Search Results - "Dabdoub, Alain"

Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier by Nyberg, Sophie, Abbott, N Joan, Shi, Xiaorui, Steyger, Peter S, Dabdoub, Alain

“…Permanent hearing loss affects more than 5% of the world's population, yet there are no nondevice therapies that can protect or restore hearing. Delivery of…”
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Therapeutic Potential of Wnt and Notch Signaling and Epigenetic Regulation in Mammalian Sensory Hair Cell Regeneration by Samarajeewa, Anshula, Jacques, Bonnie E., Dabdoub, Alain

“…Hearing loss is one of the most prevalent sensory deficits worldwide and can result from the death of mechanosensory hair cells that transduce auditory signals…”
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Dynamic Expression of Sox2, Gata3, and Prox1 during Primary Auditory Neuron Development in the Mammalian Cochlea by Nishimura, Koji, Noda, Teppei, Dabdoub, Alain

“…Primary auditory neurons (PANs) connect cochlear sensory hair cells in the mammalian inner ear to cochlear nucleus neurons in the brainstem. PANs develop from…”
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Atoh1, an Essential Transcription Factor in Neurogenesis and Intestinal and Inner Ear Development: Function, Regulation, and Context Dependency by Mulvaney, Joanna, Dabdoub, Alain

“…Atoh1 (also known as Math1, Hath1, and Cath1 in mouse, human, and chicken, respectively) is a proneural basic helix–loop–helix (bHLH) transcription factor that…”
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Cochlear Implants Meet Regenerative Biology: State of the Science and Future Research Directions by Dabdoub, Alain, Nishimura, Koji

“…The cochlear implant, the first device to restore a human sense, is an electronic substitute for lost mechanosensory hair cells. It has been successful at…”
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Modifier variant of METTL13 suppresses human GAB1-associated profound deafness by Yousaf, Rizwan, Ahmed, Zubair M, Giese, Arnaud Pj, Morell, Robert J, Lagziel, Ayala, Dabdoub, Alain, Wilcox, Edward R, Riazuddin, Sheikh, Friedman, Thomas B, Riazuddin, Saima

“…A modifier variant can abrogate the risk of a monogenic disorder. DFNM1 is a locus on chromosome 1 encoding a dominant suppressor of human DFNB26 recessive,…”
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Pericytes control vascular stability and auditory spiral ganglion neuron survival by Zhang, Yunpei, Neng, Lingling, Sharma, Kushal, Hou, Zhiqiang, Johnson, Anatasiya, Song, Junha, Dabdoub, Alain, Shi, Xiaorui

“…The inner ear has a rich population of pericytes, a multi-functional mural cell essential for sensory hair cell heath and normal hearing. However, the…”
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Transcriptional response to Wnt activation regulates the regenerative capacity of the mammalian cochlea by Samarajeewa, Anshula, Lenz, Danielle R, Xie, Lihong, Chiang, Hao, Kirchner, Rory, Mulvaney, Joanna F, Edge, Albert S B, Dabdoub, Alain

“…Lack of sensory hair cell (HC) regeneration in mammalian adults is a major contributor to hearing loss. In contrast, the neonatal mouse cochlea retains a…”
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Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea by Dabdoub, Alain, Puligilla, Chandrakala, Jones, Jennifer M, Fritzsch, Bernd, Cheah, Kathryn S.E, Pevny, Larysa H, Kelley, Matthew W

“…Sox2 is a high-mobility transcription factor that is one of the earliest markers of developing inner ear prosensory domains. In humans, mutations in SOX2 cause…”
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Sox2 Induces Neuronal Formation in the Developing Mammalian Cochlea by Puligilla, Chandrakala, Dabdoub, Alain, Brenowitz, Stephan D, Kelley, Matthew W

“…In the cochlea, spiral ganglion neurons play a critical role in hearing as they form the relay between mechanosensory hair cells in the inner ear and cochlear…”
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Hearing Function, Degeneration, and Disease: Spotlight on the Stria Vascularis by Thulasiram, Matsya R, Ogier, Jacqueline M, Dabdoub, Alain

“…The stria vascularis (SV) is a highly vascularized tissue lining the lateral wall of the cochlea. The SV maintains cochlear fluid homeostasis, generating the…”
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ASK1 is a novel molecular target for preventing aminoglycoside-induced hair cell death by Ogier, Jacqueline M., Gao, Yujing, Dunne, Eileen M., Wilson, Michael A., Ranganathan, Sarath C., Tesch, Gregory H., Nikolic Paterson, David J., Dabdoub, Alain, Burt, Rachel A., Nayagam, Bryony A., Lockhart, Paul J.

