Search Results - "Da Rocha, André Monteiro"

Cardiac Kir2.1 and NaV1.5 Channels Traffic Together to the Sarcolemma to Control Excitability by Ponce-Balbuena, Daniela, Guerrero-Serna, Guadalupe, Valdivia, Carmen R, Caballero, Ricardo, Diez-Guerra, F Javier, Jiménez-Vázquez, Eric N, Ramírez, Rafael J, da Rocha, André Monteiro, Herron, Todd J, Campbell, Katherine F, Willis, B Cicero, Alvarado, Francisco J, Zarzoso, Manuel, Kaur, Kuljeet, Pérez-Hernández, Marta, Matamoros, Marcos, Valdivia, Héctor H, Delpón, Eva, Jalife, José

“…RATIONALE:In cardiomyocytes, NaV1.5 and Kir2.1 channels interact dynamically as part of membrane bound macromolecular complexes. OBJECTIVE:To test whether…”
Get full text

SNTA1 gene rescues ion channel function and is antiarrhythmic in cardiomyocytes derived from induced pluripotent stem cells from muscular dystrophy patients by Jimenez-Vazquez, Eric N, Arad, Michael, Macías, Álvaro, Vera-Pedrosa, Maria L, Cruz, Francisco Miguel, Gutierrez, Lilian K, Cuttitta, Ashley J, Monteiro da Rocha, André, Herron, Todd J, Ponce-Balbuena, Daniela, Guerrero-Serna, Guadalupe, Binah, Ofer, Michele, Daniel E, Jalife, José

“…Patients with cardiomyopathy of Duchenne Muscular Dystrophy (DMD) are at risk of developing life-threatening arrhythmias, but the mechanisms are unknown. We…”
Get full text

hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen by da Rocha, André Monteiro, Campbell, Katherine, Mironov, Sergey, Jiang, Jiang, Mundada, Lakshmi, Guerrero-Serna, Guadalupe, Jalife, José, Herron, Todd J.

“…Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) offer a novel in vitro platform for pre-clinical cardiotoxicity and pro-arrhythmia…”
Get full text

Abnormal myocardial expression of SAP97 is associated with arrhythmogenic risk by Musa, Hassan, Marcou, Cherisse A, Herron, Todd J, Makara, Michael A, Tester, David J, O'Connell, Ryan P, Rosinski, Brad, Guerrero-Serna, Guadalupe, Milstein, Michelle L, Monteiro da Rocha, André, Ye, Dan, Crotti, Lia, Nesterenko, Vladislav V, Castelletti, Silvia, Torchio, Margherita, Kotta, Maria-Christina, Dagradi, Federica, Antzelevitch, Charles, Mohler, Peter J, Schwartz, Peter J, Ackerman, Michael J, Anumonwo, Justus M

“…Synapse-associated protein 97 (SAP97) is a scaffolding protein crucial for the functional expression of several cardiac ion channels and therefore proper…”
Get more information

Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors by Zhang, Jianhua, Tao, Ran, Campbell, Katherine F., Carvalho, Juliana L., Ruiz, Edward C., Kim, Gina C., Schmuck, Eric G., Raval, Amish N., da Rocha, André Monteiro, Herron, Todd J., Jalife, José, Thomson, James A., Kamp, Timothy J.

“…Cardiac fibroblasts (CFs) play critical roles in heart development, homeostasis, and disease. The limited availability of human CFs from native heart impedes…”
Get full text

Loss of glycogen synthase kinase 3 isoforms during murine oocyte growth induces offspring cardiac dysfunction by Monteiro da Rocha, André, Ding, Jun, Slawny, Nicole, Wolf, Amber M, Smith, Gary D

“…Glycogen synthase kinase-3 (GSK3) is a constitutively active serine threonine kinase with 1) two isoforms (GSK3A and GSK3B) that have unique and overlapping…”
Get full text

