Search Results - "Da Silva, Afitz"

Design of Potent Mannose 6-Phosphate Analogues for the Functionalization of Lysosomal Enzymes To Improve the Treatment of Pompe Disease by El Cheikh, Khaled, Basile, Ilaria, Da Silva, Afitz, Bernon, Coralie, Cérutti, Pierre, Salgues, Frédéric, Perez, Marc, Maynadier, Marie, Gary-Bobo, Magali, Caillaud, Catherine, Cérutti, Martine, Garcia, Marcel, Morère, Alain

“…Improving therapeutics delivery in enzyme replacement therapy (ERT) for lysosomal storage disorders is a challenge. Herein, we present the synthesis of novel…”
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Mannose 6‐phosphonate labelling: A key for processing the therapeutic enzyme in Pompe disease by Godefroy, Anastasia, Daurat, Morgane, Da Silva, Afitz, Basile, Ilaria, El Cheikh, Khaled, Caillaud, Catherine, Sacconi, Sabrina, Schoser, Benedikt, Charbonné, Henry‐Vincent, Gary‐Bobo, Magali, Morère, Alain, Garcia, Marcel, Maynadier, Marie

“…In the search of a better enzyme therapy in Pompe disease, the conjugation of mannose 6‐phosphonates to the recombinant enzyme appeared as an enhancer of its…”
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Sialic acid catabolism by N-acetylneuraminate pyruvate lyase is essential for muscle function by Wen, Xiao-Yan, Tarailo-Graovac, Maja, Brand-Arzamendi, Koroboshka, Willems, Anke, Rakic, Bojana, Huijben, Karin, Da Silva, Afitz, Pan, Xuefang, El-Rass, Suzan, Ng, Robin, Selby, Katheryn, Philip, Anju Mary, Yun, Junghwa, Ye, X Cynthia, Ross, Colin J, Lehman, Anna M, Zijlstra, Fokje, Abu Bakar, N, Drögemöller, Britt, Moreland, Jacqueline, Wasserman, Wyeth W, Vallance, Hilary, van Scherpenzeel, Monique, Karbassi, Farhad, Hoskings, Martin, Engelke, Udo, de Brouwer, Arjan, Wevers, Ron A, Pshezhetsky, Alexey V, van Karnebeek, Clara Dm, Lefeber, Dirk J

“…Sialic acids are important components of glycoproteins and glycolipids essential for cellular communication, infection, and metastasis. The importance of…”
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Sequential delivery of synergistic drugs by silica nanocarriers for enhanced tumour treatment by Birault, Albane, Giret, Simon, Théron, Christophe, Gallud, Audrey, Da Silva, Afitz, Durand, Denis, Nguyen, Christophe, Bettache, Nadir, Gary-Bobo, Magali, Bartlett, John R, Wong Chi Man, Michel, Carcel, Carole

“…Herein hybrid silica nanoparticles have been engineered to direct the sequential delivery of multiple chemotherapeutic drugs in response to external stimuli…”
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Biological Fate of Fe₃O₄ Core-Shell Mesoporous Silica Nanoparticles Depending on Particle Surface Chemistry by Rascol, Estelle, Daurat, Morgane, Da Silva, Afitz, Maynadier, Marie, Dorandeu, Christophe, Charnay, Clarence, Garcia, Marcel, Lai-Kee-Him, Joséphine, Bron, Patrick, Auffan, Mélanie, Liu, Wei, Angeletti, Bernard, Devoisselle, Jean-Marie, Guari, Yannick, Gary-Bobo, Magali, Chopineau, Joël

“…The biological fate of nanoparticles (NPs) for biomedical applications is highly dependent of their size and charge, their aggregation state and their surface…”
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Biosafety of Mesoporous Silica Nanoparticles by Rascol, Estelle, Pisani, Cédric, Dorandeu, Christophe, Nyalosaso, Jeff L, Charnay, Clarence, Daurat, Morgane, Da Silva, Afitz, Devoisselle, Jean-Marie, Gaillard, Jean-Charles, Armengaud, Jean, Prat, Odette, Maynadier, Marie, Gary-Bobo, Magali, Garcia, Marcel, Chopineau, Joël, Guari, Yannick

