Search Results - "Dadey, David"
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Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non-Small Cell Lung Cancer Cell Lines and Tumor Models
Published in Clinical cancer research (15-05-2017)“…Non-small cell lung cancer (NSCLC) and glioblastoma multiforme (GBM) have poor median survival. NSCLC and GBM overexpress glucose regulated protein 78 (GRP78),…”
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An NAD⁺-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma
Published in Proceedings of the National Academy of Sciences - PNAS (20-12-2016)“…Accumulating evidence suggests cancer cells exhibit a dependency on metabolic pathways regulated by nicotinamide adenine dinucleotide (NAD⁺). Nevertheless, how…”
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PERK Regulates Glioblastoma Sensitivity to ER Stress Although Promoting Radiation Resistance
Published in Molecular cancer research (01-10-2018)“…The aggressive nature and inherent therapeutic resistance of glioblastoma multiforme (GBM) has rendered the median survival of afflicted patients to 14 months…”
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Socio-economic disparities influence likelihood of post-operative radiation to resection cavities of metastatic brain tumors
Published in Acta neurochirurgica (01-12-2023)“…Purpose Irradiating the surgical bed of resected brain metastases improves local and distant disease control. Over time, stereotactic radiosurgery (SRS) has…”
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Impact of socio-economic factors on radiation treatment after resection of metastatic brain tumors: trends from a private insurance database
Published in Journal of neuro-oncology (01-07-2022)“…Background Stereotactic radiosurgery (SRS) to the surgical bed of resected brain metastases is now considered the standard of care due to its advantages over…”
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Risk of developing glioblastoma following non-CNS primary cancer: a SEER analysis between 2000 and 2018
Published in Journal of neuro-oncology (01-09-2023)“…Background Patients with a prior malignancy are at elevated risk of developing subsequent primary malignancies (SPMs). However, the risk of developing…”
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The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma
Published in Oncotarget (12-01-2016)“…Therapeutic resistance is a major barrier to improvement of outcomes for patients with glioblastoma. The endoplasmic reticulum stress response (ERSR) has been…”
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Tumor-Specific Binding of Radiolabeled PEGylated GIRLRG Peptide: A Novel Agent for Targeting Cancers
Published in Journal of Nuclear Medicine (01-12-2016)“…Cancer-specific targeting sparing normal tissues would significantly enhance cancer therapy outcomes and reduce cancer-related mortality. One approach is to…”
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Nucleophosmin Serves as a Rate-Limiting Nuclear Export Chaperone for the Mammalian Ribosome
Published in Molecular and Cellular Biology (01-12-2008)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Stereotactic radiosurgery for sarcoma metastases to the brain: a single-institution experience
Published in Neurosurgical focus (01-08-2023)“…Brain metastases (BMs) secondary to sarcoma are rare, and their incidence ranges from 1% to 8% of all bone and soft tissue sarcomas. Although stereotactic…”
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Laser interstitial thermal therapy for subependymal giant cell astrocytoma: technical case report
Published in Neurosurgical focus (01-10-2016)“…Subependymal giant cell astrocytoma (SEGA) is a rare tumor occurring almost exclusively in patients with tuberous sclerosis complex. Although open resection…”
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Electrophysiology and Structural Connectivity of the Posterior Hypothalamic Region: Much to Learn From a Rare Indication of Deep Brain Stimulation
Published in Frontiers in human neuroscience (15-05-2020)“…Cluster headache (CH) is among the most common and debilitating autonomic cephalalgias. We characterize clinical outcomes of deep brain stimulation (DBS) to…”
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Blocking the functional domain of TIP1 by antibodies sensitizes cancer to radiation therapy
Published in Biomedicine & pharmacotherapy (01-10-2023)“…Non-small-cell lung cancer (NSCLC) and glioblastoma (GB) have poor prognoses. Discovery of new molecular targets is needed to improve therapy. Tax interacting…”
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Utilizing personalized stereotactic frames for laser interstitial thermal ablation of posterior fossa and mesiotemporal brain lesions: a single-institution series
Published in Neurosurgical focus (01-10-2016)“…OBJECTIVE The precision of laser probe insertion for interstitial thermal therapy of deep-seated lesions is limited by the method of stereotactic guidance. The…”
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Deep Brain Stimulation for Chronic Cluster Headache: A Review
Published in Neuromodulation (Malden, Mass.) (01-06-2019)“…Cluster headaches are a set of episodic and chronic pain syndromes that are sources of significant morbidity for patients. The standard of care for cluster…”
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Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines
Published in Frontiers in oncology (01-01-2013)“…Glioblastoma multiforme (GBM) is an aggressive primary brain tumor that is radio-resistant and recurs despite aggressive surgery, chemo, and radiotherapy…”
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High-throughput identification of putative receptors for cancer-binding peptides using biopanning and microarray analysis
Published in Integrative biology (Cambridge) (01-02-2013)“…Phage-display peptide biopanning has been successfully used to identify cancer-targeting peptides in multiple models. For cancer-binding peptides,…”
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Targeting Tax Interacting Protein 1 Results in Cytotoxic and Radiosensitizing Effects in Cancer
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626 From the Stroke Belt to San Francisco: Racial Disparities in Stroke Persist
Published in Neurosurgery (01-04-2023)“…INTRODUCTION: Racial disparities in stroke are classically observed in geographical areas carrying the greatest stroke burden and mortality, namely the Stroke…”
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869 Loss to Follow-Up for Radiation Treatment After Resection of Metastatic Brain Tumors: Analysis of a Non-Irradiated Cohort from a Private Insurance Database
Published in Neurosurgery (01-04-2023)“…INTRODUCTION: Radiation treatment to the surgical bed of resected brain metastases is considered the standard of care due to its advantages in improving local…”
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