Search Results - "Da Settimo, A"

[1,2,4]Triazino[4,3-a]benzimidazole Acetic Acid Derivatives:  A New Class of Selective Aldose Reductase Inhibitors by Da Settimo, Federico, Primofiore, Giampaolo, Da Settimo, Antonio, La Motta, Concettina, Taliani, Sabrina, Simorini, Francesca, Novellino, Ettore, Greco, Giovanni, Lavecchia, Antonio, Boldrini, Enrico

“…Acetic acid derivatives of [1,2,4]triazino[4,3-a]benzimidazole (TBI) were synthesized and tested in vitro and in vivo as a novel class of aldose reductase…”
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Novel, Highly Potent Aldose Reductase Inhibitors:  Cyano(2-oxo-2,3-dihydroindol-3-yl)acetic Acid Derivatives by Da Settimo, Federico, Primofiore, Giampaolo, Da Settimo, Antonio, La Motta, Concettina, Simorini, Francesca, Novellino, Ettore, Greco, Giovanni, Lavecchia, Antonio, Boldrini, Enrico

“…Cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives were synthesized and tested as a novel class of aldose reductase (ALR2) inhibitors. Each compound was…”
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N‘-Phenylindol-3-ylglyoxylohydrazide Derivatives:  Synthesis, Structure−Activity Relationships, Molecular Modeling Studies, and Pharmacological Action on Brain Benzodiazepine Receptors by Da Settimo, Antonio, Primofiore, Giampaolo, Da Settimo, Federico, Marini, Anna Maria, Novellino, Ettore, Greco, Giovanni, Gesi, Marco, Martini, Claudia, Giannaccini, Gino, Lucacchini, Antonio

“…A series of N‘-phenylindol-3-ylglyoxylohydrazides, isosters of the N-benzylindol-3-ylglyoxylamide derivatives previously described by us, were synthesized and…”
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Synthesis of pyrimido[1,2-a]benzimidazol-4(10H)-one derivatives and evaluation of their interactions with DNA by Da Settimo, A., Primofiore, G., Da Settimo, F., Marini, A. M., Taliani, S., Salerno, S., Dalla Via, L.

“…The synthesis of new derivatives of the planar tricyclic pyrimido[1,2‐a]benzimidazole system featuring protonable side chains in the 3 and/or 10 positions is…”
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Synthesis of pyrrolo[3,4- c]pyridine derivatives possessing an acid group and their in vitro and in vivo evaluation as aldose reductase inhibitors by Da Settimo, A, Primofiore, G, Da Settimo, F, Simorini, F, La Motta, C, Martinelli, A, Boldrini, E

“…Derivatives of [pyrrolo[3,4- c]pyridin-1,3(2 H)-dion-2-yl] alkanoic acids were prepared and their in vitro aldose reductase inhibitory activity was tested on…”
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Synthesis and evaluation of aminoadamantane derivatives for in vitro anti-HIV and antitumor activities by da Settimo, A, Marini, A M, Primofiore, G, Da Settimo, F

“…The synthesis of a series of 2-aminobenzimidazole and indole amide derivatives containing the adamantyl moiety is described. The compounds, evaluated for in…”
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Acid derivatives of benzisothiazole-1,1-dioxide as inhibitors of rat lens aldose reductase by Da Settimo, A, Primofiore, G, La Motta, C, Da Settimo, F, Simorini, F, Boldrini, E, Bianchini, P

“…A number of 6-substituted 1, 2-benzisothiazole-1, 1-dioxide alkanoic acids were synthesized and evaluated for crude rat lens aldose reductase inhibitory…”
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Synthesis and antiinflammatory properties of 2-aminobenzimidazole derivatives by Da Settimo, A, Primofiore, G, Da Settimo, F, Marini, A M

“…Several 1-alkyl or 1-aralkyl substituted 2-aminobenzimidazole derivatives, bearing an acetic or acetohydroxamic group at 3-position, were synthesized. Some of…”
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Synthesis of 3-(2'-furoyl)indole derivatives as potential new ligands at the benzodiazepine receptor, structurally more restrained analogues of indoleglyoxylylamides by Da Settimo, A, Primofiore, G, Da Settimo, F, Marini, A M, Novellino, E, Greco, G, Martini, C, Senatore, G, Lucacchini, A

