Search Results - "Daehn, Ilse S"

The glomerular filtration barrier: a structural target for novel kidney therapies by Daehn, Ilse S., Duffield, Jeremy S.

“…Loss of normal kidney function affects more than 10% of the population and contributes to morbidity and mortality. Kidney diseases are currently treated with…”
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Molecular Mechanisms in Early Diabetic Kidney Disease: Glomerular Endothelial Cell Dysfunction by Lassén, Emelie, Daehn, Ilse S

“…Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD), with prevalence increasing at an alarming rate worldwide and today, there…”
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The diabetic microenvironment causes mitochondrial oxidative stress in glomerular endothelial cells and pathological crosstalk with podocytes by Casalena, Gabriella A, Yu, Liping, Gil, Roberto, Rodriguez, Samuel, Sosa, Shantel, Janssen, William, Azeloglu, Evren U, Leventhal, Jeremy S, Daehn, Ilse S

“…In the setting of diabetes mellitus, mitochondrial dysfunction and oxidative stress are important pathogenic mechanisms causing end organ damage, including…”
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Modeling the Glomerular Filtration Barrier and Intercellular Crosstalk by Ebefors, Kerstin, Lassén, Emelie, Anandakrishnan, Nanditha, Azeloglu, Evren U., Daehn, Ilse S.

“…The glomerulus is a compact cluster of capillaries responsible for blood filtration and initiating urine production in the renal nephrons. A trilaminar…”
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Editorial: Molecular mechanisms of proteinuria, volume II by Daehn, Ilse S., Merscher, Sandra

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Emerging Roles of Xanthine Oxidoreductase in Chronic Kidney Disease by Korsmo, Hunter W, Ekperikpe, Ubong S, Daehn, Ilse S

“…Xanthine Oxidoreductase (XOR) is a ubiquitous, essential enzyme responsible for the terminal steps of purine catabolism, ultimately producing uric acid that is…”
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Mitochondria Matter: A Critical Role of ADCK4 in Stabilizing the CoQ Complex in Podocytes in Steroid-Resistant Nephrotic Syndrome by Daehn, Ilse S

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Tackling chronic kidney disease in diabetic patients with finerenone by Das, Bhaskar, Daehn, Ilse S.

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Hypertrophy and glomerular cell adaptation through crosstalk leads to glomerular injury after kidney transplantation by Lassen, Emelie, Daehn, Ilse S

“…Menon et al. report cell-specific transcriptional changes in podocytes and glomerular endothelial cells that indicate cell stress and increased bidirectional…”
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Integrity of the Glomerular Filtration Barrier: The Impact of Adhesion G-Protein-Coupled Receptor F5 on Glomerular Endothelial Cells by Ekperikpe, Ubong S, Daehn, Ilse S

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Aging kidneys reveal underlying mechanisms of endothelial dysfunction by Ekperikpe, Ubong S, Daehn, Ilse S

“…Jiang et al. show that zinc finger FYVE-type containing 21, a Rab5 effector in glomerular endothelial cells is involved in the maintenance of glomerular…”
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Insights into glomerular function and disease pathogenesis by Lassén, Emelie, Daehn, Ilse S.

“…More than three-quarters of cases of chronic kidney disease are caused by glomerular diseases with glomerulosclerosis, including diabetic kidney disease,…”
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Disability innovation strengthens STEM by Daehn, Ilse S, Croxson, Paula L

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Podocyte as the link between sterile inflammation and diabetic kidney disease by Lassén, Emelie, Bouchareb, Rihab, Daehn, Ilse S

“…Shahzad et al. examined the underlying mechanisms of sterile inflammation in diabetic kidney disease, specifically the role of NLRP3 inflammasome activation in…”
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Redox regulation in diabetic kidney disease by Daehn, Ilse S, Ekperikpe, Ubong S, Stadler, Krisztian

“…Diabetic kidney disease (DKD) is one of the most devastating complications of diabetes mellitus, where currently there is no cure available. Several important…”
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Effect of Aging and a Dual Orexin Receptor Antagonist on Sleep Architecture and Non-REM Oscillations Including an REM Behavior Disorder Phenotype in the PS19 Mouse Model of Tauopathy by Kam, Korey, Vetter, Kenny, Tejiram, Rachel A, Pettibone, Ward D, Shim, Kaitlyn, Audrain, Mickael, Yu, Liping, Daehn, Ilse S, Ehrlich, Michelle E, Varga, Andrew W

“…The impact of tau pathology on sleep microarchitecture features, including slow oscillations, spindles, and their coupling, has been understudied, despite the…”
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Open-Source System for Real-Time Functional Assessment of In Vitro Filtration Barriers by Fallon, Tess K., Zuvin, Merve, Stern, Alan D., Anandakrishnan, Nanditha, Daehn, Ilse S., Azeloglu, Evren U.

“…The integrity of the barrier between blood and the selective filtrate of solutes is important for homeostasis and its disruption contributes to many diseases…”
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Isolation of Conditionally Immortalized Mouse Glomerular Endothelial Cells with Fluorescent Mitochondria by Bouchareb, Rihab, Yu, Liping, Lassen, Emelie, Daehn, Ilse S

“…Glomerular endothelial cell (GEC) dysfunction can initiate and contribute to glomerular filtration barrier breakdown. Increased mitochondrial oxidative stress…”
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182-OR: Genetic Susceptibility to Diabetic Kidney Disease Is Linked to C/EBP-XOR Axis by WANG, QIN, QI, HAIYING, LI, SHUYU, CASALENA, GABRIELLA, YU, LIPING, DAEHN, ILSE S.

“…Diabetic kidney disease (DKD) is the leading single cause of end-stage renal disease in the United States. Approximately 30% of diabetics develop DKD with…”
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Loss of Functional SCO2 Attenuates Oxidative Stress in Diabetic Kidney Disease by Gujarati, Nehaben A, Leonardo, Alexandra R, Vasquez, Jessica M, Guo, Yiqing, Frimpong, Bismark O, Fozilov, Elbek, Revelo, Monica P, Daehn, Ilse S, He, John C, Bogenhagen, Daniel, Mallipattu, Sandeep K

“…Increased oxidative stress in glomerular endothelial cells (GEnCs) contributes to early diabetic kidney disease (DKD). While mitochondrial respiratory complex…”
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