“…Careful analysis of any new nanomedicine device or disposal should be undertaken to comprehensively characterize the new product before application, so that…”
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Stealth Biocompatible Si-Based Nanoparticles for Biomedical Applications by Liu, Wei, Chaix, Arnaud, Gary-Bobo, Magali, Angeletti, Bernard, Masion, Armand, Da Silva, Afitz, Daurat, Morgane, Lichon, Laure, Garcia, Marcel, Morère, Alain, El Cheikh, Khaled, Durand, Jean-Olivier, Cunin, Frédérique, Auffan, Mélanie

“…A challenge regarding the design of nanocarriers for drug delivery is to prevent their recognition by the immune system. To improve the blood residence time…”
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Efficient therapy for refractory Pompe disease by mannose 6-phosphate analogue grafting on acid α-glucosidase by Basile, Ilaria, Da Silva, Afitz, El Cheikh, Khaled, Godefroy, Anastasia, Daurat, Morgane, Harmois, Alice, Perez, Marc, Caillaud, Catherine, Charbonné, Henry-Vincent, Pau, Bernard, Gary-Bobo, Magali, Morère, Alain, Garcia, Marcel, Maynadier, Marie

“…Pompe disease is a rare disorder due to deficiency of the acid α-glucosidase (GAA) treated by enzyme replacement therapy. The present authorized treatment with…”
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Biocompatible Periodic Mesoporous Ionosilica Nanoparticles with Ammonium Walls: Application to Drug Delivery by Bouchal, Roza, Daurat, Morgane, Gary-Bobo, Magali, Da Silva, Afitz, Lesaffre, Leïla, Aggad, Dina, Godefroy, Anastasia, Dieudonné, Philippe, Charnay, Clarence, Durand, Jean-Olivier, Hesemann, Peter

“…Periodic mesoporous ionosilica nanoparticles with ammonium walls were synthesized exclusively from a trisilylated ammonium precursor. The nanoparticles display…”
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Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: Drug delivery, one and two-photon photodynamic therapy by Gary-Bobo, Magali, Mir, Youssef, Rouxel, Cédric, Brevet, David, Hocine, Ouahiba, Maynadier, Marie, Gallud, Audrey, Da Silva, Afitz, Mongin, Olivier, Blanchard-Desce, Mireille, Richeter, Sébastien, Loock, Bernard, Maillard, Philippe, Morère, Alain, Garcia, Marcel, Raehm, Laurence, Durand, Jean-Olivier

“…In this work, we focused on mesoporous silica nanoparticles (MSN) for one photon excitated photodynamic therapy (OPE-PDT) combined with drug delivery and…”
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N -acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function by Da Silva, Afitz, Dort, Junio, Orfi, Zakaria, Pan, Xuefang, Huang, Sjanie, Kho, Ikhui, Heckel, Emilie, Muscarnera, Giacomo, van Vliet, Patrick Piet, Sturiale, Luisa, Messina, Angela, Romeo, Donata Agata, van Karnebeek, Clara D M, Wen, Xiao-Yan, Hinek, Aleksander, Molina, Thomas, Andelfinger, Gregor, Ellezam, Benjamin, Yamanaka, Yojiro, Olivos, Hernando J, Morales, Carlos R, Joyal, Jean-Sébastien, Lefeber, Dirk J, Garozzo, Domenico, Dumont, Nicolas A, Pshezhetsky, Alexey V

“…Deleterious variants in acetylneuraminate pyruvate lyase (NPL) cause skeletal myopathy and cardiac edema in humans and zebrafish, but its physiological role…”
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Design of Potent Mannose 6-Phosphate Analogues for the Functionalization of Lysosomal Enzymes To Improve the Treatment of Pompe Disease by El Cheikh, Khaled, Basile, Ilaria, Da Silva, Afitz, Bernon, Coralie, Cérutti, Pierre, Salgues, Frédéric, Perez, Marc, Maynadier, Marie, Gary-Bobo, Magali, Caillaud, Catherine, Cérutti, Martine, Garcia, Marcel, Morère, Alain

“…Improving therapeutics delivery in enzyme replacement therapy (ERT) for lysosomal storage disorders is a challenge. Herein, we present the synthesis of novel…”
Get full text