Oxidative stress markers in adults 2 years after Roux-en-Y gastric bypass

INTRODUCTIONObesity is a chronic disease associated with oxidative stress. Bariatric surgery for the treatment of obesity may affect biomarkers of oxidative stress. OBJECTIVESThe aim of the present study was to evaluate the effect of Roux-en-Y gastric bypass (RYGB) on blood markers of oxidative stre...

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Published in:	European journal of gastroenterology & hepatology Vol. 25; no. 5; pp. 580 - 586
Main Authors:	Dadalt, Carla, Fagundes, Regina L M, Moreira, Emilia. A M, Wilhelm-Filho, Danilo, de Freitas, Maiara B, Jordão Júnior, Alceu A, Biscaro, Fernanda, Pedrosa, Rozangela C, Vannucchi, Hélio
Format:	Journal Article
Language:	English
Published:	England Lippincott Williams & Wilkins, Inc 01-05-2013
Subjects:	Adult Anthropometry - methods Ascorbic Acid - administration & dosage Ascorbic Acid - blood beta Carotene - administration & dosage beta Carotene - blood Biomarkers - blood Body Mass Index Body Weight - physiology Catalase - blood Energy Intake - physiology Female Gastric Bypass Glutathione - blood Humans Male Obesity - blood Obesity - physiopathology Obesity - surgery Oxidative Stress - physiology Postoperative Period Prospective Studies Thiobarbituric Acid Reactive Substances - metabolism Vitamin E - administration & dosage Vitamin E - blood
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Summary:	INTRODUCTIONObesity is a chronic disease associated with oxidative stress. Bariatric surgery for the treatment of obesity may affect biomarkers of oxidative stress. OBJECTIVESThe aim of the present study was to evaluate the effect of Roux-en-Y gastric bypass (RYGB) on blood markers of oxidative stress, such as vitamins C and E, β-carotene, reduced glutathione (GSH), catalase (CAT), ferric reducing antioxidant potential (FRAP), and thiobarbituric acid-reactive substances (TBARS). METHODSA prospective controlled clinical trial was carried out. The participants were distributed into two groupsa control group (n=35), which was evaluated once, and a bariatric group (n=35), which was evaluated at baseline as well as 6, 12, and 24 months after surgery. RESULTSAfter surgery, the BMI decreased from 47.05±1.46 to 30.53±1.14 kg/m (P<0.001), but 25.7% of the participants regained weight after 24 months. In relation to the baseline, postsurgery reductions were found in vitamin C (31.9±4.6%, P<0.001), β-carotene (360.7±368.3%, P<0.001), vitamin E (22.8±4.1%, P<0.001), GSH (6.6±5.2%, P=0.090), CAT (12.7±5.6%, P=0.029), and FRAP (1.2±3.8%, P=0.085) 2 years after RYGB. TBARS levels decreased after 12 months (71.6±2.9%, P<0.001) in relation to the baseline but increased by 195.0±28.2% between the 12th and the 24th month (P<0.001). CONCLUSIONThe present findings show that oxidative stress returned 2 years after RYGB. Concentrations of vitamin C, β-carotene, GSH, CAT, and FRAP were decreased, whereas the concentration of TBARS decreased in the first year but increased in the following year, which may be partly explained by the imbalance between antioxidants and pro-oxidants.
ISSN:	0954-691X 1473-5687
DOI:	10.1097/MEG.0b013e32835d0ae0