Search Results - "Da Tang, Li"

Identification of Cryptotanshinone as an Inhibitor of Oncogenic Protein Tyrosine Phosphatase SHP2 (PTPN11) by Liu, Wei, Yu, Bing, Xu, Gang, Xu, Wei-Ren, Loh, Mignon L, Tang, Li-Da, Qu, Cheng-Kui

“…Activating mutations of PTPN11 (encoding the SHP2 phosphatase) are associated with Noonan syndrome, childhood leukemias, and sporadic solid tumors. Virtual…”
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Docking and molecular dynamics simulations of peroxisome proliferator activated receptors interacting with pan agonist sodelglitazar by Liu, Xu-Yuan, Wang, Run-Ling, Xu, Wei-Ren, Tang, Li-Da, Wang, Shu-Qing, Chou, Kuo-Chen

“…PPAR (peroxisome proliferator-activated receptor) pan agonists play a critical role in treating metabolic diseases, especially the Type-2 diabetes mellitus…”
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SrCl2 as an efficient cocatalyst for acidic hydrolysis of methyl glycosides by Shi, Yong-Heng, Xie, Ya-Fei, Liu, Yu-Qiang, Wei, Qun-Chao, Xu, Wei-Ren, Tang, Li-Da, Zhao, Gui-Long

“…SrCl2 was found to be the most efficient cocatalyst for the acidic hydrolysis of methyl glycosides after 26 kinds of most representative metal salts were…”
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Design,synthesis and biological activity of cyclohexane-bearing C-glucoside derivatives as SGLT2 inhibitors by Zhang, Shuo, Wang, Yu-Li, Wei, Qun-Chao, Xu, Wei-Ren, Tang, Li-Da, Zhao, Gui-Long, Wang, Jian-Wu

“…Seven cyclohexane-bearing C-glucoside derivatives（7,9,12,13 and 17-19） were designed and synthesized as SGLT2 inhibitors starting from a potent SGLT2 inhibitor…”
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Design,synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors by Zhao, Wen Jing, Shi, Yong Heng, Zhao, Gui Long, Wang, Yu Li, Shao, Hua, Da Tang, Li, Wang, Jian Wu

“…A series of gem-dimethyl-bearing C-glucosides were designed and synthesized as SGLT2 inhibitors,with anhydrous aluminum chloride-mediated Friedel-Crafts…”
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Effect of human recombinant prourokinase(rhpro-UK) on thromboembolic stroke in rats by Hao, Chun-hua, Ding, Wen-xia, Sun, Qian, Li, Xin-xin, Wang, Wei-ting, Zhao, Zhuan-you, Tang, Li-da

“…We evaluated the efficacy and safety of human recombinant prourokinase ( rhpro-UK) on thromboembolic stroke in rats. 60 rats with thromboembolic stroke were…”
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Thrombolysis with rhPro-UK 3 to 6 hours after embolic stroke in rat by Hao, Chun-Hua, Ding, Wen-Xia, Sun, Qian, Li, Xin-Xin, Wang, Wei-Ting, Zhao, Zhuan-You, Tang, Li-Da

“…Objectives: To investigate the thrombolysis with recombinant human prourokinase (rhPro-UK) on thromboembolic stroke in rats at different therapeutic time…”
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Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies by Yu, Bing, Liu, Wei, Yu, Wen-Mei, Loh, Mignon L, Alter, Shawn, Guvench, Olgun, Mackerell, Jr, Alexander D, Tang, Li-Da, Qu, Cheng-Kui

“…Activating mutations in PTPN11 (encoding SHP2), a protein tyrosine phosphatase (PTP) that plays an overall positive role in growth factor and cytokine…”
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Correlation of Metabolism, Metabolomics, and Metabonomics by Tang, Li-da

“…In this issue,CHM published two reviews on drug metabolism of Chinese herbal medicines.Three key words have been found,they are metabolism,metabolomics,and…”
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Design, synthesis and antitumor activity of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinase by Yu, Bing, Tang, Li-da, Li, Yi-liang, Song, Shu-hui, Ji, Xiao-liang, Lin, Mu-sen, Wu, Chun-Fu

“…A series of 4-aminoquinazoline derivatives based inhibitors of VEGFR-2 tyrosine kinases were synthesized and identified. Some of them exhibited significant…”
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Effects of Puerarin on Experimental Model of Retinal Vein Occlusion in Rats by Hao, Chun-hua, Wang, Wei-ting, Shao, Ming-xiang, Zhao, Zhuan-you, Tang, Li-da

“…Objective To establish a model of retinal vein occlusion（RVO）in rats and to study the effect of puerarin on ischemic retinal disease and the corresponding…”
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Corrigendum to “Effects of total iridoid glycosides of Picrorhiza scrophulariiflora against non-alcoholic steatohepatitis rats induced by high-fat and high-sugar diet through regulation of lipid metabolism” [Chin Herb Med 12 (2019) 67–72] by Xu, Xu, Wang, Wei-ting, Zhao, Zhuan-you, Xi, Wen-gong, Yu, Bing, Hao, Chun-hua, Li, Xin, Hou, Wen-bin, Tang, Li-da

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Corrigendum to “Neuroprotective effect of Sanqi Tongshuan Tablets on sequelae post-stroke in rats” [Chinese Herbal Medicines 11 (2019) 45–51] by Wang, Wei-ting, Hao, Chun-hua, Zhang, Shao-xiang, Zhang, Xiang-hua, Guo, Feng, Sun, Shuang-yong, Zhang, Rui, Zhao, Zhuan-you, Tang, Li-da

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Effects of total iridoid glycosides of Picrorhiza scrophulariiflora against non-alcoholic steatohepatitis rats induced by high-fat and high-sugar diet through regulation of lipid metabolism by Xu, Xu, Wang, Wei-ting, Zhao, Zhuan-you, Xi, Wen-gong, Yu, Bing, Hao, Chun-hua, Li, Xin, Hou, Wen-bin, Tang, Li-da

“…To investigate the therapeutic effect of total iridoid glycosides of Picrorhiza scrophulariiflora (TIGP) on non-alcoholic steatohepatitis (NASH). SD rats were…”
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Neuroprotective effect of Sanqi Tongshuan Tablets on sequelae post-stroke in rats by Wang, Wei-ting, Hao, Chun-hua, Zhang, Shao-xiang, Zhang, Xiang-hua, Guo, Feng, Sun, Shuang-yong, Zhang, Rui, Zhao, Zhuan-you, Tang, Li-da

“…To identify the therapeutic effect and possible mechanisms of Chinese medicine Sanqi Tongshuan Tablets (SQTS) on sequelae post-stroke in rats. The rat cerebral…”
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Impact of Body Mass Index on the Clinical Outcomes after Percutaneous Coronary Intervention in Patients ≥75 Years Old by He, Pei-Yuan, Yang, Yue-Jin, Qiao, Shu-Bin, Xu, Bo, Yao, Min, Wu, Yong-Jian, Wu, Yuan, Yuan, Jin-Qing, Chen, Jue, Liu, Hai-Bo, Dai, Jun, Li, Wei, Tang, Yi-Da, Yang, Jin-Gang, Gao, Run-Lin

“…Background：The impact of body mass index （BMI） on the clinical outcomes after percutaneous coronary intervention （PCI） in patients ≥75 years old remained…”
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Orphan G protein-coupled receptors （GPCRs）： biological functions and potential drug targets by Xiao-long TANG Ying WANG Da-li LI Jian LUO Ming-yao LIU

“…The superfamily of G protein-coupled receptors （GPCRs） includes at least 800 seven-transmembrane receptors that participate in diverse physiological and…”
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Measurement of Reference Radiation Spectrum of Isotopic Neutron Source and Analysis of Simulated Neutron Spectrum by LI Ziping;TANG Zhihui;LI Da;FENG Mei;JIANG Hong;LI Duohong;ZHOU Zhibo

“…The neutron reference radiation field of different components is the basic condition for the performance test of neutron shielding materials. In order to…”
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Beneficial effects of N‐acetylcysteine and cysteine in stunned myocardium in perfused rat heart by Tang, Li‐Da, Sun, Jian‐Zhong, Wu, Ke, Sun, Cun‐Pu, Tang, Zhong‐Ming

“…1 The objective of this study was to evaluate the effects of three sulphydryl (SH) compounds, N‐acetylcysteine (NAC), cysteine (Cys) and cystamine, on…”
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APPLICATION OF TIME-VARYING VISCOUS GROUT IN GRAVEL- FOUNDATION ANTI-SEEPAGE TREATMENT by CHENG, Peng-da, LI, Lu, TANG, Ju, WANG, Dao-zeng

“…The time-varying viscosity of common grout and the controllable grout are measured with a rotation viscometer in experiments. The time-varying viscosity of…”
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