Search Results - "DaSilva, Jean"

The use of 18F-FDG PET in the diagnosis of cardiac sarcoidosis: a systematic review and metaanalysis including the Ontario experience by Youssef, George, Leung, Eugene, Mylonas, Ilias, Nery, Pablo, Williams, Kathryn, Wisenberg, Gerald, Gulenchyn, Karen Y, Dekemp, Robert A, Dasilva, Jean, Birnie, David, Wells, George A, Beanlands, Rob S B

“…Cardiac sarcoidosis is a potentially fatal complication of sarcoidosis. The 1993 guidelines of the Ministry of Health, Labour, and Welfare (MHLW) of Japan have…”
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Development of a novel [ 18 F]fluorobenzyl derivative of the AT 1 receptor antagonist Candesartan by Alonso Martinez, Luis Michel, DaSilva, Jean N

“…Candesartan is a clinically approved angiotensin II type 1 receptor (AT R)-blocker that selectively binds AT Rs in high affinity. We report here the…”
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Medicinal (Radio) Chemistry: Building Radiopharmaceuticals for the Future by Pijeira, Martha Sahylí Ortega, Nunes, Paulo Sérgio Gonçalves, Chaviano, Samila Leon, Diaz, Aida M Abreu, DaSilva, Jean N, Ricci-Junior, Eduardo, Alencar, Luciana Magalhães Rebelo, Chen, Xiaoyuan, Santos-Oliveira, Ralph

“…Radiopharmaceuticals are increasingly playing a leading role in diagnosing, monitoring, and treating disease. In comparison with conventional pharmaceuticals,…”
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A Reliable Production System of Large Quantities of [ 13 N]Ammonia for Multiple Human Injections by Alonso Martinez, Luis Michel, Naim, Nabil, Saiz, Alejandro Hernandez, Simard, José-Mathieu, Boudjemeline, Mehdi, Juneau, Daniel, DaSilva, Jean N

“…[ N]Ammonia is one of the most commonly used Positron Emission Tomography (PET) radiotracers in humans to assess myocardial perfusion and measure myocardial…”
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Al[18F]F-complexation of DFH17, a NOTA-conjugated adrenomedullin analog, for PET imaging of pulmonary circulation by Alonso Martinez, Luis Michel, Harel, François, Nguyen, Quang T., Létourneau, Myriam, D'Oliviera-Sousa, Caroline, Meloche, Bernard, Finnerty, Vincent, Fournier, Alain, Dupuis, Jocelyn, DaSilva, Jean N.

“…Adrenomedullin receptors are highly expressed in human alveolar capillaries and provide a molecular target for imaging the integrity of pulmonary…”
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Performance of an integrated multimodality image guidance and dose-planning system supporting tumor-targeted HDR brachytherapy for prostate cancer by Grajales, David, Kadoury, Samuel, Shams, Roozbeh, Barkati, Maroie, Delouya, Guila, Béliveau-Nadeau, Dominic, Nicolas, Benedicte, Le, William Trung, Benhacene-Boudam, Mustafa-Karim, Juneau, Daniel, DaSilva, Jean N., Carrier, Jean-Francois, Hautvast, Gilion, Ménard, Cynthia

“…•Image registration and EM tracking were integrated in a system for HDR brachytherapy.•EM enabled use of partially visible catheters within image-validated…”
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[18F]Fluoropyridine‐losartan: A new approach toward human Positron Emission Tomography imaging of Angiotensin II Type 1 receptors by Abreu Diaz, Aida Mary, Rodriguez Riera, Zalua, Lee, Yanick, Esteves, Luis Miguel, Normandeau, Charles‐Olivier, Fezas, Baptiste, Hernandez Saiz, Alejandro, Tournoux, François, Juneau, Daniel, DaSilva, Jean N.

“…Angiotensin II type 1 receptors (AT1R) blocker losartan is used in patients with renal and cardiovascular diseases. [18F]fluoropyridine‐losartan has shown…”
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Development of a novel [18F]fluorobenzyl derivative of the AT1 receptor antagonist Candesartan by Alonso Martinez, Luis Michel, DaSilva, Jean N.

“…Candesartan is a clinically approved angiotensin II type 1 receptor (AT1R)‐blocker that selectively binds AT1Rs in high affinity. We report here the…”
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Shifts in myocardial fatty acid and glucose metabolism in pulmonary arterial hypertension: a potential mechanism for a maladaptive right ventricular response by Ohira, Hiroshi, deKemp, Robert, Pena, Elena, Davies, Ross A, Stewart, Duncan J, Chandy, George, Contreras-Dominguez, Vladimir, Dennie, Carole, Mc Ardle, Brian, Mc Klein, Ran, Renaud, Jennifer M, DaSilva, Jean N, Pugliese, Carolyn, Dunne, Rosemary, Beanlands, Rob, Mielniczuk, Lisa M

“…We investigated the role of metabolic alterations in the development of a maladaptive right ventricular (RV) response in pulmonary arterial hypertension (PAH),…”
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Cardiac β-Adrenoceptor Expression Is Reduced in Zucker Diabetic Fatty Rats as Type-2 Diabetes Progresses by Haley, James M, Thackeray, James T, Thorn, Stephanie L, DaSilva, Jean N

“…Reduced cardiac β-adrenoceptor (β-AR) expression and cardiovascular dysfunction occur in models of hyperglycemia and hypoinsulinemia. Cardiac β-AR expression…”
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Effects of Short-Term Continuous Positive Airway Pressure on Myocardial Sympathetic Nerve Function and Energetics in Patients With Heart Failure and Obstructive Sleep Apnea: A Randomized Study by Hall, Allison B, Ziadi, Maria C, Leech, Judith A, Chen, Shin-Yee, Burwash, Ian G, Renaud, Jennifer, deKemp, Robert A, Haddad, Haissam, Mielniczuk, Lisa M, Yoshinaga, Keiichiro, Guo, Ann, Chen, Li, Walter, Olga, Garrard, Linda, DaSilva, Jean N, Floras, John S, Beanlands, Rob S.B

“…BACKGROUND—Heart failure with reduced ejection fraction and obstructive sleep apnea (OSA), 2 states of increased metabolic demand and sympathetic nervous…”
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Novel O-[11C]-methylated derivatives of the neprilysin inhibitor sacubitril: Radiosynthesis, autoradiography and plasma stability evaluation by Teyssier, Valentin R., Tournoux, François, Simard, José-Mathieu, Gaudette, Fleur, Boudjemeline, Mehdi, Petrenyov, Daniil R., DaSilva, Jean N.

