Comparative Evaluation of Serum Urea, Uric Acid, and Creatine Kinase Levels in Oral Cancer and Potentially Malignant Disorders of the Oral Cavity: A Clinico-Biochemical Study

Comparative Evaluation of Serum Urea, Uric Acid, and Creatine Kinase Levels in Oral Cancer and Potentially Malignant Disorders of the Oral Cavity: A Clinico-Biochemical Study

Introduction Evidence suggests that oral potentially malignant disorders (OPMDs) are linked to increased possibilities of malignant transformation, creating a challenging situation. If oral cancer is detected early, the prognosis is better. The purpose of this study was to compare the serum levels o...

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Published in:Curēus (Palo Alto, CA) Vol. 15; no. 5; p. e39123
Main Authors: Dharmana, Lavanya, Pottam, Anupama, Kollabathula, Sandya Rani, Kumar, P Suresh, Birra, Vinod, Dabbiru, Rupa Chandini
Format: Journal Article
Language:English
Published: United States Cureus Inc 17-05-2023
Cureus
Subjects:
Age
Dentistry
Females
Nonsteroidal anti-inflammatory drugs
Oral cancer
Smoking
Tobacco
Uric acid
Variance analysis
United States > US
Indian subcontinent
India
creatine kinase
opmd
uric acid
oral cancer
urea
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Summary:Introduction Evidence suggests that oral potentially malignant disorders (OPMDs) are linked to increased possibilities of malignant transformation, creating a challenging situation. If oral cancer is detected early, the prognosis is better. The purpose of this study was to compare the serum levels of urea, uric acid (UA), and creatine kinase in patients with provisionally diagnosed and histopathologically confirmed cases of potentially malignant disorders and oral cancer to those of age- and sex-matched healthy controls. Materials and methods Eighty patients over the age of 18 with a clinical diagnosis of oral potentially malignant disorder (OPMD) or oral cancer and verified histopathology were included in the research. Using the kinetic methodology, the enzymatic colorimetric method, and the UV-kinetic approach, respectively, the serum concentrations of urea, uric acid, and creatine kinase were quantified in vitro following the venipuncture of 2 mL of venous blood. The Statistical Package for the Social Sciences (SPSS) version 20 (IBM SPSS Statistics, Armonk, NY, USA) was used for the statistical analysis. Results Comparing OPMD and oral cancer patients to healthy controls, serum urea levels were found to be greater, uric acid levels to be lower, and creatine kinase levels to be higher. Conclusion Prognostic markers for OPMDs and oral cancer may include urea, uric acid, and creatine kinase. However, this may be accomplished by large-scale prospective research.
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.39123