Search Results - "Da Silva Cruz, Elisabete"

Role of Integrins in Resistance to Therapies Targeting Growth Factor Receptors in Cancer by Cruz da Silva, Elisabete, Dontenwill, Monique, Choulier, Laurence, Lehmann, Maxime

“…Integrins contribute to cancer progression and aggressiveness by activating intracellular signal transduction pathways and transducing mechanical tension…”
Get full text

Direct Zeptomole Detection of RNA Biomarkers by Ultrabright Fluorescent Nanoparticles on Magnetic Beads by Cruz Da Silva, Elisabete, Gaki, Paraskevi, Flieg, Fabien, Messmer, Melanie, Gucciardi, Floriane, Markovska, Yevheniia, Reisch, Andreas, Fafi‐Kremer, Samira, Pfeffer, Sébastien, Klymchenko, Andrey S.

“…Nucleic acids are important biomarkers in cancer and viral diseases. However, their ultralow concentration in biological/clinical samples makes direct target…”
Get full text

Gefitinib induces EGFR and α5β1 integrin co-endocytosis in glioblastoma cells by Blandin, Anne-Florence, Cruz Da Silva, Elisabete, Mercier, Marie-Cécile, Glushonkov, Oleksandr, Didier, Pascal, Dedieu, Stéphane, Schneider, Cristophe, Devy, Jessica, Etienne-Selloum, Nelly, Dontenwill, Monique, Choulier, Laurence, Lehmann, Maxime

“…Overexpression of EGFR drives glioblastomas (GBM) cell invasion but these tumours remain resistant to EGFR-targeted therapies such as tyrosine kinase…”
Get full text

Bioimaging Nucleic-Acid Aptamers with Different Specificities in Human Glioblastoma Tissues Highlights Tumoral Heterogeneity by Cruz Da Silva, Elisabete, Foppolo, Sophie, Lhermitte, Benoît, Ingremeau, Marina, Justiniano, Hélène, Klein, Lorraine, Chenard, Marie-Pierre, Vauchelles, Romain, Abdallah, Basma, Lehmann, Maxime, Etienne-Selloum, Nelly, Dontenwill, Monique, Choulier, Laurence

“…Nucleic-acid aptamers are of strong interest for diagnosis and therapy. Compared with antibodies, they are smaller, stable upon variations in temperature, easy…”
Get full text

Role of Endocytosis Proteins in Gefitinib-Mediated EGFR Internalisation in Glioma Cells by Cruz Da Silva, Elisabete, Choulier, Laurence, Thevenard-Devy, Jessica, Schneider, Christophe, Carl, Philippe, Rondé, Philippe, Dedieu, Stéphane, Lehmann, Maxime

“…EGFR (epidermal growth factor receptor), a member of the ErbB tyrosine kinase receptor family, is a clinical therapeutic target in numerous solid tumours. EGFR…”
Get full text

A Systematic Review of Glioblastoma-Targeted Therapies in Phases II, III, IV Clinical Trials by Cruz Da Silva, Elisabete, Mercier, Marie-Cécile, Etienne-Selloum, Nelly, Dontenwill, Monique, Choulier, Laurence

“…Glioblastoma (GBM), the most frequent and aggressive glial tumor, is currently treated as first line by the Stupp protocol, which combines, after surgery,…”
Get full text

Amplified Fluorescence in Situ Hybridization by Small and Bright Dye-Loaded Polymeric Nanoparticles by Egloff, Sylvie, Melnychuk, Nina, Cruz Da Silva, Elisabete, Reisch, Andreas, Martin, Sophie, Klymchenko, Andrey S

“…Detection and imaging of RNA at the single-cell level is of utmost importance for fundamental research and clinical diagnostics. Current techniques of RNA…”
Get full text

Long‐Range Energy Transfer between Dye‐Loaded Nanoparticles: Observation and Amplified Detection of Nucleic Acids by Biswas, Deep Sekhar, Gaki, Paraskevi, Cruz Da Silva, Elisabete, Combes, Antoine, Reisch, Andreas, Didier, Pascal, Klymchenko, Andrey S.

“…Förster resonance energy transfer (FRET) is essential in optical materials for light‐harvesting, photovoltaics, and biosensing, but its operating range is…”
Get full text

Fluorescent macrocycle-dye-anchor conjugates for sensing phospholipids in biomembranes by Oshchepkov, Alexander S., Cruz Da Silva, Elisabete, Morozov, Boris S., Aparin, Ilya O., Kataev, Evgeny A., Klymchenko, Andrey S.

“…Negatively charged phospholipids can serve as biomarkers for a number of biological processes allowing detection of apoptosis in animal cells, drug-induced…”
Get full text

Amplified Fluorescence in Situ Hybridization by Small and Bright Dye-Loaded Polymeric Nanoparticles by Egloff, Sylvie, Melnychuk, Nina, Cruz da Silva, Elisabete, Reisch, Andreas, Martin, Sophie, Klymchenko, Andrey S

“…Detection and imaging of RNA at the single-cell level is of utmost importance for fundamental research and clinical diagnostics. Current techniques of RNA…”
Get full text

Biotinylated Fluorescent Polymeric Nanoparticles for Enhanced Immunostaining by Yudhistira, Tesla, Da Silva, Elisabete Cruz, Combes, Antoine, Lehmann, Maxime, Reisch, Andreas, Klymchenko, Andrey S.

“…The performance of fluorescence immunostaining is physically limited by the brightness of organic dyes, whereas fluorescence labeling with multiple dyes per…”
Get full text

RNA Aptamers Targeting Integrin α5β1 as Probes for Cyto- and Histofluorescence in Glioblastoma by Fechter, Pierre, Cruz Da Silva, Elisabete, Mercier, Marie-Cécile, Noulet, Fanny, Etienne-Seloum, Nelly, Guenot, Dominique, Lehmann, Maxime, Vauchelles, Romain, Martin, Sophie, Lelong-Rebel, Isabelle, Ray, Anne-Marie, Seguin, Cendrine, Dontenwill, Monique, Choulier, Laurence

“…Nucleic acid aptamers are often referred to as chemical antibodies. Because they possess several advantages, like their smaller size, temperature stability,…”
Get full text

Ascites microenvironment conditions the peritoneal pre-metastatic niche to promote the implantation of ovarian tumor spheroids: Involvement of fibrinogen/fibrin and αV and α5β1 integrins by Laurent-Issartel, Carine, Landras, Alexandra, Agniel, Rémy, Giffard, Florence, Blanc-Fournier, Cécile, Da Silva Cruz, Elisabete, Habes, Chahrazed, Leroy-Dudal, Johanne, Carreiras, Franck, Kellouche, Sabrina

“…At least one-third of patients with epithelial ovarian cancer (OC) present ascites at diagnosis and almost all have ascites at recurrence especially because of…”
Get full text

Integrin alpha5beta1 and Resistance to Cancer Therapies: Role of Endocytosis in Resistance to Gefitinib by Silva, Elisabete Cruz da

“…Glioblastoma is an aggressive, invasive and resistant brain cancer. Despite the promisor role of EGFR, targeted therapies failed without giving insights about…”
Get full text