“…A number of furoylindoles were synthesized with the aim of obtaining structurally more restrained analogues of the previously described indoleglyoxylylamides,…”
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2-(Benzimidazol-2-yl)quinoxalines : A novel class of selective antagonists at human A1 and as adenosine receptors designed by 3D database searching by NOVELLINO, Ettore, COSIMELLI, Barbara, DA SETTIMO, Federico, TALIANI, Sabrina, LA MOTTA, Concettina, KLOTZ, Karl-Norbert, TUSCANO, Daniela, TRINCAVELLI, Maria Letizia, MARTINI, Claudia, EHLARDO, Marina, GRECO, Giovanni, IADANZA, Manuela, LAVECCHIA, Antonio, RIMOLI, Maria Grazia, SALA, Annalisa, DA SETTIMO, Antonio, PRIMOFIORE, Giampaolo

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Indole derivatives as probes to study the benzodiazepine binding site in GABA receptor complex by Da Settimo, A, Primofiore, G, Da Settimo, F, Novellino, E, Greco, G, Martini, C, Senatore, G, Lucacehini, A

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Synthesis, Structure−Activity Relationships, and Molecular Modeling Studies of N-(Indol-3-ylglyoxylyl)benzylamine Derivatives Acting at the Benzodiazepine Receptor by Da Settimo, Antonio, Primofiore, Giampaolo, Da Settimo, Federico, Marini, Anna Maria, Novellino, Ettore, Greco, Giovanni, Martini, Claudia, Giannaccini, Gino, Lucacchini, Antonio

“…A number of N-(indol-3-ylglyoxylyl)benzylamine derivatives were synthesized and tested for [3H]flunitrazepam displacing activity in bovine brain membranes…”
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Recent advances in the development of dual topoisomerase I and II inhibitors as anticancer drugs by Salerno, S, Da Settimo, F, Taliani, S, Simorini, F, La Motta, C, Fornaciari, G, Marini, A M

“…DNA topoisomerases (topos) are essential enzymes that regulate the topological state of DNA during cellular processes such as replication, transcription,…”
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2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching by Novellino, Ettore, Cosimelli, Barbara, Ehlardo, Marina, Greco, Giovanni, Iadanza, Manuela, Lavecchia, Antonio, Rimoli, Maria Grazia, Sala, Annalisa, Da Settimo, Antonio, Primofiore, Giampaolo, Da Settimo, Federico, Taliani, Sabrina, La Motta, Concettina, Klotz, Karl-Norbert, Tuscano, Daniela, Trincavelli, Maria Letizia, Martini, Claudia

“…The Cambridge Structural Database (CSD) was searched through two 3D queries based on substructures shared by well-known antagonists at the A(1) and A(3)…”
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Synthesis and benzodiazepine receptor activity of some 4,5-dihydro-1H-pyrazolo[4,3-c][1,8]naphthyridine derivatives by Da Settimo, A, Primofiore, G, Da Settimo, F, Simorini, F, Barili, P L, Senatore, G, Martini, C, Lucacchini, A

“…The preparation of 5-substituted 1-aryl-4,5-dihydro-1H-pyrazolo[4,3- c][1,8] naphthyridines by reaction of 5-substituted…”
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Isosteric replacement of amide by ester function. Synthesis and benzodiazepine receptor affinity of indol-3-ylglyoxylyl ester derivatives by Da Settimo, A, Primofiore, G, Marini, A M, Da Settimo, F, Nuti, V, Martini, C, Trincavelli, L, Lucacchini, A

“…A number of benzyl and phenylethyl esters of indol-3-ylglyoxylic acid were synthesized and tested for their ability to displace [3H]Ro 15-1788 binding from…”
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Hydrogen sulphide: biopharmacological roles in the cardiovascular system and pharmaceutical perspectives by Martelli, A, Testai, L, Marino, A, Breschi, M C, Da Settimo, F, Calderone, V

“…Hydrogen sulphide (H(2)S) is now viewed as an important endogenous gasotransmitter, which exhibits many beneficial effects on the cardiovascular system. H(2)S…”
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Benzodiazepine receptor affinity and interaction of new indole derivatives by Da Settimo, A, Primofiore, G, Da Settimo, F, Lucacchini, A, Martini, C, Senatore, G

“…Recently, several derivatives, in which tryptamine, tyramine, and dopamine moieties are linked to the indole nucleus by an oxalyl bridge, were tested for their…”
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Synthesis of 2-methylaminobenzimidazole derivatives tested for antiinflammatory activity by Da Settimo, A, Marini, A M, Bianucci, A M, Primofiore, G, Da Settimo, F, Boldrini, E

“…A series of 1-alkyl substituted 2-methylaminobenzimidazole derivatives was prepared and tested. Some of them were assayed orally in the rat for…”
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Synthesis and antihypertensive activity of some 2-aminobenzimidazole and indole derivatives by Da Settimo, A, Marini, A M, Primofiore, G, Subissi, A

“…The synthesis of some 2-aminobenzimidazole and indole amide derivatives containing a 2,6-dichloroaniline moiety is described. The preparation of a theophylline…”
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