi, Paul J, Timmerman, Henk, Van Aken, Koen, Janssen, Paul A. J

“…We present a de novo design program called SYNOPSIS, that includes a synthesis route for each generated molecule. SYNOPSIS designs novel molecules by starting…”
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Evolution of anti-HIV drug candidates. Part 3: diarylpyrimidine (DAPY) analogues by Ludovici, Donald W., De Corte, Bart L., Kukla, Michael J., Ye, Hong, Ho, Chih Y., Lichtenstein, Mark A., Kavash, Robert W., Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, Lewi, Paul J., Heeres, Jan, Koymans, Lucien M.H., de Jonge, Marc R., Van Aken, Koen J.A., Daeyaert, Frederik F.D., Das, Kalyan, Arnold, Edward, Janssen, Paul A.J.

“…The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Several members of this novel class of non-nucleoside reverse…”
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Evolution of anti-HIV drug candidates. Part 2 : Diaryltriazine (DATA) analogues by LUDOVICI, Donald W, KAVASH, Robert W, MOEREELS, Henry E. L, HEERES, Jan, KOYMANS, Lucien M. H, DE JONGE, Marc R, VAN AKEN, Koen J. A, DAEYAERT, Frederik F. D, LEWI, Paul J, DAS, Kalyan, ARNOLD, Edward, JANSSEN, Paul A. J, KUKLA, Michael J, HO, Chih Y, HONG YE, DE CORTE, Bart L, ANDRIES, Koen, DE BETHUNE, Marie-Pierre, AZIJN, Hilde, PAUWELS, Rudi

“…A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the…”
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Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants by Das, Kalyan, Clark, Arthur D, Lewi, Paul J, Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Vinkers, H. Maarten, Daeyaert, Frederik, Ludovici, Donald W, Kukla, Michael J, De Corte, Bart, Kavash, Robert W, Ho, Chih Y, Ye, Hong, Lichtenstein, Mark. A, Andries, Koen, Pauwels, Rudi, de Béthune, Marie-Pierre, Boyer, Paul L, Clark, Patrick, Hughes, Stephen H, Janssen, Paul A. J, Arnold, Eddy

“…Anti-AIDS drug candidate and non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC125-R165335 (etravirine) caused an initial drop in viral load similar to…”
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Evolution of Anti-HIV Drug CandidatesPart 2: Diaryltriazine (DATA) Analogues by Ludovici, Donald W., Kavash, Robert W., Kukla, Michael J., Ho, Chih Y., Ye, Hong, De Corte, Bart L., Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, Moereels, Henry E.L., Heeres, Jan, Koymans, Lucien M.H., de Jonge, Marc R., Van Aken, Koen J.A., Daeyaert, Frederik F.D., J. Lewi, Paul, Das, Kalyan, Arnold, Edward, Janssen, Paul A.J.

“…A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the…”
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