Search Results - "Da Fonte, Dillon F."

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination by Veit, Guido, Roldan, Ariel, Hancock, Mark A, Da Fonte, Dillon F, Xu, Haijin, Hussein, Maytham, Frenkiel, Saul, Matouk, Elias, Velkov, Tony, Lukacs, Gergely L

“…Based on its clinical benefits, Trikafta - the combination of folding correctors VX-661 (tezacaftor), VX-445 (elexacaftor), and the gating potentiator VX-770…”
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Readthrough-induced misincorporated amino acid ratios guide mutant-specific therapeutic approaches for two CFTR nonsense mutations by Premchandar, Aiswarya, Ming, Ruiji, Baiad, Abed, Da Fonte, Dillon F, Xu, Haijin, Faubert, Denis, Veit, Guido, Lukacs, Gergely L

“…Cystic fibrosis (CF) is a monogenic disease caused by mutations in the CF transmembrane conductance regulator ( ) gene. Premature termination codons (PTCs)…”
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Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons by Ehrlich, Aliza T, Semache, Meriem, Gross, Florence, Da Fonte, Dillon F, Runtz, Leonie, Colley, Christine, Mezni, Amina, Le Gouill, Christian, Lukasheva, Viktoriya, Hogue, Mireille, Darcq, Emmanuel, Bouvier, Michel, Kieffer, Brigitte L

“…G protein-coupled receptors are key signaling molecules and major targets for pharmaceuticals. The concept of ligand-dependent biased signaling raises the…”
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Secretoneurin A regulates neurogenic and inflammatory transcriptional networks in goldfish (Carassius auratus) radial glia by Da Fonte, Dillon F., Martyniuk, Christopher J., Xing, Lei, Pelin, Adrian, Corradi, Nicolas, Hu, Wei, Trudeau, Vance L.

“…Radial glial cells (RGCs) are the most abundant macroglia in the teleost brain and have established roles in neurogenesis and neurosteroidogenesis; however,…”
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Secretoneurin A Directly Regulates the Proteome of Goldfish Radial Glial Cells In Vitro by Da Fonte, Dillon F, Martyniuk, Chris J, Xing, Lei, Trudeau, Vance L

“…Radial glial cells (RGCs) are the main macroglia in the teleost brain and have established roles in neurogenesis and neurosteroidogenesis. They are the only…”
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Comparative analysis of goitrogenic effects of phenylthiourea and methimazole in zebrafish embryos by Fetter, Eva, Baldauf, Lisa, Da Fonte, Dillon F., Ortmann, Julia, Scholz, Stefan

“…•Goitrogen-induced teratogenicity, gene expression and behavior changes were studied.•Concentration-dependent effects could be shown for all endpoints…”
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Mutation-specific dual potentiators maximize rescue of CFTR gating mutants by Veit, Guido, Da Fonte, Dillon F., Avramescu, Radu G., Premchandar, Aiswarya, Bagdany, Miklos, Xu, Haijin, Bensinger, Dennis, Stubba, Daniel, Schmidt, Boris, Matouk, Elias, Lukacs, Gergely L.

“…•A subset of gating mutants are only partially potentiated by VX-770 (Ivacaftor).•These mutant activities are increased by rationally selected dual…”
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Peripheral chemoreceptors in fish: A brief history and a look ahead by Jonz, Michael G., Zachar, Peter C., Da Fonte, Dillon F., Mierzwa, Anna S.

“…The story of control of cardiorespiratory reflexes by peripheral chemoreceptors includes a chapter on evolution in large part because of the work of Prof…”
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Secretoneurin-A inhibits aromatase B ( cyp19a1b ) expression in female goldfish ( Carassius auratus ) radial glial cells by Da Fonte, Dillon F, Xing, Lei, Mikwar, Myy, Trudeau, Vance L

“…Highlights • Goldfish magnocellular secretoneurin A (SNa) neurons are surrounded by radial glial cells (RGCs). • In vivo and in vitro data indicate that SNa…”
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Mitochondria of teleost radial glia: A novel target of neuroendocrine disruption by environmental chemicals? by Souders, Christopher L., Wei, Chi, Schmidt, Jordan T., Da Fonte, Dillon F., Xing, Lei, Trudeau, Vance L., Martyniuk, Christopher J.

“…In teleost fish, radial glial cells (RGCs) are progenitor cells for neurons and the major cell type synthesizing neuroestrogens. We hypothesized that chemical…”
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Dehydroabietic acid cytotoxicity in goldfish radial glial cells in vitro by Xing, Lei, Gutierrez-Villagomez, Juan Manuel, Da Fonte, Dillon F., Venables, Maddie J., Trudeau, Vance L.

“…•DHAA is cytotoxic to goldfish radial glial cells in vitro at 20mg/L.•DHAA does not does not affect the enzyme activity levels of GST, GR and GPx at sub-lethal…”
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Proteomic profiling reveals dopaminergic regulation of progenitor cell functions of goldfish radial glial cells in vitro by Xing, Lei, Martyniuk, Christopher J., Esau, Crystal, Da Fonte, Dillon F., Trudeau, Vance L.

“…Radial glial cells (RGCs) are stem-like cells found in the developing and adult central nervous system. They function as both a scaffold to guide neuron…”
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Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells by Xing, Lei, McDonald, Heather, Da Fonte, Dillon F, Gutierrez-Villagomez, Juan M, Trudeau, Vance L

“…Radial glial cells (RGCs) are abundant stem-like non-neuronal progenitors that are important for adult neurogenesis and brain repair, yet little is known about…”
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Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cell by Lei eXing, Heather eMcDonald, Dillon F Da Fonte, Juan Manuel Gutierrez-Villagomez, Vance eTrudeau

“…Radial glial cells (RGCs) are abundant stem-like non-neuronal progenitors that are important for adult neurogenesis and brain repair, yet little is known about…”
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