Search Results - "Daadi, Marcel M"

Charting the onset of Parkinson-like motor and non-motor symptoms in nonhuman primate model of Parkinson's disease by Choudhury, Gourav R, Daadi, Marcel M

“…Parkinson's disease is a progressive neurodegenerative disease increasingly affecting our aging population. Remarkable advances have been made in developing…”
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Adherent self-renewable human embryonic stem cell-derived neural stem cell line: functional engraftment in experimental stroke model by Daadi, Marcel M, Maag, Anne-Lise, Steinberg, Gary K

“…Human embryonic stem cells (hESCs) offer a virtually unlimited source of neural cells for structural repair in neurological disorders, such as stroke. Neural…”
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Human Neural Stem Cell Grafts Modify Microglial Response and Enhance Axonal Sprouting in Neonatal Hypoxic―Ischemic Brain Injury by DAADI, Marcel M, DAVIS, Alexis S, ARAC, Ahmet, ZONGJIN LI, MAAG, Anne-Lise, BHATNAGAR, Rishi, JIANG, Kewen, GUOHUA SUN, WU, Joseph C, STEINBERG, Gary K

“…Hypoxic-ischemic (HI) brain injury in newborn infants represents a major cause of cerebral palsy, development delay, and epilepsy. Stem cell-based therapy has…”
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Molecular and Magnetic Resonance Imaging of Human Embryonic Stem Cell–Derived Neural Stem Cell Grafts in Ischemic Rat Brain by Daadi, Marcel M, Li, Zongjin, Arac, Ahmet, Grueter, Brad A, Sofilos, Marc, Malenka, Robert C, Wu, Joseph C, Steinberg, Gary K

“…Real-time imaging of transplanted stem cells is essential for understanding their interactions in vivo with host environments, for tracking cell fate and…”
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Optogenetic Stimulation of Neural Grafts Enhances Neurotransmission and Downregulates the Inflammatory Response in Experimental Stroke Model by Daadi, Marcel M, Klausner, Jill Q, Bajar, Bryce, Goshen, Inbal, Lee-Messer, Christopher, Lee, Soo Yeun, Winge, Mårten C G, Ramakrishnan, Charu, Lo, Maisie, Sun, Guohua, Deisseroth, Karl, Steinberg, Gary K

“…Compelling evidence suggests that transplantation of neural stem cells (NSCs) from multiple sources ameliorates motor deficits after stroke. However, it is…”
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Imaging neural stem cell graft-induced structural repair in stroke by Daadi, Marcel M, Hu, Shijun, Klausner, Jill, Li, Zongjin, Sofilos, Marc, Sun, Guohua, Wu, Joseph C, Steinberg, Gary K

“…Stem cell therapy ameliorates motor deficits in experimental stroke model. Multimodal molecular imaging enables real-time longitudinal monitoring of infarct…”
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Dopaminergic neurons from midbrain-specified human embryonic stem cell-derived neural stem cells engrafted in a monkey model of Parkinson's disease by Daadi, Marcel M, Grueter, Brad A, Malenka, Robert C, Redmond, Jr, D Eugene, Steinberg, Gary K

“…The use of human embryonic stem cells (hESCs) to repair diseased or injured brain is promising technology with significant humanitarian, societal and economic…”
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LRRK2 Attenuates Antioxidant Response in Familial Parkinson's Disease Derived Neural Stem Cells by Kim, Jeffrey, Daadi, Etienne W, Daadi, Elyas Sebastien, Oh, Thomas, Deleidi, Michela, Daadi, Marcel M

“…Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons which leads to…”
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Standards for Deriving Nonhuman Primate-Induced Pluripotent Stem Cells, Neural Stem Cells and Dopaminergic Lineage by Yang, Guang, Hong, Hyenjong, Torres, April, Malloy, Kristen E, Choudhury, Gourav R, Kim, Jeffrey, Daadi, Marcel M

“…Humans and nonhuman primates (NHP) are similar in behavior and in physiology, specifically the structure, function, and complexity of the immune system. Thus,…”
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Isolation and Purification of Self-Renewable Human Neural Stem Cells from iPSCs for Cell Therapy in Experimental Model of Ischemic Stroke by Daadi, Marcel M

