Search Results - "Da Silva, Claudia"

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept by Almeida, Afonso R, Correia, Daniel V, Fernandes-Platzgummer, Ana, da Silva, Cláudia L, da Silva, Maria Gomes, Anjos, Diogo Remechido, Silva-Santos, Bruno

“…The Vδ1 subset of γδ T lymphocytes is a promising candidate for cancer immunotherapy, but the lack of suitable expansion/differentiation methods has precluded…”
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Extracellular matrix decorated polycaprolactone scaffolds for improved mesenchymal stem/stromal cell osteogenesis towards a patient‐tailored bone tissue engineering approach by Silva, João C., Carvalho, Marta S., Udangawa, Ranodhi N., Moura, Carla S., Cabral, Joaquim M. S., L. da Silva, Cláudia, Ferreira, Frederico Castelo, Vashishth, Deepak, Linhardt, Robert J.

“…The clinical demand for tissue‐engineered bone is growing due to the increase of non‐union fractures and delayed healing in an aging population. Herein, we…”
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Biomimetic matrices for rapidly forming mineralized bone tissue based on stem cell-mediated osteogenesis by Carvalho, Marta S., Poundarik, Atharva A., Cabral, Joaquim M. S., da Silva, Cláudia L., Vashishth, Deepak

“…Bone regeneration, following fracture, relies on autologous and allogenic bone grafts. However, majority of fracture population consists of older individuals…”
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Scalable microcarrier-based manufacturing of mesenchymal stem/stromal cells by de Soure, António M., Fernandes-Platzgummer, Ana, da Silva, Cláudia L., Cabral, Joaquim M.S.

“…•Comprehensive overview on the manufacturing of human mesenchymal stem/stromal cells.•Bioprocess engineering approaches combining bioreactors with microcarrier…”
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Mesenchymal stromal cells induce regulatory T cells via epigenetic conversion of human conventional CD4 T cells in vitro by Azevedo, Rita, Minskaia, Ekaterina, Fernandes-Platzgummer, Ana, Vieira, Ana, Martins Lobato da Silva, Cláudia Alexandra, Cabral, Joaquim M.S., Lacerda, João

“…© 2020 The Authors. S TEM CELLS published by Wiley Periodicals LLC on behalf of AlphaMed Press. This is an open access article under the terms of the Creative…”
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Bone Matrix Non-Collagenous Proteins in Tissue Engineering: Creating New Bone by Mimicking the Extracellular Matrix by Carvalho, Marta S, Cabral, Joaquim M S, da Silva, Cláudia L, Vashishth, Deepak

“…Engineering biomaterials that mimic the extracellular matrix (ECM) of bone is of significant importance since most of the outstanding properties of the bone…”
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A xenogeneic-free bioreactor system for the clinical-scale expansion of human mesenchymal stem/stromal cells by dos Santos, Francisco, Campbell, Andrew, Fernandes-Platzgummer, Ana, Andrade, Pedro Z., Gimble, Jeffrey M., Wen, Yuan, Boucher, Shayne, Vemuri, Mohan C., da Silva, Cláudia L., Cabral, Joaquim M.S.

“…ABSTRACT The large cell doses (>1 × 106 cells/kg) used in clinical trials with mesenchymal stem/stromal cells (MSC) will require an efficient production…”
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Synergistic effect of extracellularly supplemented osteopontin and osteocalcin on stem cell proliferation, osteogenic differentiation, and angiogenic properties by Carvalho, Marta S, Cabral, Joaquim MS, da Silva, Cláudia L, Vashishth, Deepak

“…A high demand for functional bone grafts is being observed worldwide, especially due to the increased life expectancy. Osteoinductive components should be…”
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Tridimensional configurations of human mesenchymal stem/stromal cells to enhance cell paracrine potential towards wound healing processes by Costa, Marta H.G., McDevitt, Todd C., Cabral, Joaquim M.S., da Silva, Cláudia L., Ferreira, Frederico Castelo

“…•Side-by-side comparison of three 3D configurations vs 2D monolayer MSC cultures.•3D MSC cultures include spheroids and alginate encapsulated spheroids or…”
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Optimized operation of a controlled stirred tank reactor system for the production of mesenchymal stromal cells and their extracellular vesicles by Fernandes‐Platzgummer, Ana, Cunha, Raquel, Morini, Sara, Carvalho, Marta, Moreno‐Cid, Juan, García, Carmen, Cabral, Joaquim M. S., Silva, Cláudia L.

