Search Results - "DaCosta, Ralph S"

Multifunctional Albumin–MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and Enhance Radiation Response by Prasad, Preethy, Gordijo, Claudia R, Abbasi, Azhar Z, Maeda, Azusa, Ip, Angela, Rauth, Andrew Michael, DaCosta, Ralph S, Wu, Xiao Yu

“…Insufficient oxygenation (hypoxia), acidic pH (acidosis), and elevated levels of reactive oxygen species (ROS), such as H2O2, are characteristic abnormalities…”
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DORA-compliant measures of research quality and impact to assess the performance of researchers in biomedical institutions: Review of published research, international best practice and Delphi survey by Gagliardi, Anna R, Chen, Rob H C, Boury, Himani, Albert, Mathieu, Chow, James, DaCosta, Ralph S, Hoffman, Michael, Keshavarz, Behrang, Kontos, Pia, Liu, Jenny, McAndrews, Mary Pat, Protze, Stephanie

“…The San Francisco Declaration on Research Assessment (DORA) advocates for assessing biomedical research quality and impact, yet academic organizations continue…”
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Point-of-care autofluorescence imaging for real-time sampling and treatment guidance of bioburden in chronic wounds: first-in-human results by DaCosta, Ralph S, Kulbatski, Iris, Lindvere-Teene, Liis, Starr, Danielle, Blackmore, Kristina, Silver, Jason I, Opoku, Julie, Wu, Yichao Charlie, Medeiros, Philip J, Xu, Wei, Xu, Lizhen, Wilson, Brian C, Rosen, Cheryl, Linden, Ron

“…Traditionally, chronic wound infection is diagnosed by visual inspection under white light and microbiological sampling, which are subjective and suboptimal,…”
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Texture analysis of optical coherence tomography speckle for characterizing biological tissues in vivo by Lindenmaier, Andras A, Conroy, Leigh, Farhat, Golnaz, DaCosta, Ralph S, Flueraru, Costel, Vitkin, I Alex

“…We demonstrate a method for differentiating tissue disease states using the intrinsic texture properties of speckle in optical coherence tomography (OCT)…”
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Intraoperative fluorescence imaging with aminolevulinic acid detects grossly occult breast cancer: a phase II randomized controlled trial by Ottolino-Perry, Kathryn, Shahid, Anam, DeLuca, Stephanie, Son, Viktor, Sukhram, Mayleen, Meng, Fannong, Liu, Zhihui Amy, Rapic, Sara, Anantha, Nayana Thalanki, Wang, Shirley C, Chamma, Emilie, Gibson, Christopher, Medeiros, Philip J, Majeed, Safa, Chu, Ashley, Wignall, Olivia, Pizzolato, Alessandra, Rosen, Cheryl F, Teene, Liis Lindvere, Starr-Dunham, Danielle, Kulbatski, Iris, Panzarella, Tony, Done, Susan J, Easson, Alexandra M, Leong, Wey L, DaCosta, Ralph S

“…Re-excision due to positive margins following breast-conserving surgery (BCS) negatively affects patient outcomes and healthcare costs. The inability to…”
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In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model by Maeda, Azusa, PhD, Chen, Yonghong, MSc, MD, Bu, Jiachuan, MSc, Mujcic, Hilda, PhD, Wouters, Bradly G., PhD, DaCosta, Ralph S., PhD

“…Purpose To investigate the effect of high-dose irradiation on pancreatic tumor vasculature and microenvironment using in vivo imaging techniques. Methods and…”
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Improved detection of clinically relevant wound bacteria using autofluorescence image‐guided sampling in diabetic foot ulcers by Ottolino‐Perry, Kathryn, Chamma, Emilie, Blackmore, Kristina M, Lindvere‐Teene, Liis, Starr, Danielle, Tapang, Kim, Rosen, Cheryl F, Pitcher, Bethany, Panzarella, Tony, Linden, Ron, DaCosta, Ralph S

“…Clinical wound assessment involves microbiological swabbing of wounds to identify and quantify bacterial species, and to determine microbial susceptibility to…”
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Dual in vivo Photoacoustic and Fluorescence Imaging of HER2 Expression in Breast Tumors for Diagnosis, Margin Assessment, and Surgical Guidance by Maeda, Azusa, Bu, Jiachuan, Chen, Juan, Zheng, Gang, DaCosta, Ralph S.

“…Biomarker-specific imaging probes offer ways to improve molecular diagnosis, intraoperative margin assessment, and tumor resection. Fluorescence and…”
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Glucagon-Like-Peptide-2 Stimulates Lacteal Contractility and Enhances Chylomicron Transport in the Presence of an Intact Enteric Nervous System by Syed-Abdul, Majid Mufaqam, Tian, Lili, Samuel, Timothy, Wong, Alex, Hong, Young-Kwon, Dacosta, Ralph S., Lewis, Gary F.

“…Secretion and transport of intestinal chylomicrons (CMs) via lymphatics to the blood circulation is stimulated primarily by fat ingestion, whereas several…”
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Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology by Maeda, Azusa, Kulbatski, Iris, DaCosta, Ralph S.

“…Radiation therapy is an effective cancer treatment used in over 50% of cancer patients. Preclinical research in radiobiology plays a major role in influencing…”
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High Throughput Quantification of Protein Expression of Cancer Antigens in Tissue Microarray Using Quantum Dot Nanocrystals by Ghazani, Arezou A, Lee, Jeongjin A, Klostranec, Jesse, Xiang, Qing, Dacosta, Ralph S, Wilson, Brian C, Tsao, Ming S, Chan, Warren C. W

“…We developed and validated a novel method for quantifying protein expression of cancer tumors in an accurate, sensitive, and high throughput format. This…”
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A spinal cord window chamber model for in vivo longitudinal multimodal optical and acoustic imaging in a murine model by Figley, Sarah A, Chen, Yonghong, Maeda, Azusa, Conroy, Leigh, McMullen, Jesse D, Silver, Jason I, Stapleton, Shawn, Vitkin, Alex, Lindsay, Patricia, Burrell, Kelly, Zadeh, Gelareh, Fehlings, Michael G, DaCosta, Ralph S

“…In vivo and direct imaging of the murine spinal cord and its vasculature using multimodal (optical and acoustic) imaging techniques could significantly advance…”
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A handheld device for intra-cavity and ex vivo fluorescence imaging of breast conserving surgery margins with 5-aminolevulinic acid by Gibson, Christopher, Wang, Shirley C, Phoon, Arcturus, Thalanki Anantha, Nayana, Ottolino-Perry, Kathryn, Petropoulos, Stephen, Qureshi, Zuha, Subramanian, Vasanth, Shahid, Anam, O'Brien, Cristiana, Carcone, Steven, Chung, Suzanne, Tsui, Teresa, Son, Viktor, Sukhram, Mayleen, Meng, Fannong, Done, Susan J, Easson, Alexandra M, Cil, Tulin, Reedijk, Michael, Leong, Wey L, DaCosta, Ralph S

“…Visualization of cancer during breast conserving surgery (BCS) remains challenging; the BCS reoperation rate is reported to be 20-70% of patients. An urgent…”
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In vivo optical imaging of tumor and microvascular response to ionizing radiation by Maeda, Azusa, Leung, Michael K K, Conroy, Leigh, Chen, Yonghong, Bu, Jiachuan, Lindsay, Patricia E, Mintzberg, Shani, Virtanen, Carl, Tsao, Julissa, Winegarden, Neil A, Wang, Yanchun, Morikawa, Lily, Vitkin, I Alex, Jaffray, David A, Hill, Richard P, DaCosta, Ralph S

“…Radiotherapy is a widely used cancer treatment. However, understanding how ionizing radiation affects tumor cells and their vasculature, particularly at…”
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Customizable optical tissue phantom platform for characterization of fluorescence imaging device sensitivity by Gibson, Christopher, Phoon, Arcturus, DaCosta, Ralph S.

“…SignificanceOptical tissue phantoms serve as inanimate and stable reference materials used to calibrate, characterize, standardize, and test biomedical imaging…”
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Molecular Fluorescence Excitation–Emission Matrices Relevant to Tissue Spectroscopy by DaCosta, Ralph S., Andersson, Helene, Wilson, Brian C.

“…In vivo and ex vivo studies of fluorescence from endogenous and exogenous molecules in tissues and cells are common for applications such as detection or…”
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The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death by Stammes, Marieke A, Maeda, Azusa, Bu, Jiachuan, Scollard, Deborah A, Kulbatski, Iris, Medeiros, Philip J, Sinisi, Riccardo, Dubikovskaya, Elena A, Snoeks, Thomas J A, van Beek, Ermond R, Chan, Alan B, Löwik, Clemens W G M, DaCosta, Ralph S

“…Most effective antitumor therapies induce tumor cell death. Non-invasive, rapid and accurate quantitative imaging of cell death is essential for monitoring…”
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New optical technologies for earlier endoscopic diagnosis of premalignant gastrointestinal lesions by DACOSTA, RALPH S, WILSON, BRIAN C, MARCON, NORMAN E

“…Gastrointestinal malignancies continue to be the second leading cause of cancer‐related deaths in the developed world. The early detection and treatment of…”
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New insights into spatio-temporal dynamics of mesenchymal progenitor cell ingress during peri-implant wound healing: Provided by intravital imaging by Khosravi, Niloufar, DaCosta, Ralph S., Davies, John E.

“…Surface topography drives the success of orthopedic and dental implants placed in bone, by directing the biology occurring at the tissue-implant interface…”
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Porphyrin-Cross-Linked Hydrogel for Fluorescence-Guided Monitoring and Surgical Resection by Lovell, Jonathan F, Roxin, Aron, Ng, Kenneth K, Qi, Qiaochu, McMullen, Jesse D, DaCosta, Ralph S, Zheng, Gang

“…We demonstrate that porphyrins can be used as efficient cross-linkers to generate a new class of hydrogels with enabling optical properties. Tetracarboxylic…”
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