“…Neural stem cell therapy has been galvanized by the discovery of pluripotent stem cells. The possibility to generate specialized central nervous…”
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Functional engraftment of the medial ganglionic eminence cells in experimental stroke model by Daadi, Marcel M, Lee, Sang Hyung, Arac, Ahmet, Grueter, Brad A, Bhatnagar, Rishi, Maag, Anne-Lise, Schaar, Bruce, Malenka, Robert C, Palmer, Theo D, Steinberg, Gary K

“…Currently there are no effective treatments targeting residual anatomical and behavioral deficits resulting from stroke. Evidence suggests that cell…”
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Non-cell autonomous mechanism of Parkinson’s disease pathology caused by G2019S LRRK2 mutation in Ashkenazi Jewish patient: Single cell analysis by Kim, Jeffrey, Daadi, Marcel M.

“…[Display omitted] •Single-cell transcriptomic enables unbiased biological discovery.•Differential gene expression revealed dysregulation in genes involved PD…”
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Bioinformatics Analysis of Single-Cell RNA-Seq Raw Data from iPSC-Derived Neural Stem Cells by Kim, Jeffrey, Daadi, Marcel M

“…This chapter describes a pipeline for basic bioinformatics analysis of single-cell sequencing data (see Chap. 10 : Single-Cell Library Preparation). Starting…”
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Generating Neural Stem Cells from iPSCs with Dopaminergic Neurons Reporter Gene by Hong, Hyenjong, Daadi, Marcel M

“…Genetic reporters offer attractive approaches to investigate gene expression, gene function, and spatiotemporal assessment in vitro and in vivo. Tyrosine…”
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Combining physical & cognitive training with iPSC-derived dopaminergic neuron transplantation promotes graft integration & better functional outcome in parkinsonian marmosets by Daadi, Etienne W., Daadi, Elyas S., Oh, Thomas, Li, Mingfeng, Kim, Jeffrey, Daadi, Marcel M.

“…Parkinson's disease (PD) is a relentlessly progressive and currently incurable neurodegenerative disease with significant unmet medical needs. Since PD stems…”
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Single-Cell Library Preparation of iPSC-Derived Neural Stem Cells by Kim, Jeffrey, Daadi, Marcel M

“…Single-cell RNA-seq technology allows for the identification of heterogeneous cell populations, measures stochastic gene expressions, and identifies highly…”
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Generation of Tyrosine Hydroxylase-Producing Neurons from Precursors of the Embryonic and Adult Forebrain by Daadi, Marcel M, Weiss, Samuel

“…We have explored the plastic ability of neuronal precursors to acquire different identities by manipulating their surrounding environment. Specifically, we…”
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Age-related cognitive decline in baboons: modeling the prodromal phase of Alzheimer's disease and related dementias by Lizarraga, Stephanny, Daadi, Etienne W, Roy-Choudhury, Gourav, Daadi, Marcel M

“…The aging of brain cells and synaptic loss are the major underlying pathophysiological processes contributing to the progressive decline in cognitive functions…”
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Distribution of AAV2-hAADC-transduced cells after 3 years in Parkinsonian monkeys by Daadi, Marcel M, Pivirotto, Phillip, Bringas, John, Cunningham, Janet, Forsayeth, John, Eberling, Jamie, Bankiewicz, Krys S

“…The present report describes for the first time, the stability of recombinant adeno-associated virus serotype 2 (AAV2) human aromatic L-amino acid…”
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Dopamine D3 receptor ligand suppresses the expression of levodopa-induced dyskinesia in nonhuman primate model of parkinson's disease by Oh, Thomas, Daadi, Elyas S., Kim, Jeffrey, Daadi, Etienne W., Chen, Peng-Jen, Roy-Choudhury, Gourav, Bohmann, Jonathan, Blass, Benjamin E., Daadi, Marcel M.

“…Parkinson's disease (PD) is a complex multisystem, chronic and so far incurable disease with significant unmet medical needs. The incidence of PD increases…”
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