“…Aminoglycoside antibiotics are lifesaving medicines, crucial for the treatment of chronic or drug resistant infections. However, aminoglycosides are toxic to…”
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Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea by Geng, Ruishuang, Noda, Teppei, Mulvaney, Joanna F, Lin, Vincent Y W, Edge, Albert S B, Dabdoub, Alain

“…In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary…”
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Correction to: ASK1 is a novel molecular target for preventing aminoglycoside‑induced hair cell death by Ogier, Jacqueline M., Gao, Yujing, Dunne, Eileen M., Wilson, Michael A., Ranganathan, Sarath C., Tesch, Gregory H., Nikolic Paterson, David J., Dabdoub, Alain, Burt, Rachel A., Nayagam, Bryony A., Lockhart, Paul J.

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In vitro Methods to Cultivate Spiral Ganglion Cells, and Purification of Cellular Subtypes for Induced Neuronal Reprogramming by Meas, Steven J, Nishimura, Koji, Scheibinger, Mirko, Dabdoub, Alain

“…Hearing loss can develop as a consequence of primary auditory neuron degeneration. These neurons are present within the spiral ganglion of the inner ear and…”
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Leveraging large-scale datasets and single cell omics data to develop a polygenic score for cisplatin-induced ototoxicity by Miao, Deanne Nixie R, Wilke, MacKenzie A P, Pham, John, Ladha, Feryal, Singh, Mansumeet, Arsenio, Janilyn, Luca, Emilia, Dabdoub, Alain, Yang, Wejian, Yang, Jun J, Drögemöller, Britt I

“…Cisplatin-induced ototoxicity (CIO), characterized by irreversible and progressive bilateral hearing loss, is a prevalent adverse effect of cisplatin…”
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Extracellular Biomarkers of Inner Ear Disease and Their Potential for Point‐of‐Care Diagnostics by Mahshid, Sahar Sadat, Higazi, Aliaa Monir, Ogier, Jacqueline Michelle, Dabdoub, Alain

“…Rapid diagnostic testing has become a mainstay of patient care, using easily obtained samples such as blood or urine to facilitate sample analysis at the…”
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The Wnt Receptor Ryk Plays a Role in Mammalian Planar Cell Polarity Signaling by Macheda, Maria L., Sun, Willy W., Kugathasan, Kumudhini, Hogan, Benjamin M., Bower, Neil I., Halford, Michael M., Zhang, You Fang, Jacques, Bonnie E., Lieschke, Graham J., Dabdoub, Alain, Stacker, Steven A.

“…Wnts are essential for a wide range of developmental processes, including cell growth, division, and differentiation. Some of these processes signal via the…”
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Reprogramming Glia Into Neurons in the Peripheral Auditory System as a Solution for Sensorineural Hearing Loss: Lessons From the Central Nervous System by Meas, Steven J, Zhang, Chun-Li, Dabdoub, Alain

“…Disabling hearing loss affects over 5% of the world's population and impacts the lives of individuals from all age groups. Within the next three decades, the…”
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Direct Reprogramming of Spiral Ganglion Non-neuronal Cells into Neurons: Toward Ameliorating Sensorineural Hearing Loss by Gene Therapy by Noda, Teppei, Meas, Steven J, Nogami, Jumpei, Amemiya, Yutaka, Uchi, Ryutaro, Ohkawa, Yasuyuki, Nishimura, Koji, Dabdoub, Alain

“…Primary auditory neurons (PANs) play a critical role in hearing by transmitting sound information from the inner ear to the brain. Their progressive…”
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