Search Results - "Dadey, Rebekah"

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction by Scharping, Nicole E., Menk, Ashley V., Moreci, Rebecca S., Whetstone, Ryan D., Dadey, Rebekah E., Watkins, Simon C., Ferris, Robert L., Delgoffe, Greg M.

“…Although tumor-specific T cells recognize cancer cells, they are often rendered dysfunctional due to an immunosuppressive microenvironment. Here we showed that…”
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Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity by Overacre-Delgoffe, Abigail E., Chikina, Maria, Dadey, Rebekah E., Yano, Hiroshi, Brunazzi, Erin A., Shayan, Gulidanna, Horne, William, Moskovitz, Jessica M., Kolls, Jay K., Sander, Cindy, Shuai, Yongli, Normolle, Daniel P., Kirkwood, John M., Ferris, Robert L., Delgoffe, Greg M., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A.A.

“…Regulatory T cells (Tregs) are a barrier to anti-tumor immunity. Neuropilin-1 (Nrp1) is required to maintain intratumoral Treg stability and function but is…”
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Interferon-γ Drives T reg Fragility to Promote Anti-tumor Immunity by Overacre-Delgoffe, Abigail E, Chikina, Maria, Dadey, Rebekah E, Yano, Hiroshi, Brunazzi, Erin A, Shayan, Gulidanna, Horne, William, Moskovitz, Jessica M, Kolls, Jay K, Sander, Cindy, Shuai, Yongli, Normolle, Daniel P, Kirkwood, John M, Ferris, Robert L, Delgoffe, Greg M, Bruno, Tullia C, Workman, Creg J, Vignali, Dario A A

“…Regulatory T cells (T ) are a barrier to anti-tumor immunity. Neuropilin-1 (Nrp1) is required to maintain intratumoral T stability and function but is…”
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The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction by Scharping, Nicole E., Menk, Ashley V., Moreci, Rebecca S., Whetstone, Ryan D., Dadey, Rebekah E., Watkins, Simon C., Ferris, Robert L., Delgoffe, Greg M.

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Partial tumor irradiation plus pembrolizumab in treating large advanced solid tumor metastases by Korpics, Mark C, Onderdonk, Benjamin E, Dadey, Rebekah E, Hara, Jared H, Karapetyan, Lilit, Zha, Yuanyuan, Karrison, Theodore G, Olson, Adam C, Fleming, Gini F, Weichselbaum, Ralph R, Bao, Riyue, Chmura, Steven J, Luke, Jason J

“…BACKGROUNDWe previously demonstrated the safety of stereotactic body radiotherapy followed by pembrolizumab (SBRT+P) in patients with advanced solid tumors…”
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Regulatory T Cells in the Tumor Microenvironment by Dadey, Rebekah E, Workman, Creg J, Vignali, Dario A A

“…Regulatory T cells (T ) are an immunosuppressive subpopulation of CD4 T cells that are endowed with potent suppressive activity and function to limit immune…”
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Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum are prognostic of melanoma patient outcomes by Karapetyan, Lilit, AbuShukair, Hassan M, Li, Aofei, Knight, Andrew, Al Bzour, Ayah Nedal, MacFawn, Ian P, Thompson, Zachary J, Chen, Ann, Yang, Xi, Dadey, Rebekah, Karunamurthy, Arivarasan, De Stefano, Danielle Vargas, Sander, Cindy, Kunning, Sheryl R, Najjar, Yana G, Davar, Diwakar, Luke, Jason J, Gooding, William, Bruno, Tullia C, Kirkwood, John M, Storkus, Walter J

“…Proinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME). In the…”
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Regulatory T Cell-Derived TRAIL Is Not Required for Peripheral Tolerance by Dadey, Rebekah E, Grebinoski, Stephanie, Zhang, Qianxia, Brunazzi, Erin A, Burton, Amanda, Workman, Creg J, Vignali, Dario A A

“…TRAIL ( /TRAIL/CD253/Apo2L) is an important immune molecule that mediates apoptosis. TRAIL can play key roles in regulating cell death in the tumor and…”
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Partial tumor irradiation plus pembrolizumab in treating large advanced solid tumor metastases by Korpics, Mark Charles, Onderdonk, Benjamin Ernst, Dadey, Rebekah E, Hara, Jared H, Karapetyan, Lilit, Zha, Yuanyuan, Karrison, Theodore, Olson, Adam C., Fleming, Gini F., Weichselbaum, Ralph R., Bao, Riyue, Chmura, Steven J., Luke, Jason J.

“…2593 Background: We previously demonstrated the safety of stereotactic body radiotherapy followed by pembrolizumab (SBRT+P) in patients with advanced solid…”
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Treg-restricted deletion of TRAIL (Tnfsf10) reduces autoimmune diabetes by Dadey, Rebekah, Grebinoski, Stephanie J, Zhang, Qianxia, Gocher, Angela, Brunazzi, Erin, Andrews, Lawrence Peter, Burton, Amanda, Workman, Creg, Vignali, Dario

“…Regulatory T cells (Tregs) are a suppressive cell population that limit the anti-tumor response. One mechanism Tregs utilize is production of suppressive…”
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Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum: Outcomes for patients with melanoma by Karapetyan, Lilit, Abushukair, Hassan Mohammed, Li, Aofei, Knight, Andrew David, Al-Bzour, Ayah N., Macfawn, Ian, Thompson, Zachary, Chen, Ann, Dadey, Rebekah E., Karunamurthy, Arivarasan, Vargas De Stefano, Danielle, Sander, Cindy, Kunning, Sheryl, Najjar, Yana G., Davar, Diwakar, Luke, Jason J., Gooding, William E., Bruno, Tullia C., Kirkwood, John M. M., Storkus, Walter J.

“…9565 Background: Proinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor immune…”
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Checks and Balances of T Cells in Inflammatory Environments by Dadey, Rebekah E

“…The immune system is composed of many checks and balances that are critical to limiting disease and maintaining homeostasis. T cells are critical regulators of…”
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Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8+ T Cells by Somasundaram, Ashwin, Cillo, Anthony R, Lampenfeld, Caleb, Workman, Creg J, Kunning, Sheryl, Oliveri, Lauren, Velez, Maria, Joyce, Sonali, Calderon, Michael, Dadey, Rebekah, Rajasundaram, Dhivyaa, Normolle, Daniel P, Watkins, Simon C, Herman, James G, Kirkwood, John M, Lipson, Evan J, Ferris, Robert L, Bruno, Tullia C, Vignali, Dario A A

“…Many cancer patients do not develop a durable response to the current standard-of-care immunotherapies, despite substantial advances in targeting immune…”
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1280 Radiomic and clinical prediction of overall and organ-specific response to ipilimumab-nivolumab in melanoma by Gray, Zane, Tompkins, Alexandra, Dadey, Rebekah, Zenkin, Serafettin, Amouzegar, Afsaneh, Mamindla, Priyadarshini, Peddagangireddy, Vishal, Ak, Murat, Ryan, Augustin, Colen, Rivka, Bao, Riyue, Luke, Jason

“…BackgroundRadiomics converts medical images into quantitative features and has potential in development of non-invasive biomarkers for cancer treatment…”
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