“…The therapeutic effects of human mesenchymal stromal cells (MSC) have been attributed mostly to their paracrine activity, exerted through small‐secreted…”
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Chondrogenic differentiation of mesenchymal stem/stromal cells on 3D porous poly (ε-caprolactone) scaffolds: Effects of material alkaline treatment and chondroitin sulfate supplementation by Moura, Carla Sofia, Silva, João Carlos, Faria, Sofia, Fernandes, Paulo Rui, da Silva, Cláudia Lobato, Cabral, Joaquim Manuel Sampaio, Linhardt, Robert, Bártolo, Paulo Jorge, Ferreira, Frederico Castelo

“…Cartilage defects resultant from trauma or degenerative diseases (e.g., osteoarthritis) can potentially be repaired using tissue engineering (TE) strategies…”
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Differentiation of human umbilical cord matrix mesenchymal stem cells into neural-like progenitor cells and maturation into an oligodendroglial-like lineage by Leite, Cristiana, Silva, N Tatiana, Mendes, Sandrine, Ribeiro, Andreia, de Faria, Joana Paes, Lourenço, Tânia, dos Santos, Francisco, Andrade, Pedro Z, Cardoso, Carla M P, Vieira, Margarida, Paiva, Artur, da Silva, Cláudia L, Cabral, Joaquim M S, Relvas, João B, Grãos, Mário

“…Mesenchymal stem cells (MSCs) are viewed as safe, readily available and promising adult stem cells, which are currently used in several clinical trials…”
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Loss and rescue of osteocalcin and osteopontin modulate osteogenic and angiogenic features of mesenchymal stem/stromal cells by Carvalho, Marta S., Silva, João C., Hoff, Christopher M., Cabral, Joaquim M. S., Linhardt, Robert J., Silva, Cláudia L., Vashishth, Deepak

“…Noncollagenous proteins in the bone extracellular matrix, such as osteocalcin (OC) and osteopontin (OPN), inherent to evolution of bone as a skeletal tissue,…”
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Stirred tank bioreactor culture combined with serum-/xenogeneic-free culture medium enables an efficient expansion of umbilical cord-derived mesenchymal stem/stromal cells by Mizukami, Amanda, Fernandes-Platzgummer, Ana, Carmelo, Joana G., Swiech, Kamilla, Covas, Dimas T., Cabral, Joaquim M. S., da Silva, Cláudia L.

“…Mesenchymal stem/stromal cells (MSC) are being widely explored as promising candidates for cell‐based therapies. Among the different human MSC origins…”
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Cultured cell‐derived extracellular matrices to enhance the osteogenic differentiation and angiogenic properties of human mesenchymal stem/stromal cells by Carvalho, Marta S., Silva, João C., Cabral, Joaquim M.S., Silva, Cláudia L., Vashishth, Deepak

“…Cell‐derived extracellular matrix (ECM) consists of a complex assembly of fibrillary proteins, matrix macromolecules, and associated growth factors that mimic…”
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Human mesenchymal stem cell expression program upon extended ex-vivo cultivation, as revealed by 2-DE-based quantitative proteomics by Madeira, Andreia, da Silva, Cláudia L, dos Santos, Francisco, Camafeita, Emilio, Cabral, Joaquim M S, Sá-Correia, Isabel

“…Human mesenchymal stem cells (MSC) have been on the focus of intense clinical-oriented research due to their multilineage differentiation potential and…”
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Modulation of the in vitro angiogenic potential of human mesenchymal stromal cells from different tissue sources by Pinto, Diogo S., Ahsan, Tabassum, Serra, Joana, Fernandes‐Platzgummer, Ana, Cabral, Joaquim M. S., Silva, Cláudia L.

“…Mesenchymal stromal cells (MSCs) have been widely exploited for the treatment of several conditions due to their intrinsic regenerative and immunomodulatory…”
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The evening crepuscular host-seeking activity of Anopheles mosquitoes in northeast Brazil by Costa-Neta, Benedita Maria, Francisca Claudia da Silva, de Sousa, Eudimara Carvalho, de Araújo, Joany da, Costa Viana, Brito, Jefferson Mesquita, Silva, Francinaldo Soares

“…Studies on the timing of anopheline host-seeking are important for understanding mosquito ecology, behaviors, and possible role in disease transmission. To…”
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Successful isolation and ex vivo expansion of human mesenchymal stem/stromal cells obtained from different synovial tissue‐derived (biopsy) samples by Ferro, Tiago, Santhagunam, Aruna, Madeira, Catarina, Salgueiro, João B., Silva, Cláudia L., Cabral, Joaquim M. S.

“…Mesenchymal stromal cells (MSC) isolated from synovial tissues constitute a novel source of stem‐like cells with promising applications in cartilage…”
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The Cycle of Violence: Examining Attitudes Toward and Experiences of Corporal Punishment in a Representative German Sample by Witt, Andreas, Fegert, Jörg M., Rodens, Klaus P., Brähler, Elmar, Lührs Da Silva, Claudia, Plener, Paul L.

“…The use of corporal punishment (CP) is controversial despite the negative consequences of its use that have been documented. Consequences include the use of CP…”
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