Preventing erosion of X-chromosome inactivation in human embryonic stem cells by Cloutier, Marissa, Kumar, Surinder, Buttigieg, Emily, Keller, Laura, Lee, Brandon, Williams, Aaron, Mojica-Perez, Sandra, Erliandri, Indri, Rocha, Andre Monteiro Da, Cadigan, Kenneth, Smith, Gary D., Kalantry, Sundeep

“…X-chromosome inactivation is a paradigm of epigenetic transcriptional regulation. Female human embryonic stem cells (hESCs) often undergo erosion of…”
Get full text

Effect of Glucose on 3D Cardiac Microtissues Derived from Human Induced Pluripotent Stem Cells by Balistreri, Michael, Davis, Justin A., Campbell, Katherine F., Da Rocha, André Monteiro, Treadwell, Marjorie C., Herron, Todd J.

“…Maternal hyperglycemia is a risk factor for fetal cardiac anomalies. This study aimed to assess the effect of high glucose on human induced pluripotent stem…”
Get full text

A multiscale approach for bridging the gap between potency, efficacy, and safety of small molecules directed at membrane proteins by Aguayo-Ortiz, Rodrigo, Creech, Jeffery, Jiménez-Vázquez, Eric N., Guerrero-Serna, Guadalupe, Wang, Nulang, da Rocha, Andre Monteiro, Herron, Todd J., Espinoza-Fonseca, L. Michel

“…Membrane proteins constitute a substantial fraction of the human proteome, thus representing a vast source of therapeutic drug targets. Indeed, newly devised…”
Get full text

The relationship among HOXA10, estrogen receptor α, progesterone receptor, and progesterone receptor B proteins in rectosigmoid endometriosis: a tissue microarray study by Zanatta, Alysson, Pereira, Ricardo Mendes Alves, Rocha, André Monteiro da, Cogliati, Bruno, Baracat, Edmund Chada, Taylor, Hugh S, Motta, Eduardo Leme Alves da, Serafini, Paulo Cesar

“…Very few studies have evaluated the expression of homeobox A10 (HOXA10) and steroid (estrogen and progesterone) receptors exclusively in deep endometriosis…”
Get more information

Induced pluripotent stem cells from human placental chorion for perinatal tissue engineering applications by Jiang, Guihua, Di Bernardo, Julie, DeLong, Cynthia J, Monteiro da Rocha, André, O'Shea, K Sue, Kunisaki, Shaun M

“…The reliable derivation of induced pluripotent stem cells (iPSCs) from a noninvasive autologous source at birth would facilitate the study of patient-specific…”
Get more information

Extracellular Matrix–Mediated Maturation of Human Pluripotent Stem Cell–Derived Cardiac Monolayer Structure and Electrophysiological Function by Herron, Todd J, Rocha, Andre Monteiro Da, Campbell, Katherine F, Ponce-Balbuena, Daniela, Willis, B Cicero, Guerrero-Serna, Guadalupe, Liu, Qinghua, Klos, Matt, Musa, Hassan, Zarzoso, Manuel, Bizy, Alexandra, Furness, Jamie, Anumonwo, Justus, Mironov, Sergey, Jalife, José

“…BACKGROUND—Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) monolayers generated to date display an immature embryonic-like functional and…”
Get full text

Human perinatal stem cell derived extracellular matrix enables rapid maturation of hiPSC-CM structural and functional phenotypes by Block, Travis, Creech, Jeffery, da Rocha, Andre Monteiro, Marinkovic, Milos, Ponce-Balbuena, Daniela, Jiménez-Vázquez, Eric N., Griffey, Sy, Herron, Todd J.

