Search Results - "Dacosta, Ralph"

Multifunctional Albumin–MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and Enhance Radiation Response by Prasad, Preethy, Gordijo, Claudia R, Abbasi, Azhar Z, Maeda, Azusa, Ip, Angela, Rauth, Andrew Michael, DaCosta, Ralph S, Wu, Xiao Yu

“…Insufficient oxygenation (hypoxia), acidic pH (acidosis), and elevated levels of reactive oxygen species (ROS), such as H2O2, are characteristic abnormalities…”
Get full text

Customizable optical tissue phantom platform for characterization of fluorescence imaging device sensitivity by Gibson, Christopher, Phoon, Arcturus, DaCosta, Ralph S.

“…SignificanceOptical tissue phantoms serve as inanimate and stable reference materials used to calibrate, characterize, standardize, and test biomedical imaging…”
Get full text

New insights into spatio-temporal dynamics of mesenchymal progenitor cell ingress during peri-implant wound healing: Provided by intravital imaging by Khosravi, Niloufar, DaCosta, Ralph S., Davies, John E.

“…Surface topography drives the success of orthopedic and dental implants placed in bone, by directing the biology occurring at the tissue-implant interface…”
Get full text

DORA-compliant measures of research quality and impact to assess the performance of researchers in biomedical institutions: Review of published research, international best practice and Delphi survey by Gagliardi, Anna R, Chen, Rob H C, Boury, Himani, Albert, Mathieu, Chow, James, DaCosta, Ralph S, Hoffman, Michael, Keshavarz, Behrang, Kontos, Pia, Liu, Jenny, McAndrews, Mary Pat, Protze, Stephanie

“…The San Francisco Declaration on Research Assessment (DORA) advocates for assessing biomedical research quality and impact, yet academic organizations continue…”
Get full text

Point-of-care autofluorescence imaging for real-time sampling and treatment guidance of bioburden in chronic wounds: first-in-human results by DaCosta, Ralph S, Kulbatski, Iris, Lindvere-Teene, Liis, Starr, Danielle, Blackmore, Kristina, Silver, Jason I, Opoku, Julie, Wu, Yichao Charlie, Medeiros, Philip J, Xu, Wei, Xu, Lizhen, Wilson, Brian C, Rosen, Cheryl, Linden, Ron

“…Traditionally, chronic wound infection is diagnosed by visual inspection under white light and microbiological sampling, which are subjective and suboptimal,…”
Get full text

Hybrid Manganese Dioxide Nanoparticles Potentiate Radiation Therapy by Modulating Tumor Hypoxia by Abbasi, Azhar Z, Gordijo, Claudia R, Amini, Mohammad Ali, Maeda, Azusa, Rauth, Andrew M, DaCosta, Ralph S, Wu, Xiao Yu

“…Hypoxia in the tumor microenvironment (TME) mediates resistance to radiotherapy and contributes to poor prognosis in patients receiving radiotherapy. Here we…”
Get full text

A Multifunctional Polymeric Nanotheranostic System Delivers Doxorubicin and Imaging Agents across the Blood–Brain Barrier Targeting Brain Metastases of Breast Cancer by Li, Jason, Cai, Ping, Shalviri, Alireza, Henderson, Jeffrey T, He, Chunsheng, Foltz, Warren D, Prasad, Preethy, Brodersen, Peter M, Chen, Yonghong, DaCosta, Ralph, Rauth, Andrew Michael, Wu, Xiao Yu

“…Metastatic brain cancers, in particular cancers with multiple lesions, are one of the most difficult malignancies to treat owing to their location and…”
Get full text

Assessing the Accuracy of Bioluminescence Image-Guided Stereotactic Body Radiation Therapy of Orthotopic Pancreatic Tumors Using a Small Animal Irradiator by Rapic, Sara, Samuel, Timothy, Lindsay, Patricia E., Ansell, Steve, Weersink, Robert A., DaCosta, Ralph S.

“…Stereotactic body radiation therapy (SBRT) has shown promising results in the treatment of pancreatic cancer and other solid tumors. However, wide adoption of…”
Get full text

In vitro detection of porphyrin-producing wound bacteria with real-time fluorescence imaging by Jones, Laura M, Dunham, Danielle, Rennie, Monique Y, Kirman, Jeffrey, Lopez, Andrea J, Keim, Klara C, Little, William, Gomez, Andre, Bourke, Jessica, Ng, Herman, DaCosta, Ralph S, Smith, Allie Clinton

“…Fluorescence imaging can visualize polymicrobial populations in chronic and acute wounds based on porphyrin fluorescence. We investigated the fluorescent…”
Get full text

In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model by Maeda, Azusa, PhD, Chen, Yonghong, MSc, MD, Bu, Jiachuan, MSc, Mujcic, Hilda, PhD, Wouters, Bradly G., PhD, DaCosta, Ralph S., PhD

“…Purpose To investigate the effect of high-dose irradiation on pancreatic tumor vasculature and microenvironment using in vivo imaging techniques. Methods and…”
Get full text

Texture analysis of optical coherence tomography speckle for characterizing biological tissues in vivo by Lindenmaier, Andras A, Conroy, Leigh, Farhat, Golnaz, DaCosta, Ralph S, Flueraru, Costel, Vitkin, I Alex

“…We demonstrate a method for differentiating tissue disease states using the intrinsic texture properties of speckle in optical coherence tomography (OCT)…”
Get more information

Intraoperative fluorescence imaging with aminolevulinic acid detects grossly occult breast cancer: a phase II randomized controlled trial by Ottolino-Perry, Kathryn, Shahid, Anam, DeLuca, Stephanie, Son, Viktor, Sukhram, Mayleen, Meng, Fannong, Liu, Zhihui Amy, Rapic, Sara, Anantha, Nayana Thalanki, Wang, Shirley C, Chamma, Emilie, Gibson, Christopher, Medeiros, Philip J, Majeed, Safa, Chu, Ashley, Wignall, Olivia, Pizzolato, Alessandra, Rosen, Cheryl F, Teene, Liis Lindvere, Starr-Dunham, Danielle, Kulbatski, Iris, Panzarella, Tony, Done, Susan J, Easson, Alexandra M, Leong, Wey L, DaCosta, Ralph S

“…Re-excision due to positive margins following breast-conserving surgery (BCS) negatively affects patient outcomes and healthcare costs. The inability to…”
Get full text

Quantitative intravital imaging for real-time monitoring of pancreatic tumor cell hypoxia and stroma in an orthotopic mouse model by Samuel, Timothy, Rapic, Sara, O'Brien, Cristiana, Edson, Michael, Zhong, Yuan, DaCosta, Ralph S

“…Pancreatic cancer is a lethal disease with few successful treatment options. Recent evidence demonstrates that tumor hypoxia promotes pancreatic tumor…”
Get full text

Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis by Khosravi, Niloufar, Maeda, Azusa, DaCosta, Ralph S., Davies, John E.

“…Nanosurfaces have improved clinical osseointegration by increasing bone/implant contact. Neovascularization is considered an essential prerequisite to…”
Get full text

Quantifying tissue microvasculature with speckle variance optical coherence tomography by Conroy, Leigh, DaCosta, Ralph S, Vitkin, I Alex

“…In this Letter, we demonstrate high resolution, three-dimensional optical imaging of in vivo blood vessel networks using speckle variance optical coherence…”
Get more information

Improved detection of clinically relevant wound bacteria using autofluorescence image‐guided sampling in diabetic foot ulcers by Ottolino‐Perry, Kathryn, Chamma, Emilie, Blackmore, Kristina M, Lindvere‐Teene, Liis, Starr, Danielle, Tapang, Kim, Rosen, Cheryl F, Pitcher, Bethany, Panzarella, Tony, Linden, Ron, DaCosta, Ralph S

“…Clinical wound assessment involves microbiological swabbing of wounds to identify and quantify bacterial species, and to determine microbial susceptibility to…”
Get full text

Engineering functional microvessels in synthetic polyurethane random-pore scaffolds by harnessing perfusion flow by Wright, Meghan EE, Yu, Jonathan K., Jain, Devika, Maeda, Azusa, Yeh, Shu-Chi A., DaCosta, Ralph S., Lin, Charles P., Santerre, J. Paul

“…Recently reported biomaterial-based approaches toward prevascularizing tissue constructs rely on biologically or structurally complex scaffolds that are…”
Get full text

Dual in vivo Photoacoustic and Fluorescence Imaging of HER2 Expression in Breast Tumors for Diagnosis, Margin Assessment, and Surgical Guidance by Maeda, Azusa, Bu, Jiachuan, Chen, Juan, Zheng, Gang, DaCosta, Ralph S.

“…Biomarker-specific imaging probes offer ways to improve molecular diagnosis, intraoperative margin assessment, and tumor resection. Fluorescence and…”
Get full text

A spinal cord window chamber model for in vivo longitudinal multimodal optical and acoustic imaging in a murine model by Figley, Sarah A, Chen, Yonghong, Maeda, Azusa, Conroy, Leigh, McMullen, Jesse D, Silver, Jason I, Stapleton, Shawn, Vitkin, Alex, Lindsay, Patricia, Burrell, Kelly, Zadeh, Gelareh, Fehlings, Michael G, DaCosta, Ralph S

“…In vivo and direct imaging of the murine spinal cord and its vasculature using multimodal (optical and acoustic) imaging techniques could significantly advance…”
Get full text

In vivo optical imaging of tumor and microvascular response to ionizing radiation by Maeda, Azusa, Leung, Michael K K, Conroy, Leigh, Chen, Yonghong, Bu, Jiachuan, Lindsay, Patricia E, Mintzberg, Shani, Virtanen, Carl, Tsao, Julissa, Winegarden, Neil A, Wang, Yanchun, Morikawa, Lily, Vitkin, I Alex, Jaffray, David A, Hill, Richard P, DaCosta, Ralph S

“…Radiotherapy is a widely used cancer treatment. However, understanding how ionizing radiation affects tumor cells and their vasculature, particularly at…”
Get full text