Search Results - "Dack, K."

COVID-19 associated with universities in England, October 2020–February 2022 by Dack, K., Wilson, A., Turner, C., Anderson, C., Hughes, G.J.

“…The aim of this study was to describe the epidemiology of COVID-19 cases at universities in England (October 2020–February 2022) and investigate factors…”
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In vitro and in vivo characterization of PF‐04418948, a novel, potent and selective prostaglandin EP 2 receptor antagonist by af Forselles, KJ, Root, J, Clarke, T, Davey, D, Aughton, K, Dack, K, Pullen, N

“…BACKGROUND AND PURPOSE Studies of the role of the prostaglandin EP 2 receptor) have been limited by the availability of potent and selective antagonist tools…”
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Self-management intervention to reduce pulmonary exacerbations by supporting treatment adherence in adults with cystic fibrosis: a randomised controlled trial by Wildman, Martin J, O'Cathain, Alicia, Maguire, Chin, Arden, Madelynne A, Hutchings, Marlene, Bradley, Judy, Walters, Stephen J, Whelan, Pauline, Ainsworth, John, Buchan, Iain, Mandefield, Laura, Sutton, Laura, Tappenden, Paul, Elliott, Rachel A, Hoo, Zhe Hui, Drabble, Sarah J, Beever, Daniel

“…Recurrent pulmonary exacerbations lead to progressive lung damage in cystic fibrosis (CF). Inhaled medications (mucoactive agents and antibiotics) help prevent…”
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28 Developing a specialist nurse run adult sweat test clinic by Peres, A, Madge, S, Talbot, S, Dack, K, Holder, E, Bilton, D, Simmonds, N.J

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In vitro and in vivo characterization of PF‐04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist by af Forselles, KJ, Root, J, Clarke, T, Davey, D, Aughton, K, Dack, K, Pullen, N

“…BACKGROUND AND PURPOSE Studies of the role of the prostaglandin EP2 receptor) have been limited by the availability of potent and selective antagonist tools…”
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Clinical features of Swine Flu in a major adult CF unit in London by Dhasmana, D.J, Dack, K, Gyi, K, Hodson, M, Bilton, D

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Thromboxane Modulating Agents. 3. 1H-Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists by Dickinson, Roger P, Dack, Kevin N, Long, Clive J, Steele, John

“…The design of a series of dual thromboxane synthase inhibitor/thromboxane receptor antagonists based on a 3-[2-[(arylsulfonyl)amino]ethyl]benzenepropanoic acid…”
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Thromboxane modulating agents. 4. Design and synthesis of 3-(2-[{(4-chlorophenyl)sulfonyl}amino]ethyl)benzenepropanoic acid derivatives as potent thromboxane receptor antagonists by Dack, Kevin N., Dickinson, Roger P., Long, Clive J., Steele, John

“…The design of a series of thromboxane receptor antagonists based on 3-(2-[{(4-chlorophenyl)sulfonyl}amino]ethyl)benzenepropanoic acid ( 1) is described…”
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Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist by Beaumont, Kevin, Webster, Robert, Gardner, Iain, Dack, Kevin

“…Many drugs are administered at sites that are remote from their site of action. The most common route of drug delivery is the oral route. The optimal…”
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Absorption, Distribution, Metabolism, and Excretion Considerations in Selection of Orally Active Indole-Containing Endothelin Antagonist by WALKER, Donald K, DACK, Kevin N, DICKINSON, Roger P, FENNER, Katherine S, JAMES, Kim, RAWSON, David J, SMITH, Dennis A

“…A series of potent indole-containing endothelin antagonists were evaluated in rat pharmacokinetic studies as part of a rational drug design program. Early…”
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Thromboxane-modulating agents by Dickenson, R.P., Dack, K.N., Steele, J.

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The design and synthesis of a novel series of indole derived selective ETA antagonists by RAWSON, David J, DACK, Kevin N, DICKINSON, Roger P, JAMES, Kim

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The Design and Synthesis of a Novel, Orally Active, Selective ETA Antagonist by Rawson, David J., Dack, Kevin N., Dickinson, Roger P., James, Kim, Long, Clive, Walker, Don

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Thromboxane modulating agents. 1. Design of 1-[(arylsulfonyl)amino] alkylindole derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists by Dickinson, Roger P., Dack, Kevin N., Steele, John

“…The design of a series of dual thromboxane synthase inhibitor/thromboxane receptor antagonists based on an indole thromboxane synthase inhibitor template is…”
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Thromboxane modulating agents. 2. Thromboxane receptor antagonists derived from the thromboxane synthase inhibitor dazmegrel by Dickinson, Roger P., Dack, Kevin N., Steele, John, Tute, Michael S.

“…The design of dual thromboxane synthase inhibitor/thromboxane receptor antagonists (e.g. 15) based on the structure of the thromboxane synthase inhibitor…”
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