“…The immature phenotype of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) is a major limitation to the use of these valuable cells for…”
Get full text

Paclitaxel mitigates structural alterations and cardiac conduction system defects in a mouse model of Hutchinson–Gilford progeria syndrome by Macías, Álvaro, Díaz-Larrosa, J Jaime, Blanco, Yaazan, Fanjul, Víctor, González-Gómez, Cristina, Gonzalo, Pilar, Andrés-Manzano, María Jesús, da Rocha, Andre Monteiro, Ponce-Balbuena, Daniela, Allan, Andrew, Filgueiras-Rama, David, Jalife, José, Andrés, Vicente

“…Abstract Aims Hutchinson–Gilford progeria syndrome (HGPS) is an ultrarare laminopathy caused by expression of progerin, a lamin A variant, also present at low…”
Get full text

Deficient cMyBP-C protein expression during cardiomyocyte differentiation underlies human hypertrophic cardiomyopathy cellular phenotypes in disease specific human ES cell derived cardiomyocytes by da Rocha, Andre Monteiro, DVM PhD, Guerrero-Serna, Guadalupe, PhD, Helms, Adam, MD, Luzod, Carly, Mironov, Sergey, PhD, Russell, Mark, MD, Jalife, José, MD, Day, Sharlene M., MD, Smith, Gary D., PhD, Herron, Todd J., PhD

“…Abstract Aims Mutations of cardiac sarcomere genes have been identified to cause HCM, but the molecular mechanisms that lead to cardiomyocyte hypertrophy and…”
Get full text

Targeted Reactivation of FMR1 Transcription in Fragile X Syndrome Embryonic Stem Cells by Haenfler, Jill M, Skariah, Geena, Rodriguez, Caitlin M, Monteiro da Rocha, Andre, Parent, Jack M, Smith, Gary D, Todd, Peter K

“…Fragile X Syndrome (FXS) is the most common inherited cause of intellectual disability and autism. It results from expansion of a CGG nucleotide repeat in the…”
Get full text

Exogenous DNA length and quantity affect the transfection rate, but not sperm viability during Sperm-Mediated Gene Transfer by Feitosa, Weber Beringui, Milazzotto, Marcella Pecora, Mendes, Camilla Mota, da Rocha, André Monteiro, Avanzo, José Luis, Martins, Elizabeth Angélica Leme, Visintin, José Antonio, Assumpção, Mayra Elena Ortiz D'Ávila

Get full text

In vitro model of ischemic heart failure using human induced pluripotent stem cell-derived cardiomyocytes by Davis, Justin, Chouman, Ahmad, Creech, Jeffery, Monteiro da Rocha, Andre, Ponce-Balbuena, Daniela, Jimenez Vazquez, Eric N, Nichols, Ruthann, Lozhkin, Andrey, Madamanchi, Nageswara R, Campbell, Katherine F, Herron, Todd J

“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been used extensively to model inherited heart diseases, but hiPSC-CM models of…”
Get full text

Bipolar Patient–Specific In Vitro Diagnostic Test Reveals Underlying Cardiac Arrhythmia Phenotype Caused by Calcium Channel Genetic Risk Factor by Dow, Rachel, DeLong, Cindy, Jiang, Guihua, Attili, Durga, Creech, Jeffery, Kraan, Rachel, Campbell, Katherine, Saraithong, Prakaimuk, O’Shea, Sue, Monteiro da Rocha, Andre, McInnis, Melvin G., Herron, Todd J.

“…A common genetic risk factor for bipolar disorder is CACNA1C, a gene that is also critical for cardiac rhythm. The impact of CACNA1C mutations on bipolar…”
Get full text

386 A novel truncating variant of EBF2 disrupts human adipocyte differentiation in lipodystrophy syndromes: an example of a discovery from a clinical translational pipeline by Foss-Freitas, Maria C., Wys, Noel, Udler, Miriam, Pais, Lynne, Rocha, Andre Monteiro da, MacDougald, Ormond A., Oral, Elif A., Chun, Tae-Hwa

“…OBJECTIVES/GOALS: Aiming to better understand the molecular pathogenesis of familial partial lipodystrophy (PL), we initiated whole-exome sequencing for our…”
Get full text