“…The O-[11C]methylated derivatives of the clinically used neprilysin inhibitor (NEPi) sacubitril ([11C]SacOMe, (2R,4S)-ethyl…”
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Treatment with enalapril and not diltiazem ameliorated progression of chronic kidney disease in rats, and normalized renal AT1 receptor expression as measured with PET imaging by Ismail, Basma, deKemp, Rob A, Croteau, Etienne, Hadizad, Tayebeh, Burns, Kevin D, Beanlands, Rob S, DaSilva, Jean N

“…ACE inhibitors are considered first line of treatment in patients with many forms of chronic kidney disease (CKD). Other antihypertensives such as calcium…”
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Effects of an endothelin receptor antagonist, Macitentan, on right ventricular substrate utilization and function in a Sugen 5416/hypoxia rat model of severe pulmonary arterial hypertension by Drozd, Katarzyna, Ahmadi, Ali, Deng, Yupu, Jiang, Baohua, Petryk, Julia, Thorn, Stephanie, Stewart, Duncan, Beanlands, Rob, deKemp, Robert A., DaSilva, Jean N., Mielniczuk, Lisa M.

“…Altered myocardial energy metabolism has been linked to worsening of RV function in pulmonary arterial hypertension (PAH). The aim of this study was to…”
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Long-Term Follow-Up of Outcomes With F-18-Fluorodeoxyglucose Positron Emission Tomography Imaging-Assisted Management of Patients With Severe Left Ventricular Dysfunction Secondary to Coronary Disease by Mc Ardle, Brian, Shukla, Tushar, Nichol, Graham, deKemp, Robert A, Bernick, Jordan, Guo, Ann, Lim, Siok Ping, Davies, Ross A, Haddad, Haissam, Duchesne, Lloyd, Hendry, Paul, Masters, Roy, Ross, Heather, Freeman, Michael, Gulenchyn, Karen, Racine, Normand, Humen, Dennis, Benard, Francois, Ruddy, Terrence D, Chow, Benjamin J, Mielniczuk, Lisa, DaSilva, Jean N, Garrard, Linda, Wells, George A, Beanlands, Rob S B

“…Whether viability imaging can impact long-term patient outcomes is uncertain. The PARR-2 study (Positron Emission Tomography and Recovery Following…”
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Reliable quantification of myocardial sympathetic innervation and regional denervation using [11C]meta-hydroxyephedrine PET by Wu, Kai Yi, Zelt, Jason G.E., Wang, Tong, Dinculescu, Vincent, Miner, Robert, Lapierre, Catherine, Kaps, Nicole, Lavallee, Aaryn, Renaud, Jennifer M., Thackeray, James, Mielniczuk, Lisa M., Chen, Shin-Yee, Burwash, Ian G., DaSilva, Jean N., Beanlands, Rob S.B., deKemp, Robert A.

“…Purpose Cardiac sympathetic nervous system (SNS) dysfunction is associated with poor prognosis in chronic heart failure patients. This study characterized the…”
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Evaluation of the high affinity [18F]fluoropyridine-candesartan in rats for PET imaging of renal AT1 receptors by Abreu Diaz, Aida M., Drumeva, Gergana O., Laporte, Philippe, Alonso Martinez, Luis M., Petrenyov, Daniil R., Carrier, Jean-François, DaSilva, Jean N.

“…Alterations in the expression of the Angiotensin II type 1 receptors (AT1R) have been demonstrated in the development of several heart and renal diseases. The…”
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Characterization of 18F-FPyKYNE-Losartan for Imaging AT1 Receptors by Hachem, Maryam, Tiberi, Mario, Ismail, Basma, Hunter, Chad R, Arksey, Natasha, Hadizad, Tayebeh, Beanlands, Rob S, deKemp, Robert A, DaSilva, Jean N

“…Most physiologic effects of the renin angiotensin system (RAS) are mediated via the angiotensin (Ang) type 1 receptor (AT R). The F-FPyKYNE derivative of the…”
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Sympathetic nervous dysregulation in the absence of systolic left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia by Thackeray, James T, Radziuk, Jerry, Harper, Mary-Ellen, Suuronen, Erik J, Ascah, Kathryn J, Beanlands, Rob S, Dasilva, Jean N

“…Diabetes mellitus is strongly associated with cardiovascular dysfunction, derived in part from impairment of sympathetic nervous system signaling. Glucose,…”
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Effect of acute high-intensity interval exercise on a mouse model of doxorubicin-induced cardiotoxicity: a pilot study by Legault, Elise P, Ribeiro, Paula A B, Petrenyov, Daniil R, Drumeva, Gergana O, Leduc, Charles, Khullar, Sharmila, DaSilva, Jean N, Comtois, Alain Steve, Tournoux, François B

“…It is unknown whether high-intensity interval exercise (HIIE) may potentiate or attenuate the cardiotoxic effect of chemotherapy agents such as doxorubicin…”
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