Search Results - "Da Silva Padilha, Miguel"
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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
Published in Nature communications (02-02-2023)“…Amyloid-like aggregates of the microtubule-associated protein Tau are associated with several neurodegenerative disorders including Alzheimer’s disease. The…”
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Journal Article -
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Neuroprotective effects of hepatoma-derived growth factor in models of Huntington's disease
Published in Life science alliance (01-11-2023)“…Huntington's disease (HD) is a movement disorder caused by a mutation in the Huntingtin gene that leads to severe neurodegeneration. Molecular mechanisms of HD…”
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Journal Article -
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Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity
Published in Life science alliance (01-03-2022)“…The autophagy-lysosomal pathway is impaired in many neurodegenerative diseases characterized by protein aggregation, but the link between aggregation and…”
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Journal Article -
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Characterization of a Novel Mouse Model for Neurodegeneration
Published 01-01-2020“…Doenças neurodegenerativas são enfermidades devastadoras, responsáveis pela perda de células do sistema nervoso central. Este grupo de doenças crónicas e…